Lactosylceramide alpha-2,3-sialyltransferase

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lactosylceramide alpha-2,3-sialyltransferase
Identifiers
EC no. 2.4.99.9
CAS no. 125752-90-1
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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Gene Ontology AmiGO / QuickGO
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In enzymology, a lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1,4-beta-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-, and glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3-, sialyltransferase, CMP-acetylneuraminate-lactosylceramide-sialyltransferase, CMP-acetylneuraminic acid:lactosylceramide sialyltransferase, CMP-sialic acid:lactosylceramide-sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide, sialyltransferase, ganglioside GM3 synthetase, GM3 synthase, GM3 synthetase, and SAT 1. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2EX0 and 2EX1.

Related Research Articles

In enzymology, a CMP-N-acetylneuraminate monooxygenase (EC 1.14.18.2) is an enzyme that catalyzes the chemical reaction

In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an alpha-N-acetylneuraminate alpha-2,8-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a beta-galactoside alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a beta-galactoside alpha-2,6-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a ganglioside galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide 1,3-N-anning-beta-D-glrofelucosaminyltlolferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide 4-alpha-galactosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide alpha-2,6-N-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a monosialoganglioside sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acetyllactosaminide 3-alpha-galactosyltransferase is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">ST3GAL4</span> Protein-coding gene in the species Homo sapiens

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

<span class="mw-page-title-main">Lactosylceramide</span>

The Lactosylceramides, also known as LacCer, are a class of glycosphingolipids composed of a variable hydrophobic ceramide lipid and a hydrophilic sugar moiety. Lactosylceramides are found in microdomains on the plasma layers of numerous cells. Moreover, they are a type of ceramide including lactose, which is an example of a globoside.

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O- - -O-beta-D-galactopyranosyl- -beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction:

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, is an enzyme that catalyses the following chemical reaction:

α-N-Acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-α-sialyltransferase is an enzyme with systematic name CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase. This enzyme catalyses the following chemical reaction

References


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