Terminal nerve

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Terminal nerve
Lawrence 1960 1.3.png
Left The terminal nerve as it is shown on the ventral side of a dog-fish brain. (Topmost label)
Details
Identifiers
Latin nervus terminalis
TA98 A14.2.01.002
TA2 6179
FMA 76749
Anatomical terminology

The terminal nerve, also known as cranial nerve zero or simply as CN 0, is a nerve that was not included in the seminal classification of the cranial nerves as CN I through CN XII, but has since been recognized and listed in TA2. [1] It was discovered by German scientist Gustav Fritsch in 1878 in the brains of sharks, and was first found in humans in 1913. [2] Studies have confirmed that the terminal nerve is a common finding in the adult human brain. [3] [4]

Contents

The accepted name of terminal nerve is due to its entrance in the lamina terminalis regions. [1] The nerve has previously been called cranial nerve XIII, zero nerve, nerve N, and NT. [5] [6]

Structure

The original images (1878) of Fritsch's dogfish shark brain showing the nerve marked by an asterisk Fritsch dogfish shark brain.png
The original images (1878) of Fritsch's dogfish shark brain showing the nerve marked by an asterisk

The terminal nerve appears just in front of the other cranial nerves and would, if earlier recognized, have been classified as cranial nerve one. It first appears bilaterally as a microscopic plexus of unmyelinated peripheral nerve fibers in the subarachnoid space covering the straight gyrus. The plexus appears near the cribriform plate and travels posteriorly toward the olfactory trigone and lamina terminalis. [3]

The terminal nerve is clearly seen in the human embryo but loses some of its ganglion cells before birth making it less recognizable in adults. [7] The nerve is therefore often overlooked in autopsies, and is often torn out upon exposing the brain. [5] Careful dissection is necessary to visualize the nerve.

Development

The zebrafish was used as a developmental model in research from 2004. [8]

The connections between the terminal nerve and the olfactory system have been extensively studied in human embryos. Olfactory nerve fibers enter the brain at stage 17, vomeronasal fibers and fibers of the terminal nerve enter the brain at stages 17 and 18. [9] During prenatal development some of the ganglion cells are lost. [7]

Function

The functions of the terminal nerve are only speculated on together with possible pathological implications. [1] Although very close to the olfactory nerve, the terminal nerve is not connected to the olfactory bulb, where smells are analyzed. This suggests that the nerve is either vestigial or may be related to the sensing of pheromones. [10] The nerve may modulate olfactory inputs making pheromones more detectable. [1] This hypothesis is further supported by the fact that the terminal nerve projects to the medial and lateral septal nuclei and the preoptic areas, all of which are involved in reproduction in mammals, [2] A 1987 study found that mating in hamsters is reduced when the terminal nerve is severed. [11]

Clinical significance

Alterations in the terminal nerve structure may be implicated in Kallmann syndrome. [7] [12]

Additional images

See also

Related Research Articles

<span class="mw-page-title-main">Cranial nerves</span> Nerves that emerge directly from the brain and the brainstem

Cranial nerves are the nerves that emerge directly from the brain, of which there are conventionally considered twelve pairs. Cranial nerves relay information between the brain and parts of the body, primarily to and from regions of the head and neck, including the special senses of vision, taste, smell, and hearing.

<span class="mw-page-title-main">Olfactory nerve</span> Cranial nerve I, for smelling

The olfactory nerve, also known as the first cranial nerve, cranial nerve I, or simply CN I, is a cranial nerve that contains sensory nerve fibers relating to the sense of smell.

<span class="mw-page-title-main">Abducens nerve</span> Cranial nerve VI, for eye movements

The abducens nerve or abducent nerve, also known as the sixth cranial nerve, cranial nerve VI, or simply CN VI, is a cranial nerve in humans and various other animals that controls the movement of the lateral rectus muscle, one of the extraocular muscles responsible for outward gaze. It is a somatic efferent nerve.

Articles related to anatomy include:

<span class="mw-page-title-main">Oculomotor nerve</span> Cranial nerve III, for eye movements

The oculomotor nerve, also known as the third cranial nerve, cranial nerve III, or simply CN III, is a cranial nerve that enters the orbit through the superior orbital fissure and innervates extraocular muscles that enable most movements of the eye and that raise the eyelid. The nerve also contains fibers that innervate the intrinsic eye muscles that enable pupillary constriction and accommodation. The oculomotor nerve is derived from the basal plate of the embryonic midbrain. Cranial nerves IV and VI also participate in control of eye movement.

