1-Aminotetralin

1-Aminotetralin

Names
IUPAC name 1,2,3,4-tetrahydronaphthalen-1-amine
Other names 1-AT; 1-Amino-1,2,3,4-tetrahydronaphthalene
Identifiers
CAS Number	2217-40-5  Y
3D model (JSmol)	Interactive image
ChemSpider	17067
ECHA InfoCard	100.017.012
EC Number	220-973-7
PubChem CID	18066
UNII	O7A3GV2PNX
CompTox Dashboard (EPA)	DTXSID70903059
InChI InChI=1S/C10H13N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7,11H2 Key: JRZGPXSSNPTNMA-UHFFFAOYSA-N
SMILES C1CC(C2=CC=CC=C2C1)N
Properties
Chemical formula	C10H13N
Molar mass	147.221 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

1-Aminotetralin (1-AT), also known as 1-amino-1,2,3,4-tetrahydronaphthalene, is a chemical compound and one of the possible positional isomers of aminotetralin. ^[1] It consists of a tetralin core with an amino substituent on one of the carbon atoms.

Derivatives

1-Aminotetralin is the parent structure of a number of drugs, including the following: ^[2]

• Dasotraline
• Desmethylsertraline
• Ethonam
• Lometraline
• LP-12
• LP-44
• Sertraline
• SR 59230A
• Tametraline
• Tochergamine

Tramazoline is another related compound. ^[2]

See also

• 2-Aminotetralin
• Aminoindane

References

1. Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. p. 263. ISBN   978-3-03788-700-4. OCLC   858805226.
2. Shah, Bhumi M.; Kachhadiya, Radhika N. (2025). "Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives". Medicinal Chemistry Research. 34 (1): 86–113. doi:10.1007/s00044-024-03331-y. ISSN   1054-2523.

External links

• 1-Aminotetralin - Isomer Design