ADK (gene)

ADK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BX4, 2I6A, 2I6B, 4O1L
Identifiers
Aliases	ADK , Adk, 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak, adenosine kinase
External IDs	OMIM: 102750 MGI: 87930 HomoloGene: 4891 GeneCards: ADK
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.2|10q11-q24 Start 74,151,202 bp [1] End 74,709,963 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 21,102,642 bp [2] End 21,498,637 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver Achilles tendon cavity of mouth gums islet of Langerhans right ventricle epithelium of esophagus skin of abdomen body of tongue Top expressed in left lobe of liver intercostal muscle myocardium of ventricle left lung lobe gallbladder pontine nuclei right lung lobe digastric muscle soleus muscle dorsal tegmental nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding metal ion binding kinase activity phosphotransferase activity, alcohol group as acceptor ATP binding adenosine kinase activity carbohydrate kinase activity RNA binding Cellular component nucleoplasm nucleus cytoplasm cytosol Biological process purine ribonucleoside salvage phosphorylation purine-containing compound salvage ribonucleoside monophosphate biosynthetic process AMP salvage dATP biosynthetic process adenosine salvage carbohydrate phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 132 11534 Ensembl ENSG00000156110 ENSMUSG00000039197 UniProt P55263 P55264 RefSeq (mRNA) NM_001123 NM_001202449 NM_001202450 NM_006721 NM_001369123 NM_001369124 NM_001243041 NM_134079 RefSeq (protein) NP_001114 NP_001189378 NP_001189379 NP_006712 NP_001229970 NP_598840 Location (UCSC) Chr 10: 74.15 – 74.71 Mb Chr 14: 21.1 – 21.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene. ^{[5] [6]}

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg²⁺ for activity. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000156110 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039197 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS (Mar 1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases". Proc Natl Acad Sci U S A. 93 (3): 1232–7. Bibcode:1996PNAS...93.1232S. doi: 10.1073/pnas.93.3.1232 . PMC   40062 . PMID   8577746.
6. "Entrez Gene: ADK adenosine kinase".

External links

• Human ADK genome location and ADK gene details page in the UCSC Genome Browser .

Further reading

• Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH (1976). "Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel". Cytogenet. Cell Genet. 16 (1–5): 171–4. doi:10.1159/000130582. PMID   185014.
• Singh B, Hao W, Wu Z, et al. (1996). "Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene". Eur. J. Biochem. 241 (2): 564–71. doi:10.1111/j.1432-1033.1995.tb20220.x_1. PMID   8917457.
• McNally T, Helfrich RJ, Cowart M, et al. (1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues". Biochem. Biophys. Res. Commun. 231 (3): 645–50. doi:10.1006/bbrc.1997.6157. PMID   9070863.
• Mathews II, Erion MD, Ealick SE (1998). "Structure of human adenosine kinase at 1.5 A resolution". Biochemistry. 37 (45): 15607–20. CiteSeerX   10.1.1.499.8430 . doi:10.1021/bi9815445. PMID   9843365.
• Van Rompay AR, Johansson M, Karlsson A (1999). "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein". Eur. J. Biochem. 261 (2): 509–17. doi: 10.1046/j.1432-1327.1999.00294.x . PMID   10215863.
• Singh B, Lin A, Wu ZC, Gupta RS (2001). "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons". DNA Cell Biol. 20 (1): 53–65. doi:10.1089/10445490150504693. PMID   11242543.
• Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi: 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I . PMID   12112843. S2CID   22665513.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID   12820662. S2CID   23060872.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.