Mesencephalic nucleus of trigeminal nerve

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Mesencephalic nucleus of trigeminal nerve
Gray696.png
The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue. (Trigeminal nerve nuclei are at "V".)
Details
Identifiers
Latin nucleus mesencephalicus nervi trigemini
NeuroNames 558
NeuroLex ID birnlex_1010
TA98 A14.1.05.409
TA2 5887
FMA 54568
Anatomical terms of neuroanatomy

The mesencephalic nucleus of trigeminal nerve is one of the sensory nuclei of the trigeminal nerve (cranial nerve V). It is located in the brainstem. It receives proprioceptive sensory information from the muscles of mastication and other muscles of the head and neck. It is involved in processing information about the position of the jaw/teeth. It is functionally responsible for preventing excessive biting that may damage the dentition, regulating tooth pain perception, and mediating the jaw jerk reflex (by means of projecting to the motor nucleus of the trigeminal nerve). [1]

Contents

The axons of the neuron cell bodies of this nucleus provide sensory innervation to target tissues directly, whereas other sensory nuclei of the trigeminal nerve receive their sensory inputs by synapsing with primary sensory neurons in the trigeminal ganglion. [1]

Anatomy

The MNTN is located in the brainstem, more specifically (sources vary) spanning the length of the midbrain [2] /in the caudal midbrain and rostral pons. [1] It is situated (sources vary) near [1] /within [2] the periaqueductal gray, lateral to the cerebral aqueduct. [2]

The mesencephalic nucleus is the only structure in the central nervous system to contain the cell bodies of first order sensory neurons. [2] The mesencephalic nucleus can thus be considered functionally as a primary sensory ganglion embedded within the brainstem, [1] making it neuroanatomically unique. [3]

Microanatomy

Unlike many nuclei within the central nervous system (CNS), the mesencephalic nucleus contains no chemical synapses, neurons instead being electrically coupled. [4] Neurons of this nucleus are pseudounipolar, receiving proprioceptive afferent information from the mandible and sending efferent projections to the trigeminal motor nucleus to mediate the monosynaptic jaw jerk reflex. [5]

Development

The pseudounipolar neurons in the mesencephalic nucleus are embryologically derived from the neural crest. However, instead of joining the trigeminal ganglion, the neurons migrate into the brainstem. [6] [7] The MNTN neurons directly receive sensory information, akin to neurons in the dorsal root ganglia.

Function

The MNTN is involved in reflex proprioception of the periodontium [8] and of the muscles of mastication in the jaw [9] that functions to prevent biting down hard enough to lose a tooth. To subserve this reflex protective function, mechanoreceptive nerves in the periodontal ligament sense tooth movement and project to the mesencephalic nucleus. Likewise, afferent fibers from muscle spindles, the sensory organs of skeletal muscle, are stimulated by the stretch of hard contraction of jaw muscles. The temporomandibular joint receptors and the Golgi tendon organs of the jaw muscles do not project to the mesencephalic nucleus. [10] The mesencephalic nucleus is one of four trigeminal nerve nuclei, three sensory and one motor. The other two sensory nuclei are the chief sensory nucleus mediating conscious facial touch and the spinal trigeminal nucleus, mediating pain and temperature in the head, and is of importance in headache. The trigeminal motor nucleus innervates the muscles of mastication, mylohyoid, anterior belly of digastric, tensor veli palatini, and tensor tympani.

Clinical significance

Clinically, because of its reflex function, the mesencephalic nucleus can be tested with the jaw jerk reflex. Because of its function in oral proprioception, lesions of the trigeminal mesencephalic nucleus cause effects on feeding. [11] The mesencephalic nucleus can be thought of simply as the "nucleus that keeps your teeth in" by preventing one from biting down hard enough to lose a tooth on foods containing e.g. bone, cherry seeds, apricot stones etc.

See also

Related Research Articles

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<span class="mw-page-title-main">Trigeminal nerve</span> Cranial nerve responsible for the faces senses and motor functions

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<span class="mw-page-title-main">Mandibular nerve</span> Branch of the trigeminal nerve responsible for the lower face and jaw

In neuroanatomy, the mandibular nerve (V3) is the largest of the three divisions of the trigeminal nerve, the fifth cranial nerve (CN V). Unlike the other divisions of the trigeminal nerve (ophthalmic nerve, maxillary nerve) which contain only afferent fibers, the mandibular nerve contains both afferent and efferent fibers. These nerve fibers innervate structures of the lower jaw and face, such as the tongue, lower lip, and chin. The mandibular nerve also innervates the muscles of mastication.

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<span class="mw-page-title-main">Afferent nerve fiber</span> Axonal projections that arrive at a particular brain region

Afferent nerve fibers are axons of sensory neurons that carry sensory information from sensory receptors to the central nervous system. Many afferent projections arrive at a particular brain region.

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The spinothalamic tract is a nerve tract in the anterolateral system in the spinal cord. This tract is an ascending sensory pathway to the thalamus. From the ventral posterolateral nucleus in the thalamus, sensory information is relayed upward to the somatosensory cortex of the postcentral gyrus.

<span class="mw-page-title-main">Dorsal column–medial lemniscus pathway</span> Sensory spinal pathway

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<span class="mw-page-title-main">Reticular formation</span> Spinal trigeminal nucleus

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<span class="mw-page-title-main">Edinger–Westphal nucleus</span> One of two nuclei of the oculomotor nerve

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The jaw jerk reflex or the masseter reflex is a stretch reflex used to test the status of a patient's trigeminal nerve and to help distinguish an upper cervical cord compression from lesions that are above the foramen magnum. The mandible—or lower jaw—is tapped at a downward angle just below the lips at the chin while the mouth is held slightly open. In response, the masseter muscles will jerk the mandible upwards. Normally this reflex is absent or very slight. However, in individuals with upper motor neuron lesions the jaw jerk reflex can be quite pronounced.

<span class="mw-page-title-main">Pseudounipolar neuron</span> Type of neuron

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<span class="mw-page-title-main">Cranial nerve nucleus</span>

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<span class="mw-page-title-main">Trigeminal motor nucleus</span>

The trigeminal motor nucleus contains motor neurons that innervate muscles of the first branchial arch, namely the muscles of mastication, the tensor tympani, tensor veli palatini, mylohyoid, and anterior belly of the digastric. It is situated in the upper pons, inferior to the lateral part of the floor of the fourth ventricle.

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<span class="mw-page-title-main">Dorsal nucleus of vagus nerve</span>

The dorsal nucleus of vagus nerve is a cranial nerve nucleus of the vagus nerve situated in the medulla oblongata of the brainstem ventral to the floor of the fourth ventricle. It contains nerve cell bodies of parasympathetic neurons of CN X that provide parasympathetic innervation to the gastrointestinal tract and lungs as well as other thoracic and abdominal organs. These functions include, among others, bronchoconstriction and gland secretion.

References

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