CDP-archaeol synthase

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CDP-archaeol synthase
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EC no. 2.7.7.67
CAS no. 329791-09-5
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CDP-archaeol synthase (EC 2.7.7.67, CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase, CTP:2,3-GG-GP ether cytidylyltransferase, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase) is an enzyme with systematic name CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase. [1] [2] This enzyme catalyses the following chemical reaction

CTP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate diphosphate + CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol

This enzyme catalyses one of the steps in the biosynthesis of polar lipids in Archaea.

Related Research Articles

<span class="mw-page-title-main">Ether lipid</span>

In an organic chemistry general sense, an ether lipid implies an ether bridge between an alkyl group and an unspecified alkyl or aryl group, not necessarily glycerol. If glycerol is involved, the compound is called a glyceryl ether, which may take the form of an alkylglycerol, an alkyl acyl glycerol, or in combination with a phosphatide group, a phospholipid.

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a sn-glycerol-3-phosphate 1-galactosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</span> Class of enzymes

In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction:

In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a D-ribitol-5-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an ethanolamine-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucose-1-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerol-3-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

Phosphatidate cytidylyltransferase (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from cytidine triphosphate and phosphatidate.

<span class="mw-page-title-main">Caldarchaeol</span> Chemical compound

Caldarchaeol is a membrane-spanning lipid of the glycerol dialkyl glycerol tetraether class. It is found in hyperthermophilic archaea. Membranes made up of caldarchaeol are more stable since the hydrophobic chains are linked together, allowing the microorganisms to withstand high temperatures. It is also known as dibiphytanyldiglycerol tetraether. Two glycerol units are linked together by two strains which consist of two phytanes linked together to form a linear chain of 32 carbon atoms.

Archaeol is composed of two phytanyl chains linked to the sn-2 and sn-3 positions of glycerol. As its phosphate ester, it is a common component of the membranes of archaea.

<span class="mw-page-title-main">Glycerol 1-phosphate</span> Chemical compound

sn-Glycerol 1-phosphate is the conjugate base of a phosphoric ester of glycerol. It is a component of ether lipids, which are common for archaea.

Diacylglycerol kinase (CTP dependent) (EC 2.7.1.174, DAG kinase, CTP-dependent diacylglycerol kinase, diglyceride kinase) is an enzyme with systematic name CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase. This enzyme catalyses the following chemical reaction

1L-myo-inositol 1-phosphate cytidylyltransferase is an enzyme with systematic name CTP:1L-myo-inositol 1-phosphate cytidylyltransferase. This enzyme catalyses the following chemical reaction

Pseudaminic acid cytidylyltransferase is an enzyme with systematic name CTP:5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid cytidylyltransferase. This enzyme catalyses the following chemical reaction

CDP-L-myo-inositol myo-inositolphosphotransferase is an enzyme with systematic name CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Hydroxyarchaeol</span> Chemical compound

Hydroxyarchaeol is a core lipid unique to archaea, similar to archaeol, with a hydroxide functional group at the carbon-3 position of one of its ether side chains. It is found exclusively in certain taxa of methanogenic archaea, and is a common biomarker for methanogenesis and methane-oxidation. Isotopic analysis of hydroxyarchaeol can be informative about the environment and substrates for methanogenesis.

References

  1. Morii H, Nishihara M, Koga Y (November 2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus". The Journal of Biological Chemistry. 275 (47): 36568–74. doi: 10.1074/jbc.m005925200 . PMID   10960477.
  2. Morii H, Koga Y (February 2003). "CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus". Journal of Bacteriology. 185 (4): 1181–9. doi:10.1128/jb.185.4.1181-1189.2003. PMC   142863 . PMID   12562787.