Desosaminyl transferase EryCIII

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Desosaminyl transferase EryCIII
Desosaminyl transferase EryCIII
Identifiers
EC no.	2.4.1.278
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BRENDA	BRENDA entry
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KEGG	KEGG entry
MetaCyc	metabolic pathway
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PDB structures	RCSB PDB PDBe PDBsum
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Last updated August 27, 2023

Desosaminyl transferase EryCIII (EC 2.4.1.278, EryCIII) is an enzyme with systematic name dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B

\rightleftharpoons

dTDP + erythromycin D

The enzyme is involved in erythromycin biosynthesis.

Related Research Articles

In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase is an enzyme that catalyzes the chemical reaction

In enzymology, a dTDP-4-amino-4,6-dideoxygalactose transaminase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Desosamine</span> Chemical compound

Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as the commonly prescribed erythromycin, azithromycin, clarithroymcin, methymycin, narbomycin, oleandomycin, picromycin and roxithromycin. As the name suggests, these macrolide antibiotics contain a macrolide or lactone ring and they are attached to the ring Desosamine which is crucial for bactericidal activity. The biological action of the desosamine-based macrolide antibiotics is to inhibit the bacterial ribosomal protein synthesis. These antibiotics which contain Desosamine are widely used to cure bacterial-causing infections in human respiratory system, skin, muscle tissues, and urethra.

UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335, WlbA, WbpB) is an enzyme with systematic name UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD⁺ 3-oxidoreductase. This enzyme catalyses the following chemical reaction:

Erythromycin 12 hydroxylase (EC 1.14.13.154, EryK) is an enzyme with systematic name erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating) . This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase. This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase. This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase. This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase is an enzyme with systematic name acetyl-CoA:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase. This enzyme catalyses the following chemical reaction

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase is an enzyme with systematic name acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase. This enzyme catalyses the following chemical reaction

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase is an enzyme with systematic name acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase. This enzyme catalyses the following chemical reaction

DTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase is an enzyme with systematic name acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-glucose N-acetyltransferase. This enzyme catalyses the following chemical reaction

DTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase is an enzyme with systematic name acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase. This enzyme catalyses the following chemical reaction

Glycosyltransferase DesVII is an enzyme with systematic name dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase. This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase is an enzyme with systematic name dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase is an enzyme with systematic name dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase is an enzyme with systematic name UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase is an enzyme with systematic name UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming) is an enzyme with systematic name dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase. This enzyme catalyses the following chemical reaction

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming) is an enzyme with systematic name dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase. This enzyme catalyses the following chemical reaction

References

↑ Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S (October 2005). "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". Journal of the American Chemical Society. 127 (41): 14128–9. doi:10.1021/ja053704n. PMC 2525786 . PMID 16218575.
↑ Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S (August 2004). "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". Journal of the American Chemical Society. 126 (32): 9924–5. doi:10.1021/ja048836f. PMID 15303858.
↑ Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF (January 2012). "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". Journal of Molecular Biology. 415 (1): 92–101. doi:10.1016/j.jmb.2011.10.036. PMC 3391682 . PMID 22056329.

External links

Desosaminyl+transferase+EryCIII at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[1] Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S (October 2005). "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". Journal of the American Chemical Society. 127 (41): 14128–9. doi:10.1021/ja053704n. PMC 2525786 . PMID 16218575.

[2] Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S (August 2004). "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". Journal of the American Chemical Society. 126 (32): 9924–5. doi:10.1021/ja048836f. PMID 15303858.

[3] Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF (January 2012). "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". Journal of Molecular Biology. 415 (1): 92–101. doi:10.1016/j.jmb.2011.10.036. PMC 3391682 . PMID 22056329.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)