References
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This is a list of films which have placed number one at the weekend box office in Ecuador during 2010.
| † | This implies the highest-grossing movie of the year. |
| # | Date | Film | Gross | Notes |
|---|---|---|---|---|
| 1 | January 3, 2010 | Avatar | $736,385 | |
| 2 | January 10, 2010 | $451,345 | ||
| 3 | January 17, 2010 | $508,987 | ||
| 4 | January 24, 2010 | Sherlock Holmes | $433,731 | |
| 5 | January 31, 2010 | Tooth Fairy | $398,819 | |
| 6 | February 7, 2010 | $426,616 | ||
| 7 | February 14, 2010 | Old Dogs | $439,357 | |
| 8 | February 21, 2010 | $436,406 | ||
| 9 | February 28, 2010 | $396,496 | ||
| 10 | March 7, 2010 | Alice in Wonderland | $704,221 | |
| 11 | March 14, 2010 | $569,062 | ||
| 12 | March 21, 2010 | $464,520 | ||
| 13 | March 28, 2010 | How to Train Your Dragon | $521,133 | |
| 14 | April 4, 2010 | $583,918 | ||
| 15 | April 11, 2010 | $417,340 | ||
| 16 | April 18, 2010 | $398,773 | ||
| 17 | April 25, 2010 | Clash of the Titans | $595,439 | |
| 18 | May 2, 2010 | Iron Man 2 | $736,811 | |
| 19 | May 9, 2010 | $498,791 | ||
| 20 | May 16, 2010 | $465,965 | ||
| 21 | May 23, 2010 | A Nightmare on Elm Street | $539,696 | |
| 22 | May 30, 2010 | Prince of Persia: The Sands of Time | $579,108 | |
| 23 | June 6, 2010 | $513,227 | ||
| 24 | June 13, 2010 | $420,131 | ||
| 25 | June 20, 2010 | Toy Story 3 † | $834,571 | |
| 26 | June 27, 2010 | $691,137 | ||
| 27 | July 4, 2010 | $595,762 | ||
| 28 | July 11, 2010 | Shrek Forever After | $751,941 | |
| 29 | July 18, 2010 | The Twilight Saga: Eclipse | $968,460 | |
| 30 | July 25, 2010 | Shrek Forever After | $804,864 | |
| 31 | August 1, 2010 | Despicable Me | $698,491 | |
| 32 | August 8, 2010 | $569,453 | ||
| 33 | August 15, 2010 | The Karate Kid | $595,764 | |
| 34 | August 22, 2010 | Cats & Dogs: The Revenge of Kitty Galore | $505,467 | |
| 35 | August 29, 2010 | The Karate Kid | $112,399 | |
| 36 | September 5, 2010 | Cats & Dogs: The Revenge of Kitty Galore | $409,378 | |
| 37 | September 12, 2010 | Resident Evil: Afterlife | $522,153 | |
| 38 | September 19, 2010 | $462,223 | ||
| 39 | September 26, 2010 | $388,923 | ||
| 40 | October 3, 2010 | $342,583 | ||
| 41 | October 10, 2010 | Piranha 3D | $342,608 | |
| 42 | October 17, 2010 | $281,176 | ||
| 43 | October 31, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $291,135 | |
| 44 | November 7, 2010 | A Turtle's Tale: Sammy's Adventures | $85,503 | |
| 45 | November 14, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $221,972 | |
| 46 | November 21, 2010 | Harry Potter and the Deathly Hallows – Part 1 | $671,374 | |
| 47 | December 5, 2010 | The Chronicles of Narnia: The Voyage of the Dawn Treader | $516,750 | |
| 48 | December 12, 2010 | $537,158 | ||
| 49 | December 19, 2010 | $405,851 | ||
| 50 | December 26, 2010 | Tron: Legacy | $591,938 | |
| 51 | January 2, 2011 | $590,510 |
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