| # | Date | Film | Gross | Notes |
|---|
| 1 | January 3, 2016 | Hotel Transylvania 2 | $196,960 | Hotel Transylvania 2 reclaimed the #1 spot in its fifteenth weekend of release. |
| 2 | January 10, 2016 | Star Wars: The Force Awakens | $1,227,978 | Star Wars: The Force Awakens reclaimed the #1 spot in its fourth weekend of release. |
| 3 | January 17, 2016 | Point Break | $2,146,886 | Point Break had the highest weekend debut of 2016 before the inflation. |
| 4 | January 24, 2016 | $1,673,720 | |
| 5 | January 31, 2016 | The 5th Wave | $70,238 | Starting from this week Venezuela's Box Office suffered an inflation of over 3 points, for so, the box office numbers are lower than the past. [1] |
| 6 | February 7, 2016 | Point Break | $33,126 | |
| 7 | February 14, 2016 | Daddy's Home | $50,410 | Daddy's Home reached the #1 spot in its second weekend of release. |
| 8 | February 21, 2016 | Zootopia | $142,591 | |
| 9 | February 28, 2016 | $174,500 | |
| 10 | March 6, 2016 | $172,482 | |
| 11 | March 13, 2016 | $50,656 | |
| 12 | March 20, 2016 | Kung Fu Panda 3 | $71,722 | |
| 13 | March 27, 2016 | Batman v Superman: Dawn of Justice | $125,468 | |
| 14 | April 3, 2016 | $178,742 | |
| 15 | April 10, 2016 | $210,146 | |
| 16 | April 17, 2016 | The Jungle Book | $153,714 | |
| 17 | April 24, 2016 | $100,483 | |
| 18 | May 1, 2016 | $82,146 | |
| 19 | May 8, 2016 | Captain America: Civil War | $578,489 | |
| 20 | May 15, 2016 | $394,782 | |
| 21 | May 22, 2016 | The Angry Birds Movie | $372,485 | |
| 22 | May 29, 2016 | X-Men: Apocalypse | $419,165 | |
| 23 | June 5, 2016 | Teenage Mutant Ninja Turtles: Out of the Shadows | $516,822 | |
| 24 | June 12, 2016 | The Conjuring 2 | $116,852 | |
| 25 | June 19, 2016 | Finding Dory | $240,500 | |
| 26 | June 26, 2016 | $376,505 | |
| 27 | July 3, 2016 | $324,539 | |
| 28 | July 10, 2016 | $225,000 | |
| 29 | July 17, 2016 | $180,000 | |
| 30 | July 24, 2016 | $130,976 | |
| 31 | July 31, 2016 | $70,000 | |
| 32 | August 7, 2016 | The Secret Life of Pets | $148,000 | |
| 33 | August 14, 2016 | Pete's Dragon | $118,652 | |
| 34 | August 21, 2016 | Ben-Hur | $1,127,927 | |
| 35 | August 28, 2016 | $332,854 | |
| 36 | September 4, 2016 | Star Trek Beyond | $1,669,317 | |
| 37 | September 11, 2016 | $831,172 | |
| 38 | September 18, 2016 | $351,266 | |
| 39 | September 25, 2016 | The BFG | $89,988 | |
| 40 | October 2, 2016 | Deepwater Horizon | $73,728 | |
| 41 | October 9, 2016 | $51,369 | |
| 42 | October 16, 2016 | Inferno | $53,366 | |
| 43 | October 23, 2016 | $37,590 | |
| 44 | October 30, 2016 | $28,967 | |
| 45 | November 6, 2016 | Doctor Strange | $276,000 | |
| 46 | November 13, 2016 | $202,100 | |
| 47 | November 20, 2016 | $159,750 | |
| 48 | November 27, 2016 | Jack Reacher: Never Go Back | $1,878,293 | |
| 49 | December 4, 2016 | $940,685 | |
| 50 | December 11, 2016 | Office Christmas Party | $3,594,391 | Office Christmas Party had the highest weekend debut of 2016 after the ongoing inflation. |
| 51 | December 18, 2016 | $2,769,190 | |
| 52 | December 25, 2016 | Rogue One: A Star Wars Story | $99,495 | Rogue One: A Star Wars Story reached the #1 spot in its second weekend of release. |
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