Molybdopterin-synthase adenylyltransferase

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Molybdopterin-synthase adenylyltransferase
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EC no. 2.7.7.80
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Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80, MoeB, adenylyltransferase and sulfurtransferase MOCS3) is an enzyme with systematic name ATP:molybdopterin-synthase adenylyltransferase. [1] [2] This enzyme catalyses the following chemical reaction

ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP

This enzyme adenylates the C-terminus of the small subunit of the molybdopterin synthase.

Related Research Articles

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References

  1. Leimkühler S, Wuebbens MM, Rajagopalan KV (September 2001). "Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor". The Journal of Biological Chemistry. 276 (37): 34695–701. doi: 10.1074/jbc.M102787200 . PMID   11463785.
  2. Matthies A, Nimtz M, Leimkühler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID   15910006.