Mesencephalic nucleus of trigeminal nerve

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Mesencephalic nucleus of trigeminal nerve
Gray696.png
The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue. (Trigeminal nerve nuclei are at "V".)
Details
Identifiers
Latin nucleus mesencephalicus nervi trigemini
NeuroNames 558
NeuroLex ID birnlex_1010
TA98 A14.1.05.409
TA2 5887
FMA 54568
Anatomical terms of neuroanatomy

The mesencephalic nucleus of trigeminal nerve is one of the sensory nuclei of the trigeminal nerve (cranial nerve V). It is located in the brainstem. It receives proprioceptive sensory information from the muscles of mastication and other muscles of the head and neck. It is involved in processing information about the position of the jaw/teeth. It is functionally responsible for preventing excessive biting that may damage the dentition, regulating tooth pain perception, and mediating the jaw jerk reflex (by means of projecting to the motor nucleus of the trigeminal nerve). [1]

Contents

The axons of the neuron cell bodies of this nucleus provide sensory innervation to target tissues directly, whereas other sensory nuclei of the trigeminal nerve receive their sensory inputs by synapsing with primary sensory neurons in the trigeminal ganglion. [1]

Anatomy

The MNTN is located in the brainstem, more specifically (sources vary) spanning the length of the midbrain [2] /in the caudal midbrain and rostral pons. [1] It is situated (sources vary) near [1] /within [2] the periaqueductal gray, lateral to the cerebral aqueduct. [2]

The mesencephalic nucleus is the only structure in the central nervous system to contain the cell bodies of first order sensory neurons. [2] The mesencephalic nucleus can thus be considered functionally as a primary sensory ganglion embedded within the brainstem, [1] making it neuroanatomically unique.[ citation needed ]

Microanatomy

Unlike many nuclei within the central nervous system (CNS), the mesencephalic nucleus contains no chemical synapses but are electrically coupled. [3] Neurons of this nucleus are pseudounipolar, receiving proprioceptive afferent information from the mandible and sending efferent projections to the trigeminal motor nucleus to mediate monosynaptic jaw jerk reflexes.[ citation needed ]

Development

The pseudounipolar neurons in the mesencephalic nucleus are embryologically derived from the neural crest. However, instead of joining the trigeminal ganglion, the neurons migrate into the brainstem.[ citation needed ] The MNTN is believed to represent a primary sensory ganglion akin to a dorsal root ganglion that becomes incorporated into the brainstem during embryologic development. [1]

Function

The MNTN is involved in reflex proprioception of the periodontium [4] and of the muscles of mastication in the jaw [5] that functions to prevent biting down hard enough to lose a tooth. To subserve this reflex protective function, mechanoreceptive nerves in the periodontal ligament sense tooth movement and project to the mesencephalic nucleus. Likewise, afferent fibers from muscle spindles, the sensory organs of skeletal muscle, are stimulated by the stretch of hard contraction of jaw muscles. The temporomandibular joint receptors and the Golgi tendon organs of the jaw muscles do not project to the mesencephalic nucleus. [6] The mesencephalic nucleus is one of four trigeminal nerve nuclei, three sensory and one motor. The other two sensory nuclei are the chief sensory nucleus mediating conscious facial touch and the spinal trigeminal nucleus, mediating pain and temperature in the head, and is of importance in headache. The trigeminal motor nucleus innervates the muscles of mastication, mylohyoid, anterior belly of digastric, tensor veli palatini, and tensor tympani.

Clinical significance

Clinically, because of its reflex function, the mesencephalic nucleus can be tested with the jaw jerk reflex. Because of its function in oral proprioception, lesions of the trigeminal mesencephalic nucleus cause effects on feeding. [7] The mesencephalic nucleus can be thought of simply as the "nucleus that keeps your teeth in" by preventing one from biting down hard enough to lose a tooth on foods containing eg. bone, cherry seeds, apricot stones etc.

