Myeloblastin

Myeloblastin
Identifiers
EC no.	3.4.21.76
CAS no.	128028-50-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Myeloblastin (EC 3.4.21.76, leukocyte proteinase 3, leukocyte proteinase 4, proteinase PR-3, proteinase-3 , PMNL proteinase) is an enzyme. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val-

This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation. ^[4]

See also

• Proteinase 3

References

1. Martin KR, Witko-Sarsat V (September 2017). "Proteinase 3: the odd one out that became an autoantigen". Journal of Leukocyte Biology. 102 (3): 689–698. doi: 10.1189/jlb.3MR0217-069R . PMID   28546501.
2. Brubaker MJ, Groutas WC, Hoidal JR, Rao NV (November 1992). "Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters". Biochemical and Biophysical Research Communications. 188 (3): 1318–24. Bibcode:1992BBRC..188.1318B. doi:10.1016/0006-291x(92)91375-z. PMID   1445363.
3. Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC (February 1992). "Substrate and inhibitor studies on proteinase 3". FEBS Letters. 297 (1–2): 119–23. Bibcode:1992FEBSL.297..119K. doi: 10.1016/0014-5793(92)80340-m . PMID   1551417.
4. Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE (December 1989). "Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells". Cell. 59 (6): 959–68. doi: 10.1016/0092-8674(89)90752-6 . PMID   2598267.

External links

• Myeloblastin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)