Phosphomethylpyrimidine kinase

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phosphomethylpyrimidine kinase
Identifiers
EC no. 2.7.4.7
CAS no. 37278-18-5
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MetaCyc metabolic pathway
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In enzymology, a phosphomethylpyrimidine kinase (EC 2.7.4.7) is an enzyme that catalyzes the chemical reaction

ATP + (4-amino-2-methylpyrimidin-5-yl)methyl phosphate ADP + (4-amino-2-methylpyrimidin-5-yl)methyl diphosphate

Thus, the two substrates of this enzyme are ATP and (4-amino-2-methylpyrimidin-5-yl)methyl phosphate, whereas its two products are ADP and (4-amino-2-methylpyrimidin-5-yl)methyl diphosphate.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(4-amino-2-methylpyrimidin-5-yl)methyl-phosphate phosphotransferase. Other names in common use include hydroxymethylpyrimidine phosphokinase, and ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase. This enzyme participates in thiamine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1JXH, 1JXI, 1UB0, and 2I5B.

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References


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