Limulus clotting factor B

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Limulus clotting factor B
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EC no. 3.4.21.85
CAS no. 848851-53-6
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Limulus clotting factor B (EC 3.4.21.85) is an enzyme. [1] This enzyme catalyses the following chemical reaction

Selective cleavage of -Arg98-Ile- bond in limulus proclotting enzyme to form active clotting enzyme

From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. This enzyme is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme. [2]

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<span class="mw-page-title-main">Amplexus</span> Type of mating behavior exhibited by some externally fertilizing species

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<span class="mw-page-title-main">Atlantic horseshoe crab</span> Species of arthropod

The Atlantic horseshoe crab, also known as the American horseshoe crab, is a species of horseshoe crab, a kind of marine and brackish chelicerate arthropod. It is found in the Gulf of Mexico and along the Atlantic coast of North America. The main area of annual migration is Delaware Bay along the South Jersey Delaware Bayshore.

<span class="mw-page-title-main">Horseshoe crab</span> Order of arthropods

Horseshoe crabs are marine and brackish water arthropods of the family Limulidae and the only living members of the order Xiphosura. Despite their name, they are not true crabs or crustaceans: they are chelicerates, most closely related to arachnids such as spiders, ticks, and scorpions.

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Xiphosura is an order of arthropods related to arachnids. They are more commonly known as horseshoe crabs. They first appeared in the Hirnantian. Currently, there are only four living species. Xiphosura contains one suborder, Xiphosurida, and several stem-genera.

<i>Limulus</i> Genus of horseshoe crabs

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<i>Tachypleus</i> Genus of horseshoe crab relatives

Tachypleus is a genus of south, southeast and east Asian horseshoe crabs in the family Limulidae.

<i>Tachypleus tridentatus</i> Species of arthropod

Tachypleus tridentatus, commonly known as the Chinese horseshoe crab, Japanese horseshoe crab, or tri-spine horseshoe crab, is a species of horseshoe crab found in Southeast and East Asia, with records from China, Indonesia, Japan, South Korea, Malaysia, the Philippines, Taiwan, and Vietnam. It is found in coastal marine and brackish waters, and tolerates colder temperatures than the other Asian horseshoe crabs, although juveniles still need water warmer than 22 °C (72 °F) to moult.

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<i>Tachypleus gigas</i> Species of arthropod

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<span class="mw-page-title-main">Fred Bang</span> Medical researcher

Frederik Barry Bang (1916–1981) was an American medical researcher who developed the Limulus amebocyte lysate (LAL) test for bacterial endotoxins. He was influential in applying marine biology to medical research, especially immunology.

H. Jane Brockmann is an emeritus professor at the University of Florida known for her research on animal behavior, especially in the mating and nesting behavior of horseshoe crabs. In 2008, she was elected a fellow of the American Association for the Advancement of Science.

References

  1. Nakamura T, Horiuchi T, Morita T, Iwanaga S (March 1986). "Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes". Journal of Biochemistry. 99 (3): 847–57. doi:10.1093/oxfordjournals.jbchem.a135545. PMID   3519594.
  2. Iwanaga, S (May 2007). "Biochemical principle of Limulus test for detecting bacterial endotoxins". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 83 (4): 110–9. Bibcode:2007PJAB...83..110I. doi:10.2183/pjab.83.110. PMC   3756735 . PMID   24019589.