| # | Weekend end date | Film | Weekend
gross | Top 10 openings |
|---|
| 1 | 2 January 2022 | Spider-Man: No Way Home | US$4,418,886 | Ghostbusters: Afterlife (#3), House of Gucci (#5) |
| 2 | 9 January 2022 | US$2,882,883 | The King's Man (#4), The Addams Family 2 (#6) |
| 3 | 16 January 2022 | US$1,955,229 | King Richard (#6), The 355 (#9) |
| 4 | 23 January 2022 | US$1,545,545 | Nightmare Alley (#6), Spencer (#8) |
| 5 | 30 January 2022 | US$1,162,815 | |
| 6 | 6 February 2022 | Jackass Forever | US$1,753,244 | Moonfall (#3), Belfast (#4) |
| 7 | 13 February 2022 | Death on the Nile | US$1,177,585 | Marry Me (#2), Blacklight (#5) |
| 8 | 20 February 2022 | Uncharted | US$4,038,904 | |
| 9 | 27 February 2022 | US$3,032,561 | Gangubai Kathiawadi (#7), Bheemla Nayak (#9), Studio 666 (#10) |
| 10 | 6 March 2022 | The Batman | US$8,504,634 | Monster Family 2 (#5) |
| 11 | 13 March 2022 | US$5,284,095 | Radhe Shyam (#3), Off the Rails (#7) |
| 12 | 20 March 2022 | US$3,075,543 | Dog (#2), Jujutsu Kaisen 0 (#3), Bachchhan Paandey (#9) |
| 13 | 27 March 2022 | US$2,153,480 | RRR (#2), X (#6) |
| 14 | 3 April 2022 | Sonic the Hedgehog 2 | US$2,800,000 | Morbius (#2), The Bad Guys (#3), The Duke (#5) |
| 15 | 10 April 2022 | Fantastic Beasts: The Secrets of Dumbledore | US$3,906,720 | Ambulance (#5), Rabbit Academy (#9), Galwakdi (#10) |
| 16 | 17 April 2022 | US$2,409,968 | K.G.F: Chapter 2 (#3), Everything Everywhere All at Once (#4), Beast (#7) |
| 17 | 24 April 2022 | US$1,649,625 | The Northman (#3), The Unbearable Weight of Massive Talent (#4) |
| 18 | 1 May 2022 | Downton Abbey: A New Era | US$1,339,894 | Acharya (#7), Kaathuvaakula Rendu Kaadhal (#10) |
| 19 | 8 May 2022 | Doctor Strange in the Multiverse of Madness | US$10,278,105 | The Drover's Wife (#7), Maa (#8) |
| 20 | 15 May 2022 | US$5,090,050 | Operation Mincemeat (#3), Sarkaru Vaari Paata (#8), Firestarter (#10) |
| 21 | 22 May 2022 | US$2,729,177 | How to Please a Woman (#3), Last Seen Alive (#4), Bhool Bhulaiyaa 2 (#8) |
| 22 | 29 May 2022 | Top Gun: Maverick | US$12,992,111 | The Bob's Burgers Movie (#3), F3 (#8) |
| 23 | 5 June 2022 | US$9,300,000 | Vikram (#3), Major (#10) |
| 24 | 12 June 2022 | Jurassic World Dominion | US$8,540,281 | Ante Sundaraniki (#8) |
| 25 | 19 June 2022 | US$4,811,357 | Lightyear (#3) |
| 26 | 26 June 2022 | Elvis | US$4,678,888 | Minions: The Rise of Gru (#2), Jugjugg Jeeyo (#6), Freedom Uncut (#9), Sher Bagga (#10) |
| 27 | 3 July 2022 | Minions: The Rise of Gru | US$5,567,454 | The Roundup (#6), Rocketry: The Nambi Effect (#9) |
| 28 | 10 July 2022 | Thor: Love and Thunder | US$10,807,108 | Shareek 2 (#7) |
| 29 | 17 July 2022 | US$4,860,515 | Falling for Figaro (#7), The Phantom of the Open (#8), Bajre Da Sitta (#9), Kaduva (#10) |
| 30 | 24 July 2022 | US$2,457,360 | Where the Crawdads Sing (#2), The Black Phone (#5), Shamshera (#8) |
| 31 | 31 July 2022 | US$1,498,151 | Chhalla Mud Ke Nahi Aya (#7), Lee Kernaghan Boy From The Bush (#9) |
| 32 | 7 August 2022 | Bullet Train | US$2,182,191 | Sita Ramam (#9) |
| 33 | 14 August 2022 | US$1,293,891 | Nope (#2), Laal Singh Chaddha (#5) |
| 34 | 21 August 2022 | US$899,665 | Dragon Ball Super: Super Hero (#3), Good Luck to You, Leo Grande (#5) |
| 35 | 28 August 2022 | Nope | US$351,687 | Beast (#2) |
| 36 | 4 September 2022 | Bullet Train | US$601,739 | Orphan: First Kill (#2), Three Thousand Years of Longing (#3) |
| 37 | 11 September 2022 | Brahmastra Part 1: Shiva | US$618,267 | After Ever Happy (#2) |
| 38 | 18 September 2022 | Ticket to Paradise | US$2,041,598 | DC League of Super-Pets (#2), Moonage Daydream (#3), Bodies Bodies Bodies (#8) |
| 39 | 25 September 2022 | US$1,875,801 | Fall (#4), Paws of Fury: The Legend of Hank (#5) |
| 40 | 2 October 2022 | DC League of Super-Pets | US$1,782,265 | Smile (#3), Ponniyin Selvan: I (#4), See How They Run (#5), Vikram Vedha (#9) |
| 41 | 9 October 2022 | Don't Worry Darling | US$1,359,226 | Amsterdam (#4), Wog Boys Forever (#5), Babe Bhangra Paunde Ne (#9) |
| 42 | 16 October 2022 | Halloween Ends | US$905,431 | The Legend of Maula Jatt (#7) |
| 43 | 23 October 2022 | Black Adam | US$4,764,010 | Barbarian (#6) |
| 44 | 30 October 2022 | US$2,272,984 | Mrs. Harris Goes to Paris (#2), The Woman King (#3), Bros (#5), Terrifier 2 (#7), Coldplay: Music of the Spheres: Live Broadcast from Buenos Aires (#10) |
| 45 | 6 November 2022 | US$1,451,583 | One Piece Film: Red (#3) |
| 46 | 13 November 2022 | Black Panther: Wakanda Forever | US$6,277,374 | |
| 47 | 20 November 2022 | US$3,718,677 | She Said (#4), Drishyam 2 (#5), On The Line (#6) |
| 48 | 27 November 2022 | US$1,896,627 | The Menu (#2), Strange World (#3), Bones and All (#7), Seriously Red (#8), Bhediya (#10) |
| 49 | 4 December 2022 | US$1,241,304 | Violent Night (#3), HIT: The Second Case (#8) |
| 50 | 11 December 2022 | US$880,604 | Tad, the Lost Explorer and the Emerald Tablet (#9) |
| 51 | 18 December 2022 | Avatar: The Way of Water | US$9,855,736 | |
| 52 | 25 December 2022 | US$4,812,746 | Cirkus (#5), Dhamaka (#10) |