See also

Related Research Articles

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A ganglion is a group of neuron cell bodies in the peripheral nervous system. In the somatic nervous system this includes dorsal root ganglia and trigeminal ganglia among a few others. In the autonomic nervous system there are both sympathetic and parasympathetic ganglia which contain the cell bodies of postganglionic sympathetic and parasympathetic neurons respectively.

<span class="mw-page-title-main">Medulla oblongata</span> Structure of the brain stem

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<span class="mw-page-title-main">Facial nerve</span> Cranial nerve VII, for the face and tasting

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Articles related to anatomy include:

<span class="mw-page-title-main">Trigeminal nerve</span> Cranial nerve responsible for the faces senses and motor functions

In neuroanatomy, the trigeminal nerve (lit. triplet nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for sensation in the face and motor functions such as biting and chewing; it is the most complex of the cranial nerves. Its name (trigeminal, from Latin tri- 'three', and -geminus 'twin') derives from each of the two nerves (one on each side of the pons) having three major branches: the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3). The ophthalmic and maxillary nerves are purely sensory, whereas the mandibular nerve supplies motor as well as sensory (or "cutaneous") functions. Adding to the complexity of this nerve is that autonomic nerve fibers as well as special sensory fibers (taste) are contained within it.

<span class="mw-page-title-main">Glossopharyngeal nerve</span> Cranial nerve IX, for the tongue and pharynx

The glossopharyngeal nerve, also known as the ninth cranial nerve, cranial nerve IX, or simply CN IX, is a cranial nerve that exits the brainstem from the sides of the upper medulla, just anterior to the vagus nerve. Being a mixed nerve (sensorimotor), it carries afferent sensory and efferent motor information. The motor division of the glossopharyngeal nerve is derived from the basal plate of the embryonic medulla oblongata, whereas the sensory division originates from the cranial neural crest.

<span class="mw-page-title-main">Mandibular nerve</span> Branch of the trigeminal nerve responsible for the lower face and jaw

In neuroanatomy, the mandibular nerve (V3) is the largest of the three divisions of the trigeminal nerve, the fifth cranial nerve (CN V). Unlike the other divisions of the trigeminal nerve (ophthalmic nerve, maxillary nerve) which contain only afferent fibers, the mandibular nerve contains both afferent and efferent fibers. These nerve fibers innervate structures of the lower jaw and face, such as the tongue, lower lip, and chin. The mandibular nerve also innervates the muscles of mastication.

<span class="mw-page-title-main">Afferent nerve fiber</span> Axonal projections that arrive at a particular brain region

Afferent nerve fibers are axons of sensory neurons that carry sensory information from sensory receptors to the central nervous system. Many afferent projections arrive at a particular brain region.

<span class="mw-page-title-main">Spinothalamic tract</span> Sensory pathway from the skin to the thalamus

The spinothalamic tract is a part of the anterolateral system or the ventrolateral system, a sensory pathway to the thalamus. From the ventral posterolateral nucleus in the thalamus, sensory information is relayed upward to the somatosensory cortex of the postcentral gyrus.

<span class="mw-page-title-main">Dorsal column–medial lemniscus pathway</span> Sensory spinal pathway

The dorsal column–medial lemniscus pathway (DCML) is a sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception from the skin and joints. It transmits information from the body to the primary somatosensory cortex in the postcentral gyrus of the parietal lobe of the brain. The pathway receives information from sensory receptors throughout the body, and carries this in nerve tracts in the white matter of the dorsal column of the spinal cord to the medulla, where it is continued in the medial lemniscus, on to the thalamus and relayed from there through the internal capsule and transmitted to the somatosensory cortex. The name dorsal-column medial lemniscus comes from the two structures that carry the sensory information: the dorsal columns of the spinal cord, and the medial lemniscus in the brainstem.

