This is a list of films which placed number-one at the weekend box office in Brazil during 2021. [1]
| † | This implies the highest-grossing movie of the year. [2] |
| # | Weekend end date | Film | Box office |
|---|---|---|---|
| 1 | January 3, 2021 | Wonder Woman 1984 | US$400,501 |
| 2 | January 10, 2021 | US$610,645 | |
| 3 | January 17, 2021 | US$375,528 | |
| 4 | January 24, 2021 | US$250,434 | |
| 5 | January 31, 2021 | US$141,025 [3] | |
| 6 | February 7, 2021 | US$174,048 [4] | |
| 7 | February 14, 2021 | Tom & Jerry | US$204,460 [5] |
| 8 | February 21, 2021 | US$746,000 | |
| 9 | February 28, 2021 | US$199,275 [6] | |
| 10 | March 7, 2021 | Raya and the Last Dragon | US$45,068 |
| 11 | March 14, 2021 | US$23,171 | |
| 12 | March 21, 2021 | US$7,322 | |
| 13 | March 28, 2021 | US$1,128 | |
| 14 | April 4, 2021 | US$5,074 | |
| 15 | April 11, 2021 | US$7,109 | |
| 16 | April 18, 2021 | US$5,786 | |
| 17 | April 25, 2021 | US$10,625 | |
| 18 | May 2, 2021 | Godzilla vs. Kong | US$479,629 [7] |
| 19 | May 9, 2021 | US$363,984 [8] | |
| 20 | May 16, 2021 | US$325,000 | |
| 21 | May 23, 2021 | Mortal Kombat | US$264,150 [9] |
| 22 | May 30, 2021 | Cruella | US$324,589 |
| 23 | June 6, 2021 | US$384,915 | |
| 24 | June 13, 2021 | The Conjuring: The Devil Made Me Do It | US$1,300,000 |
| 25 | June 20, 2021 | Spiral | US$276,672 |
| 26 | June 27, 2021 | F9 | US$2,651,000 |
| 27 | July 4, 2021 | The Croods: A New Age | US$500,000 |
| 28 | July 11, 2021 | Black Widow | US$2,406,060 |
| 29 | July 18, 2021 | US$1,383,639 | |
| 30 | July 25, 2021 | A Quiet Place Part II | US$845,000 |
| 31 | August 1, 2021 | F9 | US$505,305 [10] |
| 32 | August 8, 2021 | The Suicide Squad | US$1,805,249 |
| 32 | August 15, 2021 | US$1,952,857 | |
| 33 | August 22, 2021 | Free Guy | US$1,031,712 |
| 34 | August 29, 2021 | US$847,697 | |
| 35 | September 5, 2021 | Shang-Chi and the Legend of the Ten Rings | US$2,087,843 |
| 36 | September 12, 2021 | US$3,388,993 | |
| 37 | September 19, 2021 | US$854,094 | |
| 38 | September 26, 2021 | US$769,457 | |
| 39 | October 3, 2021 | No Time to Die | US$1,302,000 |
| 40 | October 10, 2021 | Venom: Let There Be Carnage | US$2,821,472 |
| 41 | October 17, 2021 | US$2,397,322 | |
| 42 | October 24, 2021 | US$1,136,937 [11] | |
| 43 | October 31, 2021 | US$757,958 [12] | |
| 44 | November 7, 2021 | Eternals | US$4,168,216 |
| 45 | November 14, 2021 | US$2,402,175 | |
| 46 | November 21, 2021 | US$1,101,210 | |
| 47 | November 28, 2021 | Encanto | US$732,636 |
| 48 | December 5, 2021 | US$694,344 | |
| 49 | December 12, 2021 | US$554,833 | |
| 50 | December 19, 2021 | Spider-Man: No Way Home † | US$17,900,000 [13] |
| 51 | December 26, 2021 | US$5,000,000 [14] |
| Rank | Title | Distributor | Domestic gross | Ref. |
|---|---|---|---|---|
| 1 | Spider-Man: No Way Home | Sony | $31,700,000 | [15] |
| 2 | F9 | Universal | $13,956,552 | — |
| 3 | Eternals | Disney | $12,803,264 | |
| 4 | Venom: Let There Be Carnage | Sony | $12,100,000 | |
| 5 | Shang-Chi and the Legend of the Ten Rings | Disney | $7,487,715 | |
| 6 | Black Widow | $6,620,265 | ||
| 7 | The Conjuring: The Devil Made Me Do It | Warner Bros. | $6,000,000 | |
| 8 | The Suicide Squad | $4,500,000 | ||
| 9 | No Time to Die | Universal | $3,900,000 | [16] |
| 10 | Wonder Woman 1984 | Warner Bros. | $3,574,690 | — |
| 11 | Encanto | Disney | $3,390,586 | |
| 12 | Space Jam: A New Legacy | Warner Bros. | $2,800,000 | |
| 13 | Dune | $2,720,000 | [16] | |
| 14 | PAW Patrol: The Movie | Paramount | $2,385,720 | [17] |
| 15 | The Croods: A New Age | Universal | $2,320,000 | — |
| 16 | Cruella | Disney | $2,115,182 | |
| 17 | A Quiet Place Part II | Paramount | $2,068,585 | [17] |
| 18 | Free Guy | Disney | $1,556,192 | — |
| 19 | The Boss Baby: Family Business | Universal | $1,456,000 | |
| 20 | Godzilla vs. Kong | Warner Bros. | $1,308,603 | [17] |
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