Solitary nucleus

Solitary nucleus
The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue.
Transverse section of medulla oblongata of human embryo.
Details
Identifiers
Latin	nucleus tractus solitarii medullae oblongatae
MeSH	D017552
NeuroNames	742
NeuroLex ID	birnlex_1429
TA98	A14.1.04.230
TA2	6008
FMA	72242
Anatomical terms of neuroanatomy [ edit on Wikidata]

The solitary nucleus(SN) (nucleus of the solitary tract, nucleus solitarius, or nucleus tractus solitarii) is a series of neurons whose cell bodies form a roughly vertical column of grey matter in the medulla oblongata of the brainstem. Their axons form the bulk of the enclosed solitary tract. The solitary nucleus can be divided into different parts including dorsomedial, dorsolateral, and ventrolateral subnuclei. ^[1]

The solitary nucleus receives general visceral and special visceral inputs from the facial nerve (CN VII), glossopharyngeal nerve (CN IX) and vagus nerve (CN X); it receives and relays stimuli related to taste and visceral sensation. It sends outputs to various parts of the brain, such as the hypothalamus, thalamus, and reticular formation, forming circuits that contribute to autonomic regulation.

Cells along the length of the SN are arranged roughly in accordance with function; for instance, cells involved in taste are located in the rostral part, while those receiving information from cardio-respiratory and gastrointestinal processes are found in the caudal part. ^{[2] [3]} The cells involved in taste are the part of the solitary nucleus referred to as the gustatory nucleus. ^[4]

Anatomy

The solitary nucleus is a series of neurons in the medulla oblongata. Their cell bodies form a roughly vertical column of grey matter in the medulla oblongata. Their axons form an enclosed nerve tract called the solitary tract.

Viscerotopic organization

Neurons of the SN are notably functionally arranged roughly length-wise along the nucleus: gustatory neurons are situated rostrally (with afferents from the anterior part of the tongue and roof of oral cavity rostral-most, and those from the larynx and epiglottis more caudally placed); gastrointestinal, cardiovascular, respiratory neurons are situated more caudally. However, some localization/organization also occurs along the ventro-dorsal and medio-lateral axes. ^[5]

Afferents

• Gustatory (taste) sensation from facial nerve (CN VII) via the chorda tympani (from anterior 2/3 of tongue), glossopharyngeal nerve (CN IX) (from posterior 1/3 of tongue), and vagus nerve (CN X) (from epiglottis).^{[ citation needed ]}
• Chemoreceptors and mechanoreceptors of the general visceral afferent pathway (GVA) from the carotid body and carotid sinus via (the carotid sinus nerve of) CN IX; from aortic bodies and aortic arch via CN X.
• Chemoreceptors and mechanoreceptors of the general visceral afferent pathway (GVA) with endings located in the heart, lungs, airways, gastrointestinal system, pharynx, and liver via the glossopharyngeal and vagus nerves. Organ specific regions of neuronal architecture are preserved in the solitary nucleus. ^[6] Additional minor GVA input from the nasal cavity, soft palate and sinus cavities enters via the facial nerve. ^[7]

Non-sensory afferent projections include:

• medial zone of hypothalamus → dorsal longitudinal fasciculus → periaqueductal gray → autonomic input of solitary nucleus ^{[8] : 451}

Efferents

The solitary nucleus projects to numerous regions of the CNS, including:

• thalamus (mediates autonomic responses, ^[3] conscious taste sensation,^{[ citation needed ]} conscious visceral sensations like stomach fullness/emptiness ^[9] )
  • (medial-most portion of) ventral posteromedial nucleus of thalamus → (via third-order neuron) sensory cortex and insular cortex ^[5]
• paraventricular nucleus of ^[10] hypothalamus → limbic system ^[5] (mediates autonomic responses) ^{[3] [5]}
• reticular formation (mediates autonomic responses) ^{[3] [5]}
• parasympathetic preganglionic neurons (for autonomic responses) ^[3]
• central nucleus of the amygdala ^[10]
• parabrachial area ^[10]
• locus coeruleus ^[10]
• dorsal raphe nucleus ^[10]
• solitariospinal tract → upper levels of spinal cord ^[5]
• other visceral motor or respiratory centers ^[10]

The SN projects to multiple other cranial nerve nuclei: ^[11]

• salivatory nuclei
• hypoglossal nucleus
• dorsal nucleus of vagus nerve
• nucleus ambiguus (to mediate gag reflex)

Function

Afferents of the SN mediate the gag reflex, the carotid sinus reflex, the aortic reflex, the cough reflex, the baroreflex and chemoreceptor reflexes, several respiratory reflexes and reflexes within the gastrointestinal system regulating motility and secretion.^{[ citation needed ]}

Neurons which transmit signals about the gut wall, the stretch of the lungs, and the dryness of mucous membranes also innervate the SN. The first central neurons within the SN can participate in simple autonomic reflexes.^{[ citation needed ]}

Gag reflex arc

The afferent limb of the gag reflex arc is conveyed by sensory afferents of the CN IX which terminate in the SN; the SN then projects to the nucleus ambiguus which in turn gives rise to motor efferent fibers of the CN IX/X which then mediate the efferent limb of the arc. ^[11]

Additional images

• 
  Section of the medulla oblongata at about the middle of the olive.
• 
  Primary terminal nuclei of the afferent (sensory) cranial nerves schematically represented; lateral view.

References

1. Carpenter, Malcolm B. (1985). Core text of neuroanatomy (3rd ed.). Baltimore: Williams & Wilkins. pp. 124–125. ISBN   0683014552.
2. Haines, Duane (2018). Fundamental neuroscience for basic and clinical applications (Fifth ed.). Philadelphia, PA: Elsevier. p. 201. ISBN   9780323396325.
3. P. Michael Conn (2008). Neuroscience in Medicine. Springer. p. 264. ISBN   978-1-60327-455-5 . Retrieved 22 January 2013.
4. Carpenter, Malcolm Breckenridge (1985). Core text of neuroanatomy (3. ed.). Baltimore: Williams & Wilkins. p. 151. ISBN   0683014552.
5. Standring, Susan (2020). Gray's Anatomy: The Anatomical Basis of Clinical Practice (42th ed.). New York: Elsevier. p. 449. ISBN   978-0-7020-7707-4. OCLC   1201341621.
6. Ran, C.; Boettcher, J.C.; Kaye, J.A. (2022). "A brainstem map for visceral sensations". Nature. 609 (7926): 320–326. Bibcode:2022Natur.609..320R. doi: 10.1038/s41586-022-05139-5 . PMC   9452305 . PMID   36045291.
7. Dulak, Dominika; Naqvi, Imama A (2020). Neuroanatomy, Cranial Nerve 7 (Facial). StatPearls Publishing. PMID   30252375 . Retrieved 2018-10-27.
8. Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. ISBN   978-1-118-67746-9.
9. Kiernan, John A.; Rajakumar, Nagalingam (2013). Barr's The Human Nervous System: An Anatomical Viewpoint (10th ed.). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins. p. 137. ISBN   978-1-4511-7327-7.
10. Carlson, Neil R. (2010). Physiology of Behavior (10th ed.). Allyn & Bacon. p. 253. ISBN   978-0-205-66627-0.
11. Duane E. Haines (2004). Neuroanatomy: An Atlas of Structures, Sections, and Systems. Lippincott Williams & Wilkins. pp. 186–. ISBN   978-0-7817-4677-9 . Retrieved 22 January 2013.

External links

• Stained brain slice images which include the "solitary tract" at the BrainMaps project