Limulus clotting factor B

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Limulus clotting factor B
Identifiers
EC no. 3.4.21.85
CAS no. 848851-53-6
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NCBI proteins

Limulus clotting factor B (EC 3.4.21.85) is an enzyme. [1] This enzyme catalyses the following chemical reaction:

Selective cleavage of -Arg98-Ile99- bond in limulus proclotting enzyme to form active clotting enzyme

This enzyme is present in the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, factor B is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme. [2]

References

  1. Nakamura T, Horiuchi T, Morita T, Iwanaga S (March 1986). "Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes". Journal of Biochemistry. 99 (3): 847–57. doi: 10.1093/oxfordjournals.jbchem.a135545 . PMID   3519594.
  2. Iwanaga, S (May 2007). "Biochemical principle of Limulus test for detecting bacterial endotoxins". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 83 (4): 110–9. Bibcode:2007PJAB...83..110I. doi:10.2183/pjab.83.110. PMC   3756735 . PMID   24019589.