<span class="mw-page-title-main">Vomeronasal organ</span> Smell sense organ above the roof of the mouth

The vomeronasal organ (VNO), or Jacobson's organ, is the paired auxiliary olfactory (smell) sense organ located in the soft tissue of the nasal septum, in the nasal cavity just above the roof of the mouth in various tetrapods. The name is derived from the fact that it lies adjacent to the unpaired vomer bone in the nasal septum. It is present and functional in all snakes and lizards, and in many mammals, including cats, dogs, cattle, pigs, and some primates. Some humans may have physical remnants of a VNO, but it is vestigial and non-functional.

<span class="mw-page-title-main">Nasal cavity</span> Large, air-filled space above and behind the nose in the middle of the face

The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The nasal septum divides the cavity into two cavities, also known as fossae. Each cavity is the continuation of one of the two nostrils. The nasal cavity is the uppermost part of the respiratory system and provides the nasal passage for inhaled air from the nostrils to the nasopharynx and rest of the respiratory tract.

<span class="mw-page-title-main">Orbit (anatomy)</span> Cavity or socket of the skull in which the eye and its appendages are situated

In anatomy, the orbit is the cavity or socket/hole of the skull in which the eye and its appendages are situated. "Orbit" can refer to the bony socket, or it can also be used to imply the contents. In the adult human, the volume of the orbit is 30 millilitres, of which the eye occupies 6.5 ml. The orbital contents comprise the eye, the orbital and retrobulbar fascia, extraocular muscles, cranial nerves II, III, IV, V, and VI, blood vessels, fat, the lacrimal gland with its sac and duct, the eyelids, medial and lateral palpebral ligaments, cheek ligaments, the suspensory ligament, septum, ciliary ganglion and short ciliary nerves.

<span class="mw-page-title-main">Olfactory system</span> Sensory system used for smelling

The olfactory system or sense of smell is the sensory system used for smelling (olfaction). Olfaction is one of the special senses, that have directly associated specific organs. Most mammals and reptiles have a main olfactory system and an accessory olfactory system. The main olfactory system detects airborne substances, while the accessory system senses fluid-phase stimuli.

<span class="mw-page-title-main">Cribriform plate</span> Part of the ethmoid bone in the skull

In mammalian anatomy, the cribriform plate, horizontal lamina or lamina cribrosa is part of the ethmoid bone. It is received into the ethmoidal notch of the frontal bone and roofs in the nasal cavities. It supports the olfactory bulb, and is perforated by olfactory foramina for the passage of the olfactory nerves to the roof of the nasal cavity to convey smell to the brain. The foramina at the medial part of the groove allow the passage of the nerves to the upper part of the nasal septum while the foramina at the lateral part transmit the nerves to the superior nasal concha.

<span class="mw-page-title-main">Sixth nerve palsy</span> Medical condition

Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve VI, which is responsible for causing contraction of the lateral rectus muscle to abduct the eye. The inability of an eye to turn outward, results in a convergent strabismus or esotropia of which the primary symptom is diplopia in which the two images appear side-by-side. Thus, the diplopia is horizontal and worse in the distance. Diplopia is also increased on looking to the affected side and is partly caused by overaction of the medial rectus on the unaffected side as it tries to provide the extra innervation to the affected lateral rectus. These two muscles are synergists or "yoke muscles" as both attempt to move the eye over to the left or right. The condition is commonly unilateral but can also occur bilaterally.

<span class="mw-page-title-main">Anterior cranial fossa</span>

The anterior cranial fossa is a depression in the floor of the cranial base which houses the projecting frontal lobes of the brain. It is formed by the orbital plates of the frontal, the cribriform plate of the ethmoid, and the small wings and front part of the body of the sphenoid; it is limited behind by the posterior borders of the small wings of the sphenoid and by the anterior margin of the chiasmatic groove. The lesser wings of the sphenoid separate the anterior and middle fossae.

<span class="mw-page-title-main">Olfactory tract</span> Part of the olfactory system

The olfactory tract is a bilateral bundle of afferent nerve fibers from the mitral and tufted cells of the olfactory bulb that connects to several target regions in the brain, including the piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward.

<span class="mw-page-title-main">Human nose</span> Feature of the human face

The human nose is the first organ of the respiratory system. It is also the principal organ in the olfactory system. The shape of the nose is determined by the nasal bones and the nasal cartilages, including the nasal septum, which separates the nostrils and divides the nasal cavity into two.

<span class="mw-page-title-main">Straight gyrus</span>

The portion of the inferior frontal lobe immediately adjacent to the longitudinal fissure is named the straight gyrus,(or gyrus rectus) and is continuous with the superior frontal gyrus on the medial surface.

<span class="mw-page-title-main">Outline of human anatomy</span> Overview of and topical guide to human anatomy

The following outline is provided as an overview of and topical guide to human anatomy:

The rostral neuropore or anterior neuropore is a region corresponding to the opening of the embryonic neural tube in the anterior portion of the developing prosencephalon. The central nervous system develops from the neural tube, which initially starts as a plate of cells in the ectoderm and this is called the neural plate, the neural plate then undergoes folding and starts closing from the center of the developing fetus, this leads to two open ends, one situated cranially/rostrally and the other caudally. Bending of the neural plate begins on day 22, and the cranial neuropore closes on day 24. giving rise to the lamina terminalis of the brain.

