| Week | Weekend End Date | Film | Total weekend gross (Pound sterling) | Weekend openings in the Top 10 | Reference(s) |
|---|
| 1 | 3 January 2010 | Avatar [a] † | £5,940,479 | Did You Hear About the Morgans? (#4) | [2] |
| 2 | 10 January 2010 | £4,770,980 | Daybreakers (#3), It's Complicated (#5), The Road (#6), Sex & Drugs & Rock & Roll (#10) | [3] |
| 3 | 17 January 2010 | £5,527,039 | Up in the Air (#5), The Book of Eli (#6) | [4] |
| 4 | 24 January 2010 | £5,155,844 | Toy Story 2 3D (#6), Brothers (#9), A Prophet (#10) | [5] |
| 5 | 31 January 2010 | £4,865,081 | Edge of Darkness (#3), Precious: Based on the Novel 'Push' by Sapphire (#9) | [6] |
| 6 | 7 February 2010 | £4,338,774 | The Princess and the Frog (#2), Astro Boy (#3), Invictus (#4), Youth in Revolt (#7) | [7] |
| 7 | 14 February 2010 | Valentine's Day | £3,732,393 | The Wolfman (#3), Percy Jackson & the Olympians: The Lightning Thief (#5), My Name is Khan (#6), A Single Man (#8) | [8] |
| 8 | 21 February 2010 | Avatar † | £2,817,009 | The Lovely Bones (#3), Solomon Kane (#7) | [9] |
| 9 | 28 February 2010 | £2,260,319 | The Crazies (#3), Leap Year (#7), From Paris with Love (#8) | [10] |
| 10 | 7 March 2010 | Alice in Wonderland | £10,555,220 | | [11] |
| 11 | 14 March 2010 | £7,343,506 | Shutter Island (#2), Green Zone (#3), Hachi: A Dog's Tale (#5), The Girl with the Dragon Tattoo (#6) | [12] |
| 12 | 21 March 2010 | £4,847,129 | The Bounty Hunter (#2), I Love You Phillip Morris (#4), The Spy Next Door (#6) | [13] |
| 13 | 28 March 2010 | Nanny McPhee and the Big Bang | £2,586,760 | The Blind Side (#3), Shank (#9) | [14] |
| 14 | 4 April 2010 | Clash of the Titans | £5,682,875 | How to Train Your Dragon (#2), Kick-Ass (#3), Remember Me (#7) | [15] |
| 15 | 11 April 2010 | £2,441,682 | Whip It (#8) | [16] |
| 16 | 18 April 2010 | Dear John | £1,995,301 | The Ghost Writer (#6), Cemetery Junction (#7) | [17] |
| 17 | 25 April 2010 | Date Night | £1,272,405 | It's a Wonderful Afterlife (#7), The Joneses (#10) | [18] |
| 18 | 2 May 2010 | Iron Man 2 | £7,664,732 | The Last Song (#4), House Full (#10) | [19] |
| 19 | 9 May 2010 | £3,214,776 | Furry Vengeance (#2), A Nightmare on Elm Street (#3), Hot Tub Time Machine (#4), The Back-up Plan (#5), Four Lions (#6) | [20] |
| 20 | 16 May 2010 | Robin Hood | £5,750,332 | | [21] |
| 21 | 23 May 2010 | StreetDance 3D | £2,493,948 | Prince of Persia: The Sands of Time (#2), Kites (#5), Bad Lieutenant: Port of Call New Orleans (#9) | [22] |
| 22 | 30 May 2010 | Sex and the City 2 | £6,142,718 | Tooth Fairy (#5), Space Chimps 2: Zartog Strikes Back (#7), The Losers (#8) | [23] |
| 23 | 6 June 2010 | £2,473,043 | Death at a Funeral (#4), 4.3.2.1 (#7), She's Out of My League (#8) | [24] |
| 24 | 13 June 2010 | £1,489,833 | Letters to Juliet (#2), Brooklyn's Finest (#5) | [25] |
| 25 | 20 June 2010 | Killers | £1,053,074 | Wild Target (#7) | [26] |
| 26 | 27 June 2010 | Get Him to the Greek | £1,569,556 | The Collector (#7) | [27] |
