The pulvinar nuclei or nuclei of the pulvinar (nuclei pulvinares) are the nuclei (cell bodies of neurons) located in the thalamus (a part of the vertebrate brain).[1] As a group they make up the collection called the pulvinar of the thalamus (pulvinar thalami), usually just called the pulvinar.
The pulvinar is usually grouped as one of the lateral thalamic nuclei in rodents and carnivores, and stands as an independent complex in primates.
Pulvinar acts as an association nucleus that, along with medial dorsal nucleus, connected with parietal, occipital, and temporal lobes, but the function is largely unknown. No distinctive syndrome or obvious sensory deficit can be linked to either one.[2]
Structure
By convention, the pulvinar is divided into four nuclei:
The pulvinar also has input from the superior colliculus to inferior, lateral and medial sections, which seems to be important in the initiation and compensation of saccade,[4][5] as well as the regulation of visual attention[6][7]
Clinical significance
No distinctive syndrome or obvious sensory deficit can be linked to the pulvinar.[2] Lesions of the pulvinar can result in neglect syndromes and attentional deficits.[8] In addition, lesions in early life can impact normal visuomotor behaviors such as reaching and grasping.[9] Furthermore, the pulvinar was demonstrated to be instrumental in the preservation of vision afforded to a boy who lost his primary visual cortex bilaterally at birth[10] as well as other forms of blindsight in monkeys[11][12] and humans.[13] Strokes affecting the pulvinar have also been implicated in the development of chronic pain.[14] In a case study of photophobia caused by blue light, pulvinar nuclei associated with the melanopsin containing ipRGCs visual pathway where bilaterally activated.[15]
Other animals
The pulvinar varies in importance in different animals: it is virtually nonexistent in the rat, and grouped as the lateral posterior-pulvinar complex with the lateral posterior thalamic nucleus due to its small size in cats. In humans it makes up roughly 40% of the thalamus making it the largest of its nuclei.[16] Significant research has been undertaken in the marmoset examining the role of the retinorecipient region of the inferior pulvinar (medial subdivision), which projects to visual cortical area MT, in the early development of MT and the dorsal stream, as well as following early-life lesions of the primary visual cortex (V1).[17][18][19]
Etymology
The word pulvinar (/pʌlˈvaɪnər/) in Latin broadly means an armchair lined with numerous pillows. It was first neuroanatomically named by Karl Friedrich Burdach in 1817:[20] "The cushion (pulvinar), a swelling at the posterior end of the inner edge of the upper quadrigemina like a pillow over seats", English translation[21] (original German: "Das Polster (pulvinar), eine Anschwellung am hintern Ende des inner Randes der obern Vierhügel wie ein Kissen herüber legt"[20]). In Latin pulvinus could refer to "a sofa, cushioned seat, seat of honor, easy couch; of the couch or marriage-bed ", or more specifically, "a couch made of cushions, and spread over with a splendid covering, for the gods and persons who received divine honors; a couch or cushioned seat of the gods".[22] In the religion of ancient Rome, a pulvinar was an hetoimasia or empty throne, cushioned for occupation by a deity.[23] While anatomically, neuroanatomically there was no Roman deity between its arms, there was the pineal gland, that had in the 17th century, been identified by the French philosopher René Descartes as the seat of intellect and soul, and it has been suggested this link contributed to the first naming of this part of the brain by Karl Friedrich Burdach.[21]
References
↑ Baud, RH; etal., "Latin index of TA98, Terminologia Anatomica version 1998", Federative International Programme on Anatomical Terminologies (FIPAT), International Federation of Associations of Anatomists (IFAA), hosted by the University of Fribourg (Switzerland)
1 2 Vanderah, Todd W.; Gould, Douglas J.; Nolte, John (2016). Nolte's The human brain: an introduction to its functional anatomy (7thed.). Philadelphia, PA: Elsevier. pp.408–409. ISBN978-1-4557-2859-6.
↑ Robinson, David Lee; Petersen, Steven E. (July 1985). "Responses of pulvinar neurons to real and self-induced stimulus movement". Brain Research. 338 (2): 392–394. doi:10.1016/0006-8993(85)90176-3. PMID4027606. S2CID7547426.
↑ Mundinano, IC; Chen, J; de Souza, M; Sarossy, MG; Joanisse, MF; Goodale, MA; Bourne, JA (2017). "More than blindsight: Case report of a child with extraordinary visual capacity following perinatal bilateral occipital lobe injury". Neuropsychologia. 128: 178–186. doi:10.1016/j.neuropsychologia.2017.11.017. PMID29146465. S2CID207242249.
↑ LaBerge, D. (1999). Attention pp. 44-98. In Cognitive science (Handbook of Perception and Cognition, Second Edition), Bly BM, Rumelhart DE. (edits). Academic Press ISBN978-0-12-601730-4 p. 73
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