| # | Week ending | Film | Notes | Ref |
|---|
| 1 | January 3, 1968 | Valley of the Dolls | | [2] |
| 2 | January 10, 1968 | | [3] |
| 3 | January 17, 1968 | | [4] |
| 4 | January 24, 1968 | Valley of the Dolls grossed more than $500,000 from 24 key cities | [5] |
| 5 | January 31, 1968 | | [2] |
| 6 | February 7, 1968 | | [6] |
| 7 | February 14, 1968 | Guess Who's Coming to Dinner | Guess Who's Coming to Dinner grossed $603,000 from 12 cities | [7] |
| 8 | February 21, 1968 | Guess Who's Coming to Dinner grossed nearly $600,000 from 13 cities | [8] |
| 9 | February 28, 1968 | Guess Who's Coming to Dinner grossed nearly $900,000 from 18 cities | [9] |
| 10 | March 6, 1968 | Guess Who's Coming to Dinner grossed $718,500 from 17 cities | [10] |
| 11 | March 13, 1968 | The Graduate | | [11] |
| 12 | March 20, 1968 | | [12] |
| 13 | March 27, 1968 | | [13] |
| 14 | April 3, 1968 | | [14] |
| 15 | April 10, 1968 | | [15] |
| 16 | April 17, 1968 | | [16] |
| 17 | April 24, 1968 | | [17] |
| 18 | May 1, 1968 | | [18] |
| 19 | May 8, 1968 | | [19] |
| 20 | May 15, 1968 | | [20] |
| 21 | May 22, 1968 | | [21] |
| 22 | May 29, 1968 | | [22] |
| 23 | June 5, 1968 | | [23] |
| 24 | June 12, 1968 | | [24] |
| 25 | June 19, 1968 | 2001: A Space Odyssey | 2001: A Space Odyssey reached number one in its eleventh week of release | [25] |
| 26 | June 26, 1968 | The Odd Couple | The Odd Couple grossed $509,000 from 11 key cities | [26] |
| 27 | July 3, 1968 | | [27] |
| 28 | July 10, 1968 | The Odd Couple grossed $711,000 in the cities sampled | [28] |
| 29 | July 17, 1968 | | [29] |
| 30 | July 24, 1968 | | [30] |
| 31 | July 31, 1968 | The Odd Couple grossed $545,000 in the cities sampled | [31] |
| 32 | August 7, 1968 | | [32] |
| 33 | August 14, 1968 | Rosemary's Baby | | [33] |
| 34 | August 21, 1968 | | [34] |
| 35 | August 28, 1968 | | [35] |
| 36 | September 4, 1968 | | [36] |
| 37 | September 11, 1968 | 2001: A Space Odyssey | 2001: A Space Odyssey returned to number one in its 23rd week of release | [37] |
| 38 | September 18, 1968 | Rosemary's Baby | | [38] |
| 39 | September 25, 1968 | Rachel, Rachel | Rachel, Rachel grossed more than $300,000 in the cities sampled | [39] |
| 40 | October 2, 1968 | | [40] |
| 41 | October 9, 1968 | | [41] |
| 42 | October 16, 1968 | Barbarella | | [42] |
| 43 | October 23, 1968 | | [43] |
| 44 | October 30, 1968 | Funny Girl † | Funny Girl reached number one in its sixth week of release | [44] |
| 45 | November 6, 1968 | | [45] |
| 46 | November 13, 1968 | | [46] |
| 47 | November 20, 1968 | | [47] |
| 48 | November 27, 1968 | | [48] |
| 49 | December 4, 1968 | | [49] |
| 50 | December 11, 1968 | | [50] |
| 51 | December 18, 1968 | | [51] |
| 52 | December 25, 1968 | Candy | | [52] |
|