4-hydroxybenzoate 4-O-beta-D-glucosyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.4.1.194 | ||||||||
CAS no. | 120860-68-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase (EC 2.4.1.194) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are UDP-glucose and 4-hydroxybenzoate, whereas its two products are UDP and 4-(beta-D-glucosyloxy)benzoate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase, UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid, glucosyltransferase, HBA glucosyltransferase, p-hydroxybenzoate glucosyltransferase, PHB glucosyltransferase, and PHB-O-glucosyltransferase.
4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It is isomeric with 2-hydroxybenzoic acid, known as salicylic acid, a precursor to aspirin, and with 3-hydroxybenzoic acid.
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