O-phosphoseryl-tRNASec kinase

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O-phosphoseryl-tRNASec kinase
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EC no. 2.7.1.164
CAS no. 91273-83-5
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O-phosphoseryl-tRNASec kinase (EC 2.7.1.164, PSTK, phosphoseryl-tRNA[Ser]Sec kinase, phosphoseryl-tRNASec kinase) is an enzyme with systematic name ATP:L-seryl-tRNASec O-phosphotransferase. [1] [2] [3] This enzyme catalyses the following chemical reaction

ATP + L-seryl-tRNASec ADP + O-phospho-L-seryl-tRNASec

In archaea and eukarya selenocysteine formation is achieved by a two-step process.

Related Research Articles

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<span class="mw-page-title-main">Selenocysteine</span> Chemical compound

Selenocysteine is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur.

<span class="mw-page-title-main">Adenosine monophosphate</span> Chemical compound

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. It is an ester of phosphoric acid and the nucleoside adenosine. As a substituent it takes the form of the prefix adenylyl-.

<span class="mw-page-title-main">SECIS element</span> RNA sequence directing the translation of UGA codons as selenocysteines

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<span class="mw-page-title-main">Serine/threonine-specific protein kinase</span> Class of protein kinase enzymes

A serine/threonine protein kinase is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid residues serine or threonine, which have similar side chains. At least 350 of the 500+ human protein kinases are serine/threonine kinases (STK).

<span class="mw-page-title-main">Diphosphomevalonate decarboxylase</span> InterPro Family

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase, is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">Histidine kinase</span>

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<span class="mw-page-title-main">SEP15</span> Protein-coding gene in the species Homo sapiens

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<i>SