PIGV

PIGV
Identifiers
Aliases	PIGV , GPI-MT-II, HPMRS1, PIG-V, phosphatidylinositol glycan anchor biosynthesis class V
External IDs	OMIM: 610274 MGI: 2442480 HomoloGene: 5354 GeneCards: PIGV
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.11 Start 26,787,472 bp [1] End 26,798,398 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.3 Start 133,387,698 bp [2] End 133,399,958 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm oocyte germinal epithelium bronchial epithelial cell secondary oocyte parotid gland kidney tubule palpebral conjunctiva right lobe of liver seminal vesicula Top expressed in interventricular septum ascending aorta aortic valve spermatocyte yolk sac hand proximal tubule otolith organ knee joint utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mannosyltransferase activity glycosyltransferase activity transferase activity glycolipid mannosyltransferase activity Cellular component membrane mannosyltransferase complex endoplasmic reticulum integral component of membrane endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane mannosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55650 230801 Ensembl ENSG00000060642 ENSMUSG00000043257 UniProt Q9NUD9 Q7TPN3 RefSeq (mRNA) NM_017837 NM_001202554 NM_001145955 NM_001145956 NM_178698 NM_001356466 RefSeq (protein) NP_001189483 NP_060307 NP_001361407 NP_001361409 NP_001361410 NP_001361411 NP_001361412 NP_001361413 NP_001361414 NP_001361415 NP_001139427 NP_001139428 NP_848813 NP_001343395 Location (UCSC) Chr 1: 26.79 – 26.8 Mb Chr 4: 133.39 – 133.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene. ^{[5] [6]}

See also

• Hyperphosphatasia with mental retardation syndrome (HPMRS)

References

1. GRCh38: Ensembl release 89: ENSG00000060642 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043257 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T (Mar 2005). "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol". J Biol Chem. 280 (10): 9489–97. doi: 10.1074/jbc.M413867200 . PMID   15623507.
6. "Entrez Gene: PIGV phosphatidylinositol glycan anchor biosynthesis, class V".

Further reading

• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Fabre AL, Orlean P, Taron CH (2005). "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly". FEBS J. 272 (5): 1160–8. doi: 10.1111/j.1742-4658.2005.04551.x . PMID   15720390. S2CID   25106178.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.