Malassezia furfur

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Malassezia furfur
Malassezia furfur SEM lores.jpg
A scanning electron microscopy image of Malassezia furfur
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Basidiomycota
Class: Malasseziomycetes
Order: Malasseziales
Family: Malasseziaceae
Genus: Malassezia
Species:
M. furfur
Binomial name
Malassezia furfur
(C.P.Robin) Baill. (1889)
Synonyms
  • Microsporum furfurC.P.Robin (1853)

Malassezia furfur (formerly known as Pityrosporum ovale) is a species of yeast (a type of fungus) that is naturally found on the skin surfaces of humans and some other mammals. It is associated with a variety of dermatological conditions caused by fungal infections, notably seborrhoeic dermatitis and tinea versicolor. As an opportunistic pathogen, it has further been associated with dandruff, malassezia folliculitis, pityriasis versicolor (alba), and malassezia intertrigo, [1] as well as catheter-related fungemia and pneumonia in patients receiving hematopoietic transplants. The fungus can also affect animals, including dogs.

Contents

Background

Malassezia furfur is a fungus that lives on the superficial layers of the dermis. It generally exists as a commensal organism forming a natural part of the human skin microbiota, but it can gain pathogenic capabilities when morphing from a yeast to a hyphal form during its life cycle, through unknown molecular changes. [2] This can lead to its uncontrolled proliferation and a subsequent imbalance of the residential skin flora. Some virulence factors or properties which may increase the fungus' ability to acquire an infectious nature include the formation of biofilms, increased adherence to surfaces, and hydrophobicity and also can form hyphae (long, cylindrical filaments) [3]

Infections with pathogenic M. furfur occur on the trunk or the limbs and present clinically as pigmented macules that can merge in the form of scaling plaques. Many of these lesions resolve spontaneously in most patients. [2] The pathogen most frequently affects children compared to people of other age groups. [4] It has been associated with numerous dermatological conditions, including seborrhoeic dermatitis, dandruff, pityriasis versicolor, and tinea circinata, all of which affect the skin. [5] Some other diseases can also arise due to an infection with the fungus, such as catheter-related fungemia and pneumonia in patients receiving hematopoietic cell transplants. [6]

Morphology and characteristics

Malassezia furfur is a unicellular organism which varies in size between 1.5 and 4.5 × 2.0–6.5 micrometers. The cells have a bottle-like shape due to a small protrusion visible at the end of each cell. Cells are difficult to grow in a lab since they require specific conditions. [7]

Treatment

Topical application of antifungal medications such as ketoconazole, ciclopirox olamine, piroctone-olamine, zinc pyrithione, or sulfur compounds are commonly prescribed to treat diseases caused by Malassezia furfur. [5]

Related Research Articles

<span class="mw-page-title-main">Dandruff</span> Skin condition of the scalp

Dandruff is a skin condition that mainly affects the scalp. Symptoms include flaking and sometimes mild itchiness. It can result in social or self-esteem problems. A more severe form of the condition, which includes inflammation of the skin, is known as seborrhoeic dermatitis.

<span class="mw-page-title-main">Tinea cruris</span> Fungal infection

Tinea cruris, also known as jock itch, is a common type of contagious, superficial fungal infection of the groin and buttocks region, which occurs predominantly but not exclusively in men and in hot-humid climates.

<span class="mw-page-title-main">Tinea versicolor</span> Skin disease

Tinea versicolor is a condition characterized by a skin eruption on the trunk and proximal extremities. The majority of tinea versicolor is caused by the fungus Malassezia globosa, although Malassezia furfur is responsible for a small number of cases. These yeasts are normally found on the human skin and become troublesome only under certain circumstances, such as a warm and humid environment, although the exact conditions that cause initiation of the disease process are poorly understood.

<span class="mw-page-title-main">Seborrhoeic dermatitis</span> Skin disease

Seborrhoeic dermatitis is a long-term skin disorder. Symptoms include flaky, scaly, greasy, and occasionally itchy and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest. It can result in social or self-esteem problems. In babies, when the scalp is primarily involved, it is called cradle cap. Seborrhoeic dermatitis of the scalp may be described in lay terms as dandruff due to the dry, flaky character of the skin. However, as dandruff may refer to any dryness or scaling of the scalp, not all dandruff is seborrhoeic dermatitis. Seborrhoeic dermatitis is sometimes inaccurately referred to as seborrhoea.

<span class="mw-page-title-main">Zinc pyrithione</span> Chemical compound

Zinc pyrithione is a coordination complex of zinc. It has fungistatic and bacteriostatic properties and is used in the treatment of seborrhoeic dermatitis and dandruff.

<i>Malassezia</i> Genus of fungi

Malassezia is a genus of fungi. It is the sole genus in family Malasseziaceae, which is the only family in order Malasseziales, itself the single member of class Malasseziomycetes. Malassezia species are naturally found on the skin surfaces of many animals, including humans. In occasional opportunistic infections, some species can cause hypopigmentation or hyperpigmentation on the trunk and other locations in humans. Allergy tests for these fungi are available. It is believed French revolutionary Jean-Paul Marat suffered from a fungal infection from Malassezia restricta, which lead to his frequent bathing in a medicinal substance.

<span class="mw-page-title-main">Intertrigo</span> Medical condition

Intertrigo refers to a type of inflammatory rash (dermatitis) of the superficial skin that occurs within a person's body folds. These areas are more susceptible to irritation and subsequent infection due to factors that promote skin breakdown such as moisture, friction, and exposure to bodily secretions and excreta such as sweat, urine, or feces. Areas of the body which are more likely to be affected by intertrigo include the inframammary fold, intergluteal cleft, armpits, and spaces between the fingers or toes. Skin affected by intertrigo is more prone to infection than intact skin.

<span class="mw-page-title-main">Ciclopirox</span> Antifungal medication

Ciclopirox is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against tinea versicolor. It is often used clinically as ciclopirox olamine, the olamine salt of ciclopirox.

<span class="mw-page-title-main">Cradle cap</span> Human medical condition

Cradle cap causes crusty or oily scaly patches on a baby's scalp. The condition is not painful or itchy, but it can cause thick white or yellow scales that are not easy to remove. Cradle cap most commonly begins sometime in the first three months but can occur in later years. Similar symptoms in older children are more likely to be dandruff than cradle cap. The rash is often prominent around the ear, the eyebrows or the eyelids. It may appear in other locations as well, where it is called infantile seborrhoeic dermatitis. Cradle cap is just a special—and more benign—case of this condition. The exact cause of cradle cap is not known. Cradle cap is not spread from person to person (contagious). It is also not caused by poor hygiene. It is not an allergy, and it is not dangerous. Cradle cap often lasts a few months. In some children, the condition can last until age 2 or 3.

Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor. It is applied to the affected area as a lotion or shampoo. Symptoms frequently return if treatment is stopped.

<span class="mw-page-title-main">Butenafine</span> Chemical compound

Butenafine, sold under the brand names Lotrimin Ultra, Mentax, and Butop (India), is a synthetic benzylamine antifungal. It is structurally related to synthetic allylamine antifungals such as terbinafine.

Pityriasis alba is a skin condition, a type of dermatitis, commonly seen in children and young adults as dry, fine-scaled, pale patches on the face. It is self-limiting and usually only requires use of moisturizer creams.

<span class="mw-page-title-main">Tinea nigra</span> Medical condition

Tinea nigra, also known as superficial phaeohyphomycosis and Tinea nigra palmaris et plantaris, is a superficial fungal infection, a type of phaeohyphomycosis rather than a tinea, that causes usually a single 1–5 cm dark brown-black, non-scaly, flat, painless patch on the palms of the hands and the soles of the feet of healthy people. There may be multiple spots. The macules occasionally extend to the fingers, toes, and nails, and may be reported on the chest, neck, or genital area. Tinea nigra infections can present with multiple macules that can be mottled or velvety in appearance, and may be oval or irregular in shape. The macules can be anywhere from a few mm to several cm in size.

<span class="mw-page-title-main">Pityriasis amiantacea</span> Medical condition

Pityriasis amiantacea is an eczematous condition of the scalp in which thick tenaciously adherent scale infiltrates and surrounds the base of a group of scalp hairs. It does not result in scarring or alopecia.

<i>Malassezia globosa</i> Species of fungus

Malassezia globosa is a species of yeast-like fungus.

<span class="mw-page-title-main">Malassezia folliculitis</span> Medical condition

Malassezia folliculitis or Pityrosporum folliculitis, is a skin condition caused by infection by Malassezia yeast.

Malassezia pachydermatis is a zoophilic yeast in the division Basidiomycota. It was first isolated in 1925 by Fred Weidman, and it was named pachydermatis after the original sample taken from an Indian rhinoceros with severe exfoliative dermatitis. Within the genus Malassezia, M. pachydermatis is most closely related to the species M. furfur. A commensal fungus, it can be found within the microflora of healthy mammals such as humans, cats and dogs, However, it is capable of acting as an opportunistic pathogen under special circumstances and has been seen to cause skin and ear infections, most often occurring in canines.

Malassezia sympodialis is a species in the genus Malassezia. It is characterized by a pronounced lipophily, unilateral, percurrent or sympodial budding and an irregular, corrugated cell wall ultrastructure. It is one of the most common species found on the skin of healthy and diseased individuals. It is considered to be part of the skin's normal human microbiota and begins to colonize the skin of humans shortly after birth. Malassezia sympodialis, often has a symbiotic or commensal relationship with its host, but it can act as a pathogen causing a number of different skin diseases, such as atopic dermatitis.

Topical antifungaldrugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus. These drugs inhibit the production of ergosterol, which is a fundamental component of the fungal cell membrane and wall.

References

  1. Janniger, Camila K.; Schwartz, Robert A. (September 2005). "Intertrigo and Common Secondary Skin Infections". American Family Physician. 72 (5): 833–838. PMID   16156342. Archived from the original on 2021-01-26. Retrieved 2021-03-04.
  2. 1 2 Goering Hazel Dockrell, Richard; L. Chiodini, Peter; M. Roitt, Ivan; Zuckerman, Mark (2012). Mims' Medical Microbiology (5 ed.). Elsevier Health Sciences. p. 345. ISBN   9780723436010.
  3. Angiolella, L; Leone, C; Rojas, F; Mussin, J; de los Angeles Sosa, M; Giusiano, G. (2017). "Biofilm, adherence, and hydrophobicity as virulence factors in Malassezia furfur". Medical Mycology. 56 (1): 110–116. doi: 10.1093/mmy/myx014 . PMID   28340187.
  4. A, Prohic; Sadikovic T, Jovovic; Krupalija-Fazlic, M; Kuskunovic-Vlahovljak, S. (2015). "Malasseziaspecies in healthy skin and in dermatological conditions". International Journal of Dermatology. 55 (5): 494–504. doi:10.1111/ijd.13116. PMID   26710919. S2CID   205190325.
  5. 1 2 Schmidt, A. (1996). "Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders". Cutis. 59 (1): 21–24. ISSN   0011-4162. PMID   9013067.
  6. Croitoru, A; Chen, H; Ramos-e-Silva, M; Busam, K. (2010). "Infectious Diseases of the Skin". Dermatopathology: 105–183. doi:10.1016/B978-0-443-06654-2.00003-2. ISBN   9780443066542.
  7. Larone 2002 , p. 136

Bibliography