| # | Date | Film | Gross (USD) | Openings in the top ten |
|---|
| 1 | January 4, 2009 | Bedtime Stories | $2,421,651 | |
| 2 | January 11, 2009 | $1,421,902 | Seven Pounds (#2), The Flock (#9) |
| 3 | January 18, 2009 | The Curious Case of Benjamin Button | $1,410,087 | Marley & Me (#3), The Argentine (#8) |
| 4 | January 25, 2009 | $1,347,802 | Hotel for Dogs (#2), My Best Friend's Girl (#6), The Spirit (#9) |
| 5 | February 1, 2009 | Yes Man | $1,345,462 | Inkheart (#2), Bride Wars (#3), Revolutionary Road (#8), Quarantine (#10) |
| 6 | February 8, 2009 | Coraline | $1,198,984 | Underworld: Rise of the Lycans (#3), Righteous Kill (#8), Big Stan (#9) |
| 7 | February 15, 2009 | Valkyrie | $1,440,752 | My Bloody Valentine 3D (#3), El Agente 00-P2 (#6), Confessions of a Shopaholic (#7) |
| 8 | February 22, 2009 | $836,296 | Slumdog Millionaire (#3), El Traspatio (#5), Doubt (#10) |
| 9 | March 1, 2009 | Slumdog Millionaire | $783,030 | The Pink Panther 2 (#2), Changeling (#5), Amar (#7) |
| 10 | March 8, 2009 | Watchmen | $717,056 | Jonas Brothers: The 3D Concert Experience (#4), He's Just Not That Into You (#5) |
| 11 | March 15, 2009 | The Unborn | $1,292,182 | Paul Blart: Mall Cop (#2) |
| 12 | March 22, 2009 | Otra Película de Huevos y un Pollo | $2,225,866 | The International (#5), Last Chance Harvey (#10) |
| 13 | March 29, 2009 | $1,404,352 | Knowing (#2), Race to Witch Mountain (#3), Gran Torino (#6) |
| 14 | April 5, 2009 | Fast & Furious | $3,543,145 | Monsters vs. Aliens (#2), The Accidental Husband (#6), The Reader (#8) |
| 15 | April 12, 2009 | $1,942,723 | Dragonball Evolution (#3), Amar a Morir (#4), Duplicity (#5) |
| 16 | April 19, 2009 | $1,094,532 | The Haunting in Connecticut (#3), El Libro de Piedra (#10) |
| 17 | April 26, 2009 | $435,849 | Igor (#7), I Love You, Man (#10) |
| 18 | May 3, 2009 | Theatres closed due to the Swine flu outbreak in Mexico |
| 19 | May 10, 2009 | The Haunting in Connecticut | $204,065 | |
| 20 | May 17, 2009 | Ghosts of Girlfriends Past | $912,056 | Earth (#4), Push (#5), Sin Nombre (#7) |
| 21 | May 24, 2009 | Angels & Demons | $4,186,265 | Hannah Montana: The Movie (#2), The Last House on the Left (#8) |
| 22 | May 31, 2009 | X-Men Origins: Wolverine | $3,971,362 | |
| 23 | June 7, 2009 | Up | $3,601,639 | Star Trek (#4), State of Play (#5) |
| 24 | June 14, 2009 | Night at the Museum: Battle of the Smithsonian | $3,243,766 | While She Was Out (#9) |
| 25 | June 21, 2009 | $1,875,307 | The Proposal (#3), 17 Again (#4) |
| 26 | June 28, 2009 | Transformers: Revenge of the Fallen | $5,110,423 | My Sister's Keeper (#7) |
| 27 | July 5, 2009 | Ice Age 3 | $9,162,498 | Public Enemies (#3) |
| 28 | July 12, 2009 | $6,255,397 | All Inclusive (#5), Thick as Thieves (#6) |
| 29 | July 19, 2009 | Harry Potter and the Half-Blood Prince | $6,660,905 | It's Alive (#9) |
| 30 | July 26, 2009 | $2,653,327 | The Uninvited (#3), Crossing Over (#6) |
| 31 | August 2, 2009 | Terminator Salvation | $2,652,265 | G-Force (#2) |
| 32 | August 9, 2009 | G.I. Joe: The Rise of Cobra | $2,247,899 | Shorts (#6), Enemigos Intimos (#9) |
| 33 | August 16, 2009 | The Hangover | $1,379,008 | Land of the Lost (#4), El Ratón Pérez 2 (#10) |
| 34 | August 23, 2009 | $1,020,467 | Drag Me to Hell (#2), The Time Traveler's Wife (#5), Imagine That (#7), Sólo Quiero Caminar (#8) |
| 35 | August 30, 2009 | $1,006,200 | Aliens in the Attic (#2), A Propósito de Alexa (#4), Defiance (#8) |
| 36 | September 6, 2009 | The Ugly Truth | $903,379 | Orphan (#2), Tinker Bell and the Lost Treasure (#3) |
| 37 | September 13, 2009 | $696,355 | Dance Flick (#7), New in Town (#8) |
| 38 | September 20, 2009 | Cloudy with a Chance of Meatballs | $1,493,922 | |
| 39 | September 27, 2009 | $1,220,525 | The Taking of Pelham (#2), Whiteout (#4), Spread (#7) |
| 40 | October 4, 2009 | Surrogates | $864,247 | Jennifer's Body (#4), La Véritable Histoire du Chat Botte (#5) |
| 41 | October 11, 2009 | Inglourious Basterds | $943,820 | The Final Destination (#2), Year One (#9), The Dolphin: Story of a Dreamer (#10) |
| 42 | October 18, 2009 | $818,448 | District 9 (#2) |
| 43 | October 25, 2009 | Toy Story 3D | $905,458 | 9 (#2), REC 2 (#3) |
| 44 | November 1, 2009 | Michael Jackson's This Is It | $1,010,828 | Toy Story 2 3D (#2), Cirque du Freak: The Vampire's Assistant (#3), Gamer (#7), Halloween II (#9), Violanchelo (#10) |
| 45 | November 8, 2009 | Disney's A Christmas Carol | $2,086,795 | Couples Retreat (#3), Passengers (#8) |
| 46 | November 15, 2009 | 2012 | $5,126,644 | |
| 47 | November 22, 2009 | The Twilight Saga: New Moon | $6,107,021 | No-Do (#6) |
| 48 | November 29, 2009 | $2,868,961 | Planet 51 (#3), Old Dogs (#4), Morenita, el Escándalo (#6) |
| 49 | December 6, 2009 | $1,377,084 | Case 39 (#5) |
| 50 | December 13, 2009 | The Princess and the Frog | $1,341,861 | The Box (#7), The Stepfather (#9) |
| 51 | December 20, 2009 | Avatar | $4,998,010 | Nikté (#6) |
| 52 | December 27, 2009 | $5,222,003 | Alvin and the Chipmunks 2 (#2), Paranormal Activity (#3), Everybody's Fine (#6) |
