Thalamic reticular nucleus

Last updated
Thalamic reticular nucleus
Constudthal.gif
Thalamus
Details
Part of Thalamus
Identifiers
Latin nucleus reticularis thalami
NeuroNames 365
NeuroLex ID birnlex_1721
TA98 A14.1.08.638
TA2 5704
FMA 62026
Anatomical terms of neuroanatomy

The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally. However, recent evidence from mice and fish question this statement and define it as a dorsal thalamic structure. [1] [2] It is separated from the thalamus by the external medullary lamina. Reticular cells are GABAergic, and have discoid dendritic arbors in the plane of the nucleus.

Contents

Thalamic Reticular Nucleus is variously abbreviated TRN, RTN, NRT, and RT.

Input and output

The thalamic reticular nucleus receives input from the cerebral cortex and dorsal thalamic nuclei. Most input comes from collaterals of fibers passing through the thalamic reticular nucleus. Primary thalamic reticular nucleus efferent fibers project to dorsal thalamic nuclei, but never to the cerebral cortex. This is the only thalamic nucleus that does not project to the cerebral cortex, instead it modulates the information from other nuclei in the thalamus. Its function is modulatory on signals going through thalamus (and the reticular nucleus).

The thalamic reticular nucleus receives massive projections from the external segment of the Globus Pallidus, thought to play a part in disinhibition of thalamic cells, which is essential for initiation of movement (Parent and Hazrati, 1995)

It has been suggested that the reticular nucleus receives afferent input from the reticular formation [ citation needed ] and in turn projects to the other thalamic nuclei, regulating the flow of information through these to the cortex. There is debate over the presence of distinct sectors within the nucleus that each correspond to a different sensory or cognitive modality.

For original connectivity anatomy see Jones 1975. [3]

For discussion of mapping and cross modality pathways see Crabtree 2002. [4]

Related Research Articles

Striatum Nucleus in the basal ganglia of the brain

The striatum, or corpus striatum, is a nucleus in the subcortical basal ganglia of the forebrain. The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.

Thalamus Part of the brain responsible for relaying sensory signals and the regulation of consciousness, sleep, and alertness

The thalamus is a large mass of gray matter located in the dorsal part of the diencephalon. Nerve fibers project out of the thalamus to the cerebral cortex in all directions, allowing hub-like exchanges of information. It has several functions, such as relaying of sensory signals, including motor signals to the cerebral cortex and the regulation of consciousness, sleep, and alertness.

Trigeminal nerve Cranial nerve responsible for sensory perception and motor functions of the face

The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in the face and motor functions such as biting and chewing; it is the most complex of the cranial nerves. Its name ("trigeminal" = tri-, or three, and - geminus, or twin: thrice-twinned) derives from the fact that each of the two nerves (one on each side of the pons) has three major branches: the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3). The ophthalmic and maxillary nerves are purely sensory, whereas the mandibular nerve supplies motor as well as sensory (or "cutaneous") functions. Adding to the complexity of this nerve is the fact that autonomic nerve fibers as well as special sensory fibers (taste) are contained within it.

Lateral geniculate nucleus Relay center in thalamus

The lateral geniculate nucleus is a relay center in the thalamus for the visual pathway. It is a small, ovoid, ventral projection of the thalamus where the thalamus connects with the optic nerve. There are two LGNs, one on the left and another on the right side of the thalamus. In humans, both LGNs have six layers of neurons alternating with optic fibers.

Pulvinar nuclei

The pulvinar nuclei or nuclei of the pulvinar are the nuclei located in the thalamus. As a group they make up the collection called the pulvinar of the thalamus, usually just called the pulvinar.

Reticular formation Spinal trigeminal nucleus

The reticular formation is a set of interconnected nuclei that are located throughout the brainstem. It is not anatomically well defined, because it includes neurons located in different parts of the brain. The neurons of the reticular formation make up a complex set of networks in the core of the brainstem that extend from the upper part of the midbrain to the lower part of the medulla oblongata. The reticular formation includes ascending pathways to the cortex in the ascending reticular activating system (ARAS) and descending pathways to the spinal cord via the reticulospinal tracts.

Thalamocortical radiations

Thalamocortical radiations are the fibers between the thalamus and the cerebral cortex.

Stria terminalis Band of fibres along the thalamus

The stria terminalis is a structure in the brain consisting of a band of fibers running along the lateral margin of the ventricular surface of the thalamus. Serving as a major output pathway of the amygdala, the stria terminalis runs from its centromedial division to the ventromedial nucleus of the hypothalamus.

Head direction (HD) cells are neurons found in a number of brain regions that increase their firing rates above baseline levels only when the animal's head points in a specific direction. They have been reported in rats, monkeys, mice, chinchillas and bats, but are thought to be common to all mammals, perhaps all vertebrates and perhaps even some invertebrates, and to underlie the "sense of direction". When the animal's head is facing in the cell's "preferred firing direction" these neurons fire at a steady rate, but firing decreases back to baseline rates as the animal's head turns away from the preferred direction.

The zona incerta (ZI) is a horizontally elongated region of gray matter in the subthalamus below the thalamus. Its connections project extensively over the brain from the cerebral cortex down into the spinal cord.

