Adenosylcobinamide-GDP ribazoletransferase

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Adenosylcobinamide-GDP ribazoletransferase
Identifiers
EC no. 2.7.8.26
CAS no. 137672-85-6
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Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase. [1] [2] [3] This enzyme catalyses the following chemical reaction

Contents

(1) adenosylcobinamide-GDP + alpha-ribazole GMP + adenosylcobalamin
(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate GMP + adenosylcobalamin 5'-phosphate

This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.

See also

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References

  1. Maggio-Hall LA, Escalante-Semerena JC (October 1999). "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11798–803. Bibcode:1999PNAS...9611798M. doi: 10.1073/pnas.96.21.11798 . PMC   18366 . PMID   10518530.
  2. Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports. 19 (4): 390–412. doi:10.1039/b108967f. PMID   12195810.
  3. Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M, Cauchois L, Thibaut D, Debussche L, Crouzet J (October 1991). "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase". Journal of Bacteriology. 173 (19): 6066–73. doi:10.1128/jb.173.19.6066-6073.1991. PMC   208353 . PMID   1917841.