| # | Weekend End Date | Film | Box Office | Notes | Refs |
|---|
| 1 | 2 January 2000 | The World Is Not Enough | £797,142 | | [2] |
| 2 | 9 January 2000 | Sleepy Hollow | £2,848,933 | | [3] |
| 3 | 16 January 2000 | £1,739,653 | | [4] |
| 4 | 23 January 2000 | £1,170,710 | | [5] |
| 5 | 30 January 2000 | Double Jeopardy | £1,287,911 | | [6] |
| 6 | 6 February 2000 | American Beauty | £2,836,678 | American Beauty reached number one in its second weekend of release and had a record weekend for an 18-certificate film beating Alien Resurrection 's £2.7 million. | [7] [8] |
| 7 | 13 February 2000 | Toy Story 2 † | £7,758,936 | Toy Story 2, in its second week of release, had a record three-day weekend, beating Star Wars: Episode I – The Phantom Menace 's 3-day opening, excluding previews. | [9] [10] [11] |
| 8 | 20 February 2000 | £6,521,187 | | [12] |
| 9 | 27 February 2000 | £6,301,601 | | [13] |
| 10 | 5 March 2000 | £2,755,664 | | [14] |
| 11 | 12 March 2000 | £1,622,052 | | [15] |
| 12 | 19 March 2000 | £1,037,594 | | [16] [17] |
| 13 | 26 March 2000 | £732,926 | | [16] [18] |
| 14 | 2 April 2000 | Lake Placid | £931,472 | | [16] [19] |
| 15 | 9 April 2000 | Erin Brockovich | £1,609,930 | | [20] |
| 16 | 16 April 2000 | Pokémon: The First Movie | £2,833,721 | | [21] |
| 17 | 23 April 2000 | Kevin & Perry Go Large | £2,404,517 | | [22] |
| 18 | 30 April 2000 | Scream 3 | £2,449,937 | | [23] |
| 19 | 7 May 2000 | Kevin & Perry Go Large | £923,483 | Kevin & Perry Go Large returned to number one in its third week of release | [24] |
| 10 | 14 May 2000 | Gladiator | £3,555,446 | | [25] |
| 21 | 21 May 2000 | £3,459,104 | | [26] |
| 22 | 28 May 2000 | £2,987,696 | | [27] |
| 23 | 4 June 2000 | £2,073,765 | | [28] |
| 24 | 11 June 2000 | £1,401,766 | | [29] |
| 25 | 18 June 2000 | £613,491 | | [30] |
| 26 | 25 June 2000 | £976,300 | | [31] |
| 27 | 2 July 2000 | Chicken Run | £3,848,755 | | [32] |
| 28 | 9 July 2000 | Mission: Impossible 2 | £4,621,948 | | [33] |
| 29 | 16 July 2000 | Chicken Run | £2,573,372 | Chicken Run returned to number one in its third week of release | [34] |
| 30 | 23 July 2000 | Stuart Little | £1,694,498 | Stuart Little reached number one in its fourth week of release | [35] |
| 31 | 30 July 2000 | The Perfect Storm | £2,181,194 | | [36] |
| 32 | 6 August 2000 | Gone in 60 Seconds | £1,715,147 | | [37] |
| 33 | 13 August 2000 | £1,021,267 | | [38] |
| 34 | 20 August 2000 | X-Men | £4,749,241 | | [39] |
| 35 | 27 August 2000 | £2,026,544 | | [40] |
| 36 | 3 September 2000 | Snatch | £3,180,002 | Snatch beat American Beauty's record weekend for an 18-certificate film | [41] [8] |
| 37 | 10 September 2000 | Scary Movie | £3,191,096 | | [42] |
| 38 | 17 September 2000 | £1,460,710 | | [43] |
| 39 | 24 September 2000 | Me, Myself & Irene | £1,292,512 | | [44] |
| 40 | 1 October 2000 | Hollow Man | £1,634,386 | | [45] |
| 41 | 8 October 2000 | Nutty Professor II: The Klumps | £1,780,521 | | [46] [47] |
| 42 | 15 October 2000 | Dinosaur | £2,128,218 | | [46] [48] |
| 43 | 22 October 2000 | What Lies Beneath | £2,258,893 | | [46] [49] |
| 44 | 29 October 2000 | Dinosaur | £2,173,178 | Dinosaur returned to number one in its third week of release | [46] [50] |
| 45 | 5 November 2000 | What Lies Beneath | £1,341,518 | What Lies Beneath returned to number one in its third week of release | [51] [52] |
| 46 | 12 November 2000 | Bedazzled | £1,112,178 | | [51] [53] |
| 47 | 19 November 2000 | What Lies Beneath | £811,997 | What Lies Beneath returned to number one in its fifth week of release | [51] [54] |
| 48 | 26 November 2000 | Charlie's Angels | £3,182,114 | | [51] [55] |
| 49 | 3 December 2000 | How the Grinch Stole Christmas | £3,063,799 | | [56] |
| 50 | 10 December 2000 | £2,547,769 | | [57] |
| 51 | 17 December 2000 | Meet the Parents | £2,261,785 | | |
| 52 | 24 December 2000 | How the Grinch Stole Christmas | £1,588,377 | | |
| 53 | 31 December 2000 | Unbreakable | £2,002,862 | | [58] |
|