Ganglioside galactosyltransferase

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ganglioside galactosyltransferase
Identifiers
EC no. 2.4.1.62
CAS no. 37217-28-0
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MetaCyc metabolic pathway
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In enzymology, a ganglioside galactosyltransferase (EC 2.4.1.62) is an enzyme that catalyzes the chemical reaction

UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine

The 2 substrates of this enzyme are UDP-galactose and N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine, whereas its 2 products are UDP and D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase. Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl), galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.

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(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O- - -O-beta-D-galactopyranosyl- -beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction:

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl- )-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.148 with systematic name UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl- -N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

Beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase. This enzyme catalyses the following chemical reaction

Galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 6-beta-N-acetylglucosaminyltransferase. This enzyme catalyses the following chemical reaction

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, is an enzyme that catalyses the following chemical reaction:

Glucosylceramide beta-1,4-galactosyltransferase is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase. This enzyme catalyses the following chemical reaction

Lactotriaosylceramide beta-1,4-galactosyltransferase is an enzyme with systematic name UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase. This enzyme catalyses the following chemical reaction

References


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