Pancreatic elastase II

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Pancreatic elastase II
Identifiers
EC no. 3.4.21.71
CAS no. 75603-19-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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NCBI proteins

Pancreatic elastase II (EC 3.4.21.71, pancreatic elastase 2) is an enzyme. [1] [2] This enzyme catalyses the following chemical reaction

Preferential cleavage: Leu-, Met- and Phe-. Hydrolyses elastin

This peptidase from trypsin family is formed by activation of proelastase II from mammalian pancreas by trypsin.

References

  1. Fletcher TS, Shen WF, Largman C (November 1987). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID   3427074.
  2. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A (December 1987). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". Journal of Biochemistry. 102 (6): 1555–63. doi: 10.1093/oxfordjournals.jbchem.a122204 . PMID   2834346.