Protein-fructosamine 3-kinase

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Protein-fructosamine 3-kinase
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EC no. 2.7.1.171
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Protein-fructosamine 3-kinase (EC 2.7.1.171, FN3K , fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-fructosyl-L-lysine 3-phosphotransferase. [1] [2] This enzyme catalyses the following chemical reaction

ATP + [protein]-N6-D-fructosyl-L-lysine ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine

Nonenzymatic glycation is a factor in the pathogenesis of diabetes.

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<span class="mw-page-title-main">Fructosamine-3-kinase</span> Protein-coding gene in the species Homo sapiens

Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene.

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3-Deoxyglucosone (3DG) is a sugar that is notable because it is a marker for diabetes. 3DG reacts with protein to form advanced glycation end-products (AGEs), which contribute to diseases such as the vascular complications of diabetes, atherosclerosis, hypertension, Alzheimer's disease, inflammation, and aging.

In molecular biology the fructosamine kinase family is a family of enzymes. This family includes eukaryotic fructosamine-3-kinase enzymes which may initiate a process leading to the deglycation of fructoselysine and of glycated proteins and in the phosphorylation of 1-deoxy-1-morpholinofructose, fructoselysine, fructoseglycine, fructose and glycated lysozyme. The family also includes ketosamine-3-kinases (KT3K). Ketosamines derive from a non-enzymatic reaction between a sugar and a protein. Ketosamine-3-kinases (KT3K) catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degradation, and KT3K is thus thought to be involved in protein repair.

Octanoyl-(GcvH):protein N-octanoyltransferase (EC 2.3.1.204, LIPL, octanoyl-[GcvH]:E2 amidotransferase, YWFL (gene)) is an enzyme with systematic name (glycine cleavage system H)-N6-octanoyl-L-lysine:(lipoyl-carrier protein)-N6-L-lysine octanoyltransferase. This enzyme catalyses the following chemical reaction

Protein-ribulosamine 3-kinase (EC 2.7.1.172, FN3KRP, FN3K-related protein, FN3K-RP, ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-ribulosyl-L-lysine 3-phosphotransferase. This enzyme catalyses the following chemical reaction

References

  1. Szwergold BS, Howell S, Beisswenger PJ (September 2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes. 50 (9): 2139–47. doi: 10.2337/diabetes.50.9.2139 . PMID   11522682.
  2. Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E (October 2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes. 49 (10): 1627–34. doi:10.2337/diabetes.49.10.1627. PMID   11016445.