Phosphatidate cytidylyltransferase

Last updated
phosphatidate cytidylyltransferase
Identifiers
EC no. 2.7.7.41
CAS no. 9067-83-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins
Cytidylyltransferase family
Identifiers
SymbolCTP_transf_1
Pfam PF01148
InterPro IPR000374
PROSITE PDOC01019
OPM superfamily 414
OPM protein 4q2e
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

Phosphatidate cytidylyltransferase (EC 2.7.7.41) [1] [2] [3] (also known as CDP- diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from cytidine triphosphate and phosphatidate.

CTP + phosphatidate diphosphate + CDP-diacylglycerol

Thus, the two substrates of this enzyme are cytidine triphosphate, or CTP, and phosphatidate, whereas its two products are diphosphate and CDP-diacylglycerol.

CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:phosphatidate cytidylyltransferase. Other names in common use include CDP diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDP-diacylglyceride synthetase, cytidine diphosphoglyceride pyrophosphorylase, phosphatidate cytidyltransferase, phosphatidic acid cytidylyltransferase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synthetase, DAG synthetase, and CDP-DG. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.

Related Research Articles

<span class="mw-page-title-main">Deoxycytidine diphosphate</span> Chemical compound

Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose removed, and with one fewer phosphoryl group than CTP.

<span class="mw-page-title-main">CTP synthetase</span> Enzyme

CTP synthase is an enzyme involved in pyrimidine biosynthesis that interconverts UTP and CTP.

Carbamoyl phosphate synthetase (glutamine-hydrolysing) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol. Its systemic name is hydrogen-carbonate:L-glutamine amido-ligase .

In enzymology, a phosphopantothenate—cysteine ligase also known as phosphopantothenoylcysteine synthetase (PPCS) is an enzyme that catalyzes the chemical reaction which constitutes the second of five steps involved in the conversion of pantothenate to Coenzyme A. The reaction is:

<span class="mw-page-title-main">Cystathionine gamma-synthase</span>

In enzymology, a cystathionine gamma-synthase is an enzyme that catalyzes the formation of cystathionine from cysteine and an activated derivative of homoserine, e.g.:

<span class="mw-page-title-main">ATP phosphoribosyltransferase</span> Class of enzymes

In enzymology, an ATP phosphoribosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</span> Class of enzymes

In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction:

In enzymology, a 3-deoxy-manno-octulosonate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">CDP-diacylglycerol—inositol 3-phosphatidyltransferase</span>

In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

Choline-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a D-ribitol-5-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucose-1-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerol-3-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acylneuraminate cytidylyltransferase</span>

In enzymology, a N-acylneuraminate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

CCA tRNA nucleotidyltransferase is an enzyme with systematic name CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">CDS2</span> Protein-coding gene in the species Homo sapiens

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.

<span class="mw-page-title-main">CDS1 (gene)</span> Protein-coding gene in the species Homo sapiens

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.

<span class="mw-page-title-main">CDP-choline pathway</span>

The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid phosphatidylethanolamine (PE).

The PI(4,5)P2 cycle or simply PIP2 cycle (also known as PI cycle in past) is one of the important signalling cascades underlying many cellular functions including GPCR signaling, cytokinesis, endocytosis, and apoptosis.

References

  1. ↑ Sparrow CP, Raetz CR (1985). "Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli". Journal of Biological Chemistry. 260 (22): 12084–12091. doi: 10.1016/S0021-9258(17)38989-5 . PMID   2995359.
  2. ↑ Shen H, Heacock PN, Clancey CJ, Dowhan W (1996). "The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth". Journal of Biological Chemistry. 271 (2): 789–795. doi: 10.1074/jbc.271.2.789 . PMID   8557688.
  3. ↑ Kondo H, Goto K, Saito S, Tonosaki A (1997). "Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain". Journal of Biological Chemistry. 272 (14): 9503–9509. doi: 10.1074/jbc.272.14.9503 . PMID   9083091.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.