Primate basal ganglia

The basal ganglia form a major brain system in all species of vertebrates, but in primates there are special features that justify a separate consideration. As in other vertebrates, the primate basal ganglia can be divided into striatal, pallidal, nigral, and subthalamic components. In primates, however, there are two pallidal subdivisions called the external globus pallidus (GPe) and internal globus pallidus (GPi). Also in primates, the dorsal striatum is divided by a large tract called the internal capsule into two masses named the caudate nucleus and the putamen—in most other species no such division exists, and only the striatum as a whole is recognized. Beyond this, there is a complex circuitry of connections between the striatum and cortex that is specific to primates. This complexity reflects the difference in functioning of different cortical areas in the primate brain.

The isothalamus is a division used by some researchers in describing the thalamus.

Anterior nuclei of thalamus

The anterior nuclei of thalamus are a collection of nuclei at the rostral end of the dorsal thalamus. They comprise the anteromedial, anterodorsal, and anteroventral nuclei.

Recurrent thalamo-cortical resonance is an observed phenomenon of oscillatory neural activity between the thalamus and various cortical regions of the brain. It is proposed by Rodolfo Llinas and others as a theory for the integration of sensory information into the whole of perception in the brain. Thalamocortical oscillation is proposed to be a mechanism of synchronization between different cortical regions of the brain, a process known as temporal binding. This is possible through the existence of thalamocortical networks, groupings of thalamic and cortical cells that exhibit oscillatory properties.

The cerebellothalamic tract or the tractus cerebellothalamicus, is part of the superior cerebellar peduncle. It originates in the cerebellar nuclei, crosses completely in the decussation of the superior cerebellar peduncle, bypasses the red nucleus, and terminates in posterior division of ventral lateral nucleus of thalamus. The ventrolateral nucleus has different divisions and distinct connections, mostly with frontal and parietal lobes. The primary motor cortex and premotor cortex get information from the ventrolateral nucleus projections originating in the interposed nucleus and dentate nuclei. Other dentate nucleus projections via thalamic pathway transmit information to prefrontal cortex and posterior parietal cortex. The cerebellum sends thalamocortical projections and in addition may also send connections from the thalamus to association areas serving cognitive and affective functions.

Anatomy of the cerebellum Structures in the cerebellum, a part of the brain

The anatomy of the cerebellum can be viewed at three levels. At the level of gross anatomy, the cerebellum consists of a tightly folded and crumpled layer of cortex, with white matter underneath, several deep nuclei embedded in the white matter, and a fluid-filled ventricle in the middle. At the intermediate level, the cerebellum and its auxiliary structures can be broken down into several hundred or thousand independently functioning modules or compartments known as microzones. At the microscopic level, each module consists of the same small set of neuronal elements, laid out with a highly stereotyped geometry.

Granule cell Type of neuron with a very small cell body

The name granule cell has been used for a number of different types of neuron whose only common feature is that they all have very small cell bodies. Granule cells are found within the granular layer of the cerebellum, the dentate gyrus of the hippocampus, the superficial layer of the dorsal cochlear nucleus, the olfactory bulb, and the cerebral cortex.

The parabrachial nuclei, also known as the parabrachial complex, are a group of nuclei in the dorsolateral pons that surrounds the superior cerebellar peduncle as it enters the brainstem from the cerebellum. They are named from the Latin term for the superior cerebellar peduncle, the brachium conjunctivum. In the human brain, the expansion of the superior cerebellar peduncle expands the parabrachial nuclei, which form a thin strip of grey matter over most of the peduncle. The parabrachial nuclei are typically divided along the lines suggested by Baxter and Olszewski in humans, into a medial parabrachial nucleus and lateral parabrachial nucleus. These have in turn been subdivided into a dozen subnuclei: the superior, dorsal, ventral, internal, external and extreme lateral subnuclei; the lateral crescent and subparabrachial nucleus along the ventrolateral margin of the lateral parabrachial complex; and the medial and external medial subnuclei

Medial pulvinar nucleus

Medial pulvinar nucleus is one of four traditionally anatomically distinguished nuclei of the pulvinar of the thalamus. The other three nuclei of the pulvinar are called lateral, inferior and anterior pulvinar nuclei.

The dorsal tegmental nucleus (DTN), also known as dorsal tegmental nucleus of Gudden (DTg), is a group of neurons located in the brain stem, which are involved in spatial navigation and orientation.

References

  1. Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A (November 2009). "Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus". Proc. Natl. Acad. Sci. USA. 106 (47): 19895–900. doi:10.1073/pnas.0910894106. PMC   2775703 . PMID   19903880.
  2. Vue TY, Bluske K, Alishahi A, et al. (April 2009). "Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice". J. Neurosci. 29 (14): 4484–97. doi:10.1523/JNEUROSCI.0656-09.2009. PMC   2718849 . PMID   19357274.
  3. Jones E (1975). "Some aspects of the organization of the thalamic reticular complex". J. Comp. Neurol. 162 (3): 285–308. doi:10.1002/cne.901620302. PMID   1150923.
  4. Crabtree JW, Isaac JT (October 2002). "New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus". J. Neurosci. 22 (19): 8754–61. doi:10.1523/JNEUROSCI.22-19-08754.2002. PMC   6757787 . PMID   12351751.

Further reading