| 27 | 4 July 2010 | Shrek Forever After | £8,955,554 | I Hate Luv Storys (#5), Heartbreaker (#6) | [28] |
| 28 | 11 July 2010 | The Twilight Saga: Eclipse | £13,756,653 | Predators (#3), Milenge Milenge (#10) | [29] |
| 29 | 18 July 2010 | Inception | £5,912,814 | Leaving (#9), The Concert (#10) | [30] |
| 30 | 25 July 2010 | Toy Story 3 | £21,187,264 | The Rebound (#5), Khatta Meetha (#7), Splice (#9), | [31] |
| 31 | 1 August 2010 | £8,115,193 | The Karate Kid (#2), The A-Team (#3), Gainsbourg (#8), Once Upon a Time in Mumbaai (#8) | [32] |
| 32 | 8 August 2010 | £4,666,021 | Knight and Day (#2), Step Up 3D (#4), Cats & Dogs: The Revenge of Kitty Galore (#5) | [33] |
| 33 | 15 August 2010 | £3,162,944 | The Last Airbender (#3), The Sorcerer's Apprentice (#5), Tinker Bell and the Great Fairy Rescue (#10) | [34] |
| 34 | 22 August 2010 | The Expendables | £3,910,596 | Salt (#2), Piranha 3D (#4), Marmaduke (#5) | [35] |
| 35 | 29 August 2010 | Grown Ups | £2,006,945 | Scott Pilgrim vs. the World (#2), Diary of a Wimpy Kid (#8) | [36] |
| 36 | 5 September 2010 | The Last Exorcism | £1,104,856 | Dinner for Schmucks (#2), The Switch (#6) | [37] |
| 37 | 12 September 2010 | Resident Evil: Afterlife | £1,690,655 | Tamara Drewe (#5), Going the Distance (#7), Cyrus (#8) | [38] |
| 38 | 19 September 2010 | The Other Guys | £1,980,601 | Devil (#2) | [39] |
| 39 | 26 September 2010 | £1,292,144 | Eat Pray Love (#2), The Town (#3), The Hole (#4) | [40] |
| 40 | 3 October 2010 | £976,459 | Buried (#3), Made in Dagenham (#6), Back to the Future (#7) | [41] |
| 41 | 10 October 2010 | Wall Street: Money Never Sleeps | £1,784,309 | Life as We Know It (#2), The Death and Life of Charlie St. Cloud (#3) | [42] |
| 42 | 17 October 2010 | Despicable Me | £3,664,376 | The Social Network (#2), Vampires Suck (#3) | [43] |
| 43 | 24 October 2010 | Paranormal Activity 2 | £3,764,722 | Red (#3), Legend of the Guardians: The Owls of Ga'Hoole (#5), Alpha and Omega (#5), Easy A (#8) | [44] |
| 44 | 31 October 2010 | Saw 3D | £3,600,083 | Burke & Hare (#6), The Kids Are All Right (#9) | [45] |
| 45 | 7 November 2010 | Due Date | £2,346,089 | Jackass 3D (#2), Let Me In (#8), Another Year (#9) | [46] |
| 46 | 14 November 2010 | £1,898,324 | Skyline (#2) | [47] |
| 47 | 21 November 2010 | Harry Potter and the Deathly Hallows – Part 1 | £18,319,721 | Guzaarish (#8) | [48] |
| 48 | 28 November 2010 | £8,344,776 | Unstoppable (#2), London Boulevard (#3), The American (#5), The Girl Who Kicked the Hornet's Nest (#7), Machete (#10) | [49] |
| 49 | 5 December 2010 | £3,739,781 | Megamind (#2), Monsters (#5), The Warrior's Way (#10) | [50] |
| 50 | 12 December 2010 | The Chronicles of Narnia: The Voyage of the Dawn Treader | £2,460,118 | The Tourist (#3), Somewhere (#8), No Problem (#9) | [51] |
| 51 | 19 December 2010 | Tron: Legacy | £1,970,692 | Burlesque (#6), Animals United (#7), Fred: The Movie (#8) | [52] |
| 52 | 26 December 2010 | Little Fockers | £3,035,717 | Tees Maar Khan (#5), Arthur and the Great Adventure (#9) | [53] |