Tuber cinereum | |
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![]() Base of brain (Tuber cinerum visible at center). | |
Details | |
Identifiers | |
Latin | tuber cinereum |
MeSH | D014371 |
NeuroNames | 1782 |
NeuroLex ID | birnlex_1189 |
TA98 | A14.1.08.408 |
TA2 | 5673 |
FMA | 62327 |
Anatomical terms of neuroanatomy |
The tuber cinereum is the portion of hypothalamus [1] forming the floor of the third ventricle situated between the optic chiasm, and the mammillary bodies. [2] The tuberal region is one of the three regions of the hypothalamus, the other two being the chiasmatic region and the mamillary region. [1]
The tuber cinereum is a convex mass of grey matter, [3] : 495 a ventral/inferior distention of the hypothalamus forming the floor of the third ventricle.[ citation needed ] The portion of the tuber cinerum at the base of the infundibulum (pituitary stalk) is the median eminence; [2] the infundibulum extends ventrally/inferiorly from the median eminence to become continuous with the infundibulum. [3] : 499
The arcuate nucleus is a part of the tuber cinereum. [3] : 497.e1 The lateral portions of tuber cinereum lodge the lateral tuberal nucleus, and tuberomammillary nucleus. The basolateral aspect of the tuber cinereum often presents slight elevations produced by the underlying lateral tuberal nucleus - the lateral eminence. [1]
The tuber cinereum is situated caudal to the optic chiasm, medial to the optic tract (which flanks it on either side), and rostral to the two mammillary bodies. [4] is continuous anteriorly with the lamina terminalis, and laterally with the anterior perforated substances.[ citation needed ]
Arterial blood supply to the tuber cinereum is provided by the anterior choroidal artery. [3] : 1464.e62
Capillaries of the tuber cinereum are specialized and confluent to enable rapid communication via brain- or blood-borne factors between compartments of the tuber, a capillary system described as the hypophyseal portal system. The subregion of the hypothalamic arcuate nucleus closest to the median eminence contains specialized permeable capillaries surrounded by wide pericapillary spaces, enabling moment-to-moment sensing of circulating blood. [5] [ non-primary source needed ]
The hypothalamus is a small part of the brain that contains a number of nuclei with a variety of functions. One of the most important functions is to link the nervous system to the endocrine system via the pituitary gland. The hypothalamus is located below the thalamus and is part of the limbic system. It forms the ventral part of the diencephalon. All vertebrate brains contain a hypothalamus. In humans, it is the size of an almond.
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum. It is a cone-shaped neuronal mass responsible for autonomic (involuntary) functions, ranging from vomiting to sneezing. The medulla contains the cardiac, respiratory, vomiting and vasomotor centers, and therefore deals with the autonomic functions of breathing, heart rate and blood pressure as well as the sleep–wake cycle. "Medulla" is from Latin, ‘pith or marrow’. And "oblongata" is from Latin, ‘lengthened or longish or elongated'.
Articles related to anatomy include:
The third ventricle is one of the four connected ventricles of the ventricular system within the mammalian brain. It is a slit-like cavity formed in the diencephalon between the two thalami, in the midline between the right and left lateral ventricles, and is filled with cerebrospinal fluid (CSF).
The midbrain or mesencephalon is the rostral-most portion of the brainstem connecting the diencephalon and cerebrum with the pons. It consists of the cerebral peduncles, tegmentum, and tectum.
The paraventricular nucleus is a nucleus in the hypothalamus. Anatomically, it is adjacent to the third ventricle and many of its neurons project to the posterior pituitary. These projecting neurons secrete oxytocin and a smaller amount of vasopressin, otherwise the nucleus also secretes corticotropin-releasing hormone (CRH) and thyrotropin-releasing hormone (TRH). CRH and TRH are secreted into the hypophyseal portal system and act on different targets neurons in the anterior pituitary. PVN is thought to mediate many diverse functions through these different hormones, including osmoregulation, appetite, and the response of the body to stress.
The tuberoinfundibular pathway refers to a population of dopamine neurons that project from the arcuate nucleus in the tuberal region of the hypothalamus to the median eminence. It is one of the four major dopamine pathways in the brain. Dopamine released at this site inhibits the secretion of prolactin from anterior pituitary gland lactotrophs by binding to D2 receptors.
The arcuate nucleus of the hypothalamus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important and diverse populations of neurons that help mediate different neuroendocrine and physiological functions, including neuroendocrine neurons, centrally projecting neurons, and astrocytes. The populations of neurons found in the arcuate nucleus are based on the hormones they secrete or interact with and are responsible for hypothalamic function, such as regulating hormones released from the pituitary gland or secreting their own hormones. Neurons in this region are also responsible for integrating information and providing inputs to other nuclei in the hypothalamus or inputs to areas outside this region of the brain. These neurons, generated from the ventral part of the periventricular epithelium during embryonic development, locate dorsally in the hypothalamus, becoming part of the ventromedial hypothalamic region. The function of the arcuate nucleus relies on its diversity of neurons, but its central role is involved in homeostasis. The arcuate nucleus provides many physiological roles involved in feeding, metabolism, fertility, and cardiovascular regulation.
The fourth ventricle is one of the four connected fluid-filled cavities within the human brain. These cavities, known collectively as the ventricular system, consist of the left and right lateral ventricles, the third ventricle, and the fourth ventricle. The fourth ventricle extends from the cerebral aqueduct to the obex, and is filled with cerebrospinal fluid (CSF).
The median eminence is generally defined as the portion of the ventral hypothalamus from which the portal vessels arise. The median eminence is a small swelling on the tuber cinereum, posterior to and atop the pituitary stalk; it lies in the area roughly bounded on its posterolateral region by the cerebral peduncles, and on its anterolateral region by the optic chiasm.
The subfornical organ (SFO) is one of the circumventricular organs of the brain. Its name comes from its location on the ventral surface of the fornix near the interventricular foramina, which interconnect the lateral ventricles and the third ventricle. Like all circumventricular organs, the subfornical organ is well-vascularized, and like all circumventricular organs except the subcommissural organ, some SFO capillaries have fenestrations, which increase capillary permeability. The SFO is considered a sensory circumventricular organ because it is responsive to a wide variety of hormones and neurotransmitters, as opposed to secretory circumventricular organs, which are specialized in the release of certain substances.
The subarachnoid cisterns are spaces formed by openings in the subarachnoid space, an anatomic space in the meninges of the brain. The space is situated between the two meninges, the arachnoid mater and the pia mater. These cisterns are filled with cerebrospinal fluid (CSF).
The anterior choroidal artery is a bilaterally paired artery of the brain. It is typically a branch of the internal carotid artery which supplies the choroid plexus of lateral ventricle and third ventricle as well as numerous structures of the brain.
The vascular organ of lamina terminalis (VOLT) (also known as organum vasculosum of the lamina terminalis(OVLT), or supraoptic crest) Is a ependymal chemosensory organ of the third ventricle situated beneath the lamina terminalis. It overlies the paraventricular nucleus of hypothalamus. The VOLT monitors the presence of peptides and macromolecules in the bloodstream, and conveys the information to the hypothalamus.
Circumventricular organs (CVOs) are structures in the brain characterized by their extensive and highly permeable capillaries, unlike those in the rest of the brain where there exists a blood–brain barrier (BBB) at the capillary level. Although the term "circumventricular organs" was originally proposed in 1958 by Austrian anatomist Helmut O. Hofer concerning structures around the brain ventricular system, the penetration of blood-borne dyes into small specific CVO regions was discovered in the early 20th century. The permeable CVOs enabling rapid neurohumoral exchange include the subfornical organ (SFO), the area postrema (AP), the vascular organ of lamina terminalis, the median eminence, the pituitary neural lobe, and the pineal gland.
The hypophyseal portal system is a system of blood vessels in the microcirculation at the base of the brain, connecting the hypothalamus with the anterior pituitary. Its main function is to quickly transport and exchange hormones between the hypothalamus arcuate nucleus and anterior pituitary gland. The capillaries in the portal system are fenestrated which allows a rapid exchange between the hypothalamus and the pituitary. The main hormones transported by the system include gonadotropin-releasing hormone, corticotropin-releasing hormone, growth hormone–releasing hormone, and thyrotropin-releasing hormone.
The interpeduncular fossa is a deep depression of the ventral surface of the midbrain between the two crura cerebri.
The interpeduncular cistern is the subarachnoid cistern situated between the dorsum sellae (anteriorly) and the two cerebral peduncles of the mesencephalon (midbrain). Its roof is represented by the floor of the third ventricle. Its floor is formed by the arachnoid membrane extending between the temporal lobes of either side. Anteriorly, it extends to the optic chiasm.
The tuberomammillary nucleus (TMN) is a histaminergic nucleus located within the posterior third of the hypothalamus. It is part of the tuber cinereum. It largely consists of histaminergic neurons. It is involved with the control of arousal, learning, memory, sleep and energy balance.
This article incorporates text in the public domain from page 813 of the 20th edition of Gray's Anatomy (1918)
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