<span class="mw-page-title-main">Outline of the human nervous system</span> Overview of and topical guide to the human nervous system

The following diagram is provided as an overview of and topical guide to the human nervous system:

References

  1. 1 2 3 4 Ruqa WA, Pennacchia F, Rusi E, Zoccali F, Bruno G, Talarico G, Barbato C, Minni A (March 2024). "Smelling TNT: Trends of the Terminal Nerve". Int J Mol Sci. 25 (7): 3920. doi: 10.3390/ijms25073920 . PMC   11011448 . PMID   38612730.
  2. 1 2 Fields, R. Douglas (2007). "Sex and the Secret Nerve". Scientific American Mind. 18: 20–7. doi:10.1038/scientificamericanmind0207-20.
  3. 1 2 Fuller GN, Burger PC (1990). "Nervus terminalis (cranial nerve zero) in the adult human". Clinical Neuropathology. 9 (6): 279–83. PMID   2286018. The presence of an additional cranial nerve (the nervus terminalis or cranial nerve zero) is well documented in many non-human vertebrate species. However, its existence in the adult human has been disputed. The present study focused on the structure and incidence of this nerve in the adult human brain. The nerve was examined post-mortem in 10 adult brains using dissection microscopy, light microscopy, transmission electron microscopy, and immuno­histo­chemistry. In all specimens, the nervus terminalis was identified bilaterally as a microscopic plexus of unmyelinated peripheral nerve fascicles in the subarachnoid space covering the gyrus rectus of the orbital surface of the frontal lobes. The plexus appeared in the region of the cribriform plate of the ethmoid and coursed posteriorly to the vicinity of the olfactory trigone, medial olfactory gyrus, and lamina terminalis. We conclude that the terminal nerve is a common finding in the adult human brain, confirming early light microscopic reports.
  4. Berman, Laura (March 25, 2008). "Scientists discover secret sex nerve". TODAY.com . Archived from the original on June 27, 2019. Retrieved June 27, 2019.
  5. 1 2 Bordoni, Bruno; Zanier, Emiliano (March 13, 2013). "Cranial nerves XIII and XIV: nerves in the shadows". Journal of Multidisciplinary Healthcare. 6. Dove Medical Press: 87–91. doi: 10.2147/JMDH.S39132 . eISSN   1178-2390. ISSN   1178-2390. OCLC   319595339. PMC   3601045 . PMID   23516138.
  6. Vilensky, JA (January 2014). "The neglected cranial nerve: nervus terminalis (cranial nerve N)". Clinical Anatomy. 27 (1): 46–53. doi:10.1002/ca.22130. PMID   22836597. S2CID   21454488.
  7. 1 2 3 Peña-Melián Á, Cabello-de la Rosa JP, Gallardo-Alcañiz MJ, Vaamonde-Gamo J, Relea-Calatayud F, González-López L, Villanueva-Anguita P, Flores-Cuadrado A, Saiz-Sánchez D, Martínez-Marcos A (March 2019). "Cranial Pair 0: The Nervus Terminalis". Anat Rec (Hoboken). 302 (3): 394–404. doi:10.1002/ar.23826. PMID   29663690.
  8. Whitlock KE (September 2004). "Development of the nervus terminalis: origin and migration". Microscopy Research and Technique. 65 (1–2): 2–12. doi: 10.1002/jemt.20094 . PMID   15570589. S2CID   8736656.
  9. Müller F, O'Rahilly R (2004). "Olfactory structures in staged human embryos". Cells Tissues Organs. 178 (2): 93–116. doi:10.1159/000081720. PMID   15604533. S2CID   43056268.
  10. Von Bartheld CS (September 2004). "The terminal nerve and its relation with extrabulbar "olfactory" projections: lessons from lampreys and lungfishes". Microscopy Research and Technique. 65 (1–2): 13–24. doi: 10.1002/jemt.20095 . PMID   15570592.
  11. Wirsig, Celeste (11 August 1987). "Terminal nerve damage impairs the mating behavior of the male hamster". Brain Research. 417 (2): 293–303. doi:10.1016/0006-8993(87)90454-9. PMID   3308003. S2CID   33371658.
  12. Taroc EZ, Naik AS, Lin JM, Peterson NB, Keefe DL, Genis E, Fuchs G, Balasubramanian R, Forni PE (January 2020). "Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration". J Neurosci. 40 (2): 311–326. doi:10.1523/JNEUROSCI.1977-19.2019. PMC   6948949 . PMID   31767679.