Mannan-binding lectin-associated serine protease-2

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Mannan-binding lectin-associated serine protease-2
Identifiers
EC no. 3.4.21.104
CAS no. 214915-16-9
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Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme. [1] [2] [3] [4] [5] [6] [7] This enzyme catalyses the following chemical reaction

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.

References

  1. ↑ Matsushita M, Fujita T (December 1992). "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease". The Journal of Experimental Medicine. 176 (6): 1497–502. doi:10.1084/jem.176.6.1497. PMC   2119445 . PMID   1460414.
  2. ↑ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature. 386 (6624): 506–10. Bibcode:1997Natur.386..506T. doi:10.1038/386506a0. PMID   9087411.
  3. ↑ Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ (November 2001). "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2". The Journal of Biological Chemistry. 276 (44): 40880–7. doi: 10.1074/jbc.M105934200 . PMID   11527969.
  4. ↑ Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P (February 2003). "Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments". Journal of Immunology. 170 (3): 1374–82. doi: 10.4049/jimmunol.170.3.1374 . PMID   12538697.
  5. ↑ Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P (October 2004). "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions". Journal of Molecular Biology. 342 (5): 1533–46. doi:10.1016/j.jmb.2004.07.014. PMID   15364579.
  6. ↑ Chen CB, Wallis R (June 2004). "Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases". The Journal of Biological Chemistry. 279 (25): 26058–65. doi: 10.1074/jbc.M401318200 . PMID   15060079.
  7. ↑ Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM (March 2005). "The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases". Journal of Immunology. 174 (5): 2870–7. doi: 10.4049/jimmunol.174.5.2870 . PMID   15728497.
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