EBI3

EBI3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 7U7N, 7Z0L, 7ZG0, 7ZXK, 8D85
Identifiers
Aliases	EBI3 , IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	OMIM: 605816; MGI: 1354171; HomoloGene: 4207; GeneCards: EBI3; OMA:EBI3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 4,229,523 bp [1] End 4,237,528 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 D|17 29.08 cM Start 56,259,640 bp [2] End 56,264,022 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta decidua spleen appendix lymph node gonad gallbladder right adrenal gland C1 segment right coronary artery Top expressed in granulocyte splanchnocranium rib hyoid bone humerus stroma of bone marrow sphenoid bone Meckel's cartilage lesser wing of sphenoid bone tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity cytokine activity interleukin-27 receptor binding protein binding ciliary neurotrophic factor receptor activity cytokine binding Cellular component extracellular region plasma membrane membrane extracellular space endoplasmic reticulum lumen external side of plasma membrane receptor complex ciliary neurotrophic factor receptor complex CNTFR-CLCF1 complex Biological process T-helper 1 type immune response T cell proliferation humoral immune response positive regulation of alpha-beta T cell proliferation regulation of signaling receptor activity interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10148 50498 Ensembl ENSG00000105246 ENSMUSG00000003206 UniProt Q14213 O35228 RefSeq (mRNA) NM_005755 NM_015766 RefSeq (protein) NP_005746 NP_056581 Location (UCSC) Chr 19: 4.23 – 4.24 Mb Chr 17: 56.26 – 56.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene. ^{[5] [6]}

Function

This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses. ^[7]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells. ^[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12. ^{[7] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000105246 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003206 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".
6. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC   189923 . PMID   8551575.
7. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID   18033300. S2CID   4425281.
8. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID   16906167. S2CID   32503719.
9. Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi: 10.1002/eji.200737810 . PMID   17874423.

Further reading

• Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2". N. Engl. J. Med. 295 (7): 397. doi:10.1056/NEJM197608122950720. PMID   934235.
• Devergne O, Hummel M, Koeppen H, et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC   189923 . PMID   8551575.
• Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041–6. Bibcode:1997PNAS...9412041D. doi: 10.1073/pnas.94.22.12041 . PMC   23696 . PMID   9342359.
• Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi: 10.1016/S1074-7613(02)00324-2 . PMID   12121660.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases". J. Pathol. 202 (2): 164–71. doi:10.1002/path.1508. PMID   14743498. S2CID   25887054.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease". J. Med. Virol. 73 (3): 432–8. doi:10.1002/jmv.20109. PMID   15170639. S2CID   40275209.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• EBI3 human gene location in the UCSC Genome Browser .
• EBI3 human gene details in the UCSC Genome Browser .