<span class="mw-page-title-main">Solitary nucleus</span> Sensory nuclei in medulla oblongata

In the human brainstem, the solitary nucleus, also called nucleus of the solitary tract, nucleus solitarius, and nucleus tractus solitarii, is a series of purely sensory nuclei forming a vertical column of grey matter embedded in the medulla oblongata. Through the center of the SN runs the solitary tract, a white bundle of nerve fibers, including fibers from the facial, glossopharyngeal and vagus nerves, that innervate the SN. The SN projects to, among other regions, the reticular formation, parasympathetic preganglionic neurons, hypothalamus and thalamus, forming circuits that contribute to autonomic regulation. Cells along the length of the SN are arranged roughly in accordance with function; for instance, cells involved in taste are located in the rostral part, while those receiving information from cardio-respiratory and gastrointestinal processes are found in the caudal part.

The jaw jerk reflex or the masseter reflex is a stretch reflex used to test the status of a patient's trigeminal nerve and to help distinguish an upper cervical cord compression from lesions that are above the foramen magnum. The mandible—or lower jaw—is tapped at a downward angle just below the lips at the chin while the mouth is held slightly open. In response, the masseter muscles will jerk the mandible upwards. Normally this reflex is absent or very slight. However, in individuals with upper motor neuron lesions the jaw jerk reflex can be quite pronounced.

<span class="mw-page-title-main">Pseudounipolar neuron</span>

A pseudounipolar neuron is a type of neuron which has one extension from its cell body. This type of neuron contains an axon that has split into two branches. A single process arises from the cell body and then divides into an axon and a dendrite. They develop embryologically as bipolar in shape, and are thus termed pseudounipolar instead of unipolar.

<span class="mw-page-title-main">Cranial nerve nucleus</span>

A cranial nerve nucleus is a collection of neurons in the brain stem that is associated with one or more of the cranial nerves. Axons carrying information to and from the cranial nerves form a synapse first at these nuclei. Lesions occurring at these nuclei can lead to effects resembling those seen by the severing of nerve(s) they are associated with. All the nuclei except that of the trochlear nerve supply nerves of the same side of the body.

<span class="mw-page-title-main">Trigeminal motor nucleus</span>

The trigeminal motor nucleus contains motor neurons that innervate muscles of the first branchial arch, namely the muscles of mastication, the tensor tympani, tensor veli palatini, mylohyoid, and anterior belly of the digastric. It is situated in the upper pons, inferior to the lateral part of the floor of the fourth ventricle.

<span class="mw-page-title-main">Superior ganglion of vagus nerve</span>

The superior ganglion of the vagus nerve, (jugular ganglion) is a sensory ganglion of the peripheral nervous system. It is located within the jugular foramen, where the vagus nerve exits the skull. It is smaller than and proximal to the inferior ganglion of the vagus nerve.

<span class="mw-page-title-main">Inferior ganglion of vagus nerve</span> Ganglion of the peripheral nervous system

The inferior ganglion of the vagus nerve is one of the two sensory ganglia of each vagus nerve. It contains neuron cell bodies of general visceral efferent fibers and special visceral efferent fibers. It is situated within the jugular fossa just below the skull. It is situated just below the superior ganglion of vagus nerve.

<span class="mw-page-title-main">Dorsal column nuclei</span> Nuclei in the dorsal column of the brainstem

In neuroanatomy, the dorsal column nuclei are a pair of nuclei in the dorsal columns in the brainstem. The name refers collectively to the cuneate nucleus and gracile nucleus, which are situated at the lower end of the medulla oblongata. Both nuclei contain second-order neurons of the dorsal column–medial lemniscus pathway, which convey fine touch and proprioceptive information from the body to the brain. The dorsal column nuclei project to the thalamus.

<span class="mw-page-title-main">Proprioception</span> Sense of self-movement, force, and body position

Proprioception, also called kinaesthesia, is the sense of self-movement, force, and body position.

<span class="mw-page-title-main">Roots of the ciliary ganglion</span>

The ciliary ganglion is a parasympathetic ganglion located just behind the eye in the posterior orbit. Three types of axons enter the ciliary ganglion but only the preganglionic parasympathetic axons synapse there. The entering axons are arranged into three roots of the ciliary ganglion, which join enter the posterior surface of the ganglion.

References

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