CDP-archaeol synthase

Last updated
CDP-archaeol synthase
Identifiers
EC no. 2.7.7.67
CAS no. 329791-09-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

CDP-archaeol synthase (EC 2.7.7.67, CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase, CTP:2,3-GG-GP ether cytidylyltransferase, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase) is an enzyme with systematic name CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase. [1] [2] This enzyme catalyses the following chemical reaction

CTP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate diphosphate + CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol

This enzyme catalyses one of the steps in the biosynthesis of polar lipids in Archaea.

Related Research Articles

<span class="mw-page-title-main">Ether lipid</span>

In biochemistry, an ether lipid refers to any lipid in which the lipid "tail" group is attached to the glycerol backbone via an ether bond at any position. In contrast, conventional glycerophospholipids and triglycerides are triesters. Structural types include:

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an alkylglycerophosphate 2-O-acetyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a sn-glycerol-3-phosphate 1-galactosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</span> Class of enzymes

In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction:

In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a D-ribitol-5-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an ethanolamine-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucose-1-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerol-3-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

Archaeol is a diether composed of two phytanyl chains linked to the sn-2 and sn-3 positions of glycerol. As its phosphate ester, it is a common component of the membranes of archaea.

<span class="mw-page-title-main">Glycerol 1-phosphate</span> Chemical compound

sn-Glycerol 1-phosphate is the conjugate base of a phosphoric ester of glycerol. It is a component of ether lipids, which are common for archaea.

Glycerol-3-phosphate 2-O-acyltransferase is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. This enzyme catalyses the following chemical reaction

Geranylfarnesyl diphosphate synthase is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase . This enzyme catalyses the following chemical reaction

Diacylglycerol kinase (CTP dependent) (EC 2.7.1.174, DAG kinase, CTP-dependent diacylglycerol kinase, diglyceride kinase) is an enzyme with systematic name CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase. This enzyme catalyses the following chemical reaction

1L-myo-inositol 1-phosphate cytidylyltransferase is an enzyme with systematic name CTP:1L-myo-inositol 1-phosphate cytidylyltransferase. This enzyme catalyses the following chemical reaction

Pseudaminic acid cytidylyltransferase is an enzyme with systematic name CTP:5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid cytidylyltransferase. This enzyme catalyses the following chemical reaction

CDP-L-myo-inositol myo-inositolphosphotransferase is an enzyme with systematic name CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Hydroxyarchaeol</span> Chemical compound

Hydroxyarchaeol is a core lipid unique to archaea, similar to archaeol, with a hydroxide functional group at the carbon-3 position of one of its ether side chains. It is found exclusively in certain taxa of methanogenic archaea, and is a common biomarker for methanogenesis and methane-oxidation. Isotopic analysis of hydroxyarchaeol can be informative about the environment and substrates for methanogenesis.

References

  1. Morii H, Nishihara M, Koga Y (November 2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus". The Journal of Biological Chemistry. 275 (47): 36568–74. doi: 10.1074/jbc.m005925200 . PMID   10960477.
  2. Morii H, Koga Y (February 2003). "CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus". Journal of Bacteriology. 185 (4): 1181–9. doi:10.1128/jb.185.4.1181-1189.2003. PMC   142863 . PMID   12562787.