Glucosylceramide beta-1,4-galactosyltransferase

Last updated
Glucosylceramide beta-1,4-galactosyltransferase
Identifiers
EC no. 2.4.1.274
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Involved in the synthesis of several different major classes of glycosphingolipids.

Related Research Articles

N-acetyllactosamine synthase is a galactosyltransferase enzyme. It is a component of lactose synthase This enzyme modifies the connection between two molecule UDP-galactose and N-actyl-D-glucosamine and generates two different molecules UDP and N-acetyllactosamine as products. The main function of the enzyme is associated with the biosynthesis of glycoproteins and glycolipids in both human and animals. In human, the activity of this enzyme can be found in Golgi apparatus.

<span class="mw-page-title-main">Lactose synthase</span> Enzyme that generates lactose

Lactose synthase is an enzyme that generates lactose from glucose and UDP-galactose.

In enzymology, a 2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a ganglioside galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucosaminylgalactosylglucosylceramide beta-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide 1,3-N-anning-beta-D-glrofelucosaminyltlolferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide 4-alpha-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide beta-1,3-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acetyllactosaminide 3-alpha-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acylsphingosine galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a xylosylprotein 4-beta-galactosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">B4GALT7</span> Protein-coding gene in the species Homo sapiens

Beta-1,4-galactosyltransferase 7 also known as galactosyltransferase I is an enzyme that in humans is encoded by the B4GALT7 gene. Galactosyltransferase I catalyzes the synthesis of the glycosaminoglycan-protein linkage in proteoglycans. Proteoglycans in turn are structural components of the extracellular matrix that is found between cells in connective tissues.

<span class="mw-page-title-main">UGT8</span> Protein-coding gene in the species Homo sapiens

2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that in humans is encoded by the UGT8 gene.

<span class="mw-page-title-main">Lactosylceramide</span>

The Lactosylceramides, also known as LacCer, are a class of glycosphingolipids composed of a variable hydrophobic ceramide lipid and a hydrophilic sugar moiety. Lactosylceramides are found in microdomains on the plasma layers of numerous cells. Moreover, they are a type of ceramide including lactose, which is an example of a globoside.

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O- - -O-beta-D-galactopyranosyl- -beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction:

Beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase. This enzyme catalyses the following chemical reaction

Galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 6-beta-N-acetylglucosaminyltransferase. This enzyme catalyses the following chemical reaction

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, is an enzyme that catalyses the following chemical reaction:

Lactotriaosylceramide beta-1,4-galactosyltransferase is an enzyme with systematic name UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Chatterjee S, Castiglione E (January 1987). "UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochimica et Biophysica Acta. 923 (1): 136–42. doi:10.1016/0304-4165(87)90136-X. PMID   3099851.
  2. ↑ Trinchera M, Fiorilli A, Ghidoni R (March 1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase". Biochemistry. 30 (10): 2719–24. doi:10.1021/bi00224a021. PMID   1900430.
  3. ↑ Chatterjee S, Ghosh N, Khurana S (April 1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney". The Journal of Biological Chemistry. 267 (10): 7148–53. doi: 10.1016/S0021-9258(19)50550-6 . PMID   1551920.
  4. ↑ Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N (May 1998). "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain". The Journal of Biological Chemistry. 273 (22): 13570–7. doi: 10.1074/jbc.273.22.13570 . PMID   9593693.
  5. ↑ Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N (May 1999). "cDNA cloning and expression of human lactosylceramide synthase". Biochimica et Biophysica Acta. 1438 (2): 301–4. doi:10.1016/S1388-1981(99)00051-7. PMID   10320813.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.