Sports
Baseball
- Mike Aldrete, first base coach for the Oakland Athletics of Major League Baseball
- Jim Andrews, Major League Baseball player
- Buddy Bell, manager in Major League Baseball and vice president and senior advisor to the general manager for the Cincinnati Reds
- Steve Buechele, current front office executive for the Texas Rangers
- Joe Conzelman, pitcher for the Pittsburgh Pirates [6]
- Shawn Green, Major League Baseball two-time All-Star right fielder [7] [8]
- Rick Helling, special assistant to the head of the Major League Baseball Players Association
- A. J. Hinch, Houston Astros manager and World Series champion in 2017
- Chad Hutchinson, pitcher for the St. Louis Cardinals and professional football player for the Dallas Cowboys and Chicago Bears
- Mark Marquess, head baseball coach at Stanford University
- Dave McCarty, former first baseman and outfielder in Major League Baseball
- Jake Miller, Major League Baseball pitcher [9]
- Russ Miller, Major League Baseball pitcher [10]
- Mike Mussina, Major League Baseball player for the Baltimore Orioles and the New York Yankees
- Branch Rickey, instrumental in breaking Major League Baseball's color barrier by signing black player Jackie Robinson, created the framework for the modern minor league farm system, and introduced the batting helmet
- Branch Rickey III, president of the Pacific Coast League
- Eppa Rixey, best known as the National League's leader in career victories for a left-hander with 266 wins
- Bo Schultz, former professional baseball pitcher
- George Sisler, elected to the National Baseball Hall of Fame in 1939
- Ed Sprague, only player ever to win the College World Series, an Olympic championship, and the World Series
- Drew Storen, former professional baseball relief pitcher
Basketball
- Mike Bratz, professional baskeball player and former the assistant general manager for the Sacramento Kings
- Pete Carril, former basketball coach at Princeton University
- E. R. Cowell, head basketball coach at Ottawa University and football coach at Sterling College
- Scott Drew, head basketball coach of Baylor University
- Rich Falk, former coach of the Northwestern Wildcats and associate commissioner of the Big Ten Conference
- Buck Harris, guard for the Virginia Cavaliers of the University of Virginia, won the 1900 championship and made the All-Southern Team in 1901
- Zach Kleiman, General manager of the Memphis Grizzlies, and won the NBA Executive of the Year Award 2021–2022
- Ward Lambert, head basketball coach at Purdue University
- Bobby Leonard, inducted into the Naismith Memorial Basketball Hall of Fame as a coach in 2014
- Ray Mears winningest basketball coach in University of Tennessee history
- Stretch Murphy, college and professional basketball player inducted into the Basketball Hall of Fame in 1960
- Ed Nealy, professional basketball player who won the NBA championship in 1993 as a member of the Chicago Bulls
- Andy Phillip, professional basketball player elected to the Naismith Memorial Basketball Hall of Fame in 1961
- Mike Phillips, professional basketball player
- Rick Robey, college and professional basketball player
- Justin Zanik, the general manager of the Utah Jazz
Football
- Joe Avezzano, head football coach at Oregon State University and assistant coach with the Dallas Cowboys and Oakland Raiders
- Enoch Brown, college football player
- Randy Bullock, college and professional football player
- William Caley, University of Colorado Boulder record holder and member of the undefeated 1898 Michigan Wolverines football team
- Carmen Cozza, head football coach at Yale University
- Irby Curry, All-Southern quarterback shot down over French skies in World War I
- Chris Dalman, former San Francisco 49ers offensive lineman and later offensive line coach
- Boyd Dowler, professional football player with the Green Bay Packers and Washington Redskins.
- Pos Elam, college football player
- John Elway, professional football quarterback and general manager with the Denver Broncos
- Jason Fisk, professional football plaery
- George W. Gregory, starting center for the University of Michigan's football team, winning 3 national championships
- Cale Gundy, assistant coach at the University of Oklahoma
- Dick Hartley, college football player
- Les Horvath, college football player who won the Heisman Trophy playing for the Ohio State Buckeyes
- J. W. Knibbs, head football coach at the University of California, Berkeley
- Dante Lavelli, professional football end for the Cleveland Browns
- Tuffy Leemans, professional football player with the New York Giants
- Erik Lorig, professional football player wtih the Tampa Bay Buccaneers and New Orleans Saints
- John Lynch, professional football player and the general manager of the San Francisco 49ers
- Owen Marecic, professional football player with the Cleveland Browns
- Herb McCracken, head football coach at Allegheny College
- Tot McCullough, college football and baseball player
- Howard Mudd, professional football player with the San Francisco 49ers and Chicago Bears and coachat the University of California
- Jess Neely, winningest football coach in Rice University and member of College Football Hall of Fame
- Kent Nix, professional football player
- Jim Parady, football coach at Marist College
- Jim Plunkett, professional football player with the Las Vegas Raiders
- Milton C. Portmann professional football played in the Ohio League
- Tavita Pritchard, quarterback coach for the Washington Commanders
- Jon Ritchie, professional football fullback and current sports radio host
- Greg Van Roten, professional football player for the New York Giants
- Mark Rypien, professional football player with the Washington Redskins named Super Bowl MVP
- Alfred Sharp, college football players
- Jeff Siemon professional football player with the Minnesota Vikings
- Billy Joe Tolliver, professional football player in the National Football League and Canadian Football League
- Stein Stone, head football coach of Clemson University
- Jeff Voris, football coach at Butler University
- Gene Washington, professional football player with the San Francisco 49ers and the Detroit Lions
- Dave Wyman, professional football player with the Seattle Seahawks and Denver Broncos
Horse racing
- Samuel S. Brown, Thoroughbred racehorse owner, breeder, and racetrack owner.
- John W. Galbreath, racehorse owner, breeder, and founder of Darby Dan Farm
- Bob Lewis, businessman who owned a number of champion Thoroughbred racehorses
- John T. Ward Jr., racehorse trainer.
Swimming and water polo
- Bob Bennett, competition swimmer, Olympic medalist, and former world record-holder
- Charles E. Collett, US Olympics 1924 water polo team and bronze medalist
- Ludy Langer, Olympic swimmer [11]
- Lance Larson, Olympic swimmer
- Roy Saari, swimmer and water polo Olympic medalist
Other sports
- Andy Banachowski, women's volleyball coach at UCLA
- Bruce Barnes, [12] high-ranking professional tennis player of the 1930s
- Scott Dunlap, American professional golfer
- Todd Martin, American tennis player
- Mark Mendelblatt, yachtsman
- David Mitchell, figure skater
- Al Oerter, four-time Olympic Champion in discus throw
- Kyle Rote Jr., professional soccer player
Sportscasters
- Tony Barnhart, college football insider for CBS Sports
- Steve Bunin, former ESPN Anchor
- Bill Flemming, television sports journalist and announcers for Wide World of Sports
- Bill Macatee, sports broadcaster for CBS Sports and Tennis Channel
- Jon Miller, sportscaster for Major League Baseball and play-by-play announcer for the San Francisco Giants
- Pat O'Brien, sportscaster with CBS Sports, anchor and host of Access Hollywood and The Insider
- Jay Randolph, sportscaster
- Craig Sager, sports reporter for CNN, TBS, and TNT
