IL1RAP

Last updated

IL1RAP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL1RAP , C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs OMIM: 602626; MGI: 104975; HomoloGene: 1643; GeneCards: IL1RAP; OMA:IL1RAP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159317
NM_001159318
NM_008364
NM_134103

RefSeq (protein)

NP_001152789
NP_001152790
NP_032390
NP_598864

Location (UCSC) Chr 3: 190.51 – 190.66 Mb Chr 16: 26.4 – 26.55 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. [5] [6] [7]

Contents

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. [7]

Interactions

IL1RAP has been shown to interact with TOLLIP [8] and Interleukin 1 receptor, type I. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196083 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022514 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID   9479509.
  6. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi: 10.1074/jbc.272.12.7727 . PMID   9065432.
  7. 1 2 "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
  8. Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN   1465-7392. PMID   10854325. S2CID   32036101.
  9. Huang J, Gao X, Li S, Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi: 10.1073/pnas.94.24.12829 . ISSN   0027-8424. PMC   24223 . PMID   9371760.

Further reading