UDP-N-acetylglucosamine kinase

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UDP-N-acetylglucosamine kinase
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EC no. 2.7.1.176
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UDP-N-acetylglucosamine kinase (EC 2.7.1.176, UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase) is an enzyme with systematic name ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase. [1] [2] This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetyl-alpha-D-glucosamine ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate

The phosphorylation of UDP-N-acetyl-D-glucosamine causes the inhibition of enzyme EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

These enzymes are found as part of plasmid-encoded [3] and chromosomal [4] bacterial toxin-antitoxin systems.

Related Research Articles

<span class="mw-page-title-main">UDP-N-acetylmuramate dehydrogenase</span> Class of enzymes

In enzymology, an UDP-N-acetylmuramate dehydrogenase (EC 1.3.1.98) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Phosphoacetylglucosamine mutase</span>

In enzymology, a phosphoacetylglucosamine mutase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine 2-epimerase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 2-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucosamine-1-phosphate N-acetyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase is an enzyme that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria:

In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acetylglucosamine kinase</span>

In enzymology, a N-acetylglucosamine kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-N-acetylglucosamine—lysosomal-enzyme N-acetylglucosaminephosphotransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-galactose—UDP-N-acetylglucosamine galactose phosphotransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine diphosphorylase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine diphosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">GNE (gene)</span> Protein-coding gene in humans

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is an enzyme that in humans is encoded by the GNE gene.

<span class="mw-page-title-main">Zeta toxin protein domain</span>

In molecular biology, the protein domain Zeta (ζ) toxin refers to a protein domain found in prokaryotes, which acts as a UDP-N-acetylglucosamine kinase. Its function is to inhibit cell wall biosynthesis and it may act as a bactericide in nature. It is also thought that Zeta toxin induces reversible protective dormancy and permeation to propidium iodide (PI).

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

N-acetylhexosamine 1-kinase is an enzyme with systematic name ATP:N-acetyl-D-hexosamine 1-phosphotransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-alpha-D-glucosaminephosphotransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetylglucosamine---decaprenyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:trans,octacis-decaprenyl-phosphate N-acetylglucosaminephosphotransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase, GNE (gene), siaA (gene), neuC (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine hydrolase (2-epimerising). This enzyme catalyses the following chemical reaction

References

  1. ↑ Mutschler H, Gebhardt M, Shoeman RL, Meinhart A (March 2011). "A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis". PLOS Biology. 9 (3): e1001033. doi:10.1371/journal.pbio.1001033. PMC   3062530 . PMID   21445328.
  2. ↑ Rocker A, Meinhart A (August 2015). "A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity". Molecular Microbiology. 97 (3): 589–604. doi: 10.1111/mmi.13051 . PMID   25943309.
  3. ↑ Zielenkiewicz U, Ceglowski P (September 2005). "The toxin-antitoxin system of the streptococcal plasmid pSM19035". Journal of Bacteriology. 187 (17): 6094–105. doi:10.1128/JB.187.17.6094-6105.2005. PMC   1196172 . PMID   16109951.
  4. ↑ Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A (July 2007). "Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae". The Journal of Biological Chemistry. 282 (27): 19606–18. doi: 10.1074/jbc.m701703200 . hdl: 11858/00-001M-0000-002C-A8AD-E . PMID   17488720.
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