Deoxyguanosine kinase

Last updated
deoxyguanosine kinase
Identifiers
EC no. 2.7.1.113
CAS no. 39471-28-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

See DGUOK for a more thorough description of the human deoxyguanosine kinase.

Contents

Description of the catalyzed reaction and general features of deoxyguanosine kinases

In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction

ATP + deoxyguanosine ADP + dGMP

Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2JAQ, 2JAS, 2JAT, and 2OCP.

Clinical

Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia.

Related Research Articles

<span class="mw-page-title-main">1-phosphofructokinase</span> InterPro Family

In enzymology, 1-phosphofructokinase is an enzyme that catalyzes the chemical reaction

In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a cytidylate kinase is an enzyme that catalyzes the chemical reaction

Deoxynucleoside kinases are generally grouped into two families based on structural homology:

In enzymology, a dephospho-CoA kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an erythritol kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Gluconokinase</span>

In enzymology, a gluconokinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Glutamate 5-kinase</span> Enzyme

In enzymology, a glutamate 5-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerate kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Guanylate kinase</span> Enzyme

In enzymology, a guanylate kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Homoserine kinase</span> Enzyme

In enzymology, a homoserine kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol-tetrakisphosphate 1-kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acylmannosamine kinase</span>

In enzymology, a N-acylmannosamine kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a polynucleotide 5'-hydroxyl-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a protein-histidine tele-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a pyridoxal kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Riboflavin kinase</span> Class of enzymes

In enzymology, a riboflavin kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a S-methyl-5-thioribose kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an UMP kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Uridine kinase</span> Class of enzymes

In enzymology, an uridine kinase is an enzyme that catalyzes the chemical reaction

References


    This page is based on this Wikipedia article
    Text is available under the CC BY-SA 4.0 license; additional terms may apply.
    Images, videos and audio are available under their respective licenses.