Signal peptidase I

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Signal peptidase I
Identifiers
EC no. 3.4.21.89
CAS no. 65979-36-4
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Signal peptidase I (EC 3.4.21.89, leader peptidase I, signal proteinase, Escherichia coli leader peptidase, eukaryotic signal peptidase, eukaryotic signal proteinase, leader peptidase, leader peptide hydrolase, leader proteinase, signal peptidase , pilin leader peptidase, SPC, prokaryotic signal peptidase, prokaryotic leader peptidase, HOSP, prokaryotic signal proteinase, propeptidase, PuIO prepilin peptidase, signal peptide hydrolase, signal peptide peptidase , signalase, bacterial leader peptidase 1) is an enzyme. [1] [2] [3] [4] [5] [6] [7] This enzyme catalyses the following chemical reaction

Cleavage of hydrophobic, N-terminal signal or leader sequences

This enzyme is present in bacterial membranes and in chloroplast thylakoid membranes.

References

  1. ↑ Black MT (August 1993). "Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad". Journal of Bacteriology. 175 (16): 4957–61. doi:10.1128/jb.175.16.4957-4961.1993. PMC   204959 . PMID   8394311.
  2. ↑ Nunnari J, Fox TD, Walter P (December 1993). "A mitochondrial protease with two catalytic subunits of nonoverlapping specificities". Science. 262 (5142): 1997–2004. doi:10.1126/science.8266095. PMID   8266095.
  3. ↑ Tschantz WR, Sung M, Delgado-Partin VM, Dalbey RE (December 1993). "A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase". The Journal of Biological Chemistry. 268 (36): 27349–54. doi: 10.1016/S0021-9258(19)74256-2 . PMID   8262975.
  4. ↑ Lively MO, Newsome AL, Nusier M (1994). "Eukaryote microsomal signal peptidases". Proteolytic Enzymes: Serine and Cysteine Peptidases. Methods in Enzymology. Vol. 244. pp. 301–14. doi:10.1016/0076-6879(94)44024-7. ISBN   978-0-12-182145-6. PMID   7845216.
  5. ↑ Tschantz WR, Dalbey RE (1994). "Bacterial leader peptidase 1". Proteolytic Enzymes: Serine and Cysteine Peptidases. Methods in Enzymology. Vol. 244. pp. 285–301. doi:10.1016/0076-6879(94)44023-9. ISBN   978-0-12-182145-6. PMID   7845215.
  6. ↑ Chaal BK, Mould RM, Barbrook AC, Gray JC, Howe CJ (January 1998). "Characterization of a cDNA encoding the thylakoidal processing peptidase from Arabidopsis thaliana. Implications for the origin and catalytic mechanism of the enzyme". The Journal of Biological Chemistry. 273 (2): 689–92. doi: 10.1074/jbc.273.2.689 . PMID   9422718.
  7. ↑ Inoue K, Baldwin AJ, Shipman RL, Matsui K, Theg SM, Ohme-Takagi M (November 2005). "Complete maturation of the plastid protein translocation channel requires a type I signal peptidase" (PDF). The Journal of Cell Biology. 171 (3): 425–30. doi: 10.1083/jcb.200506171 . PMC   2171254 . PMID   16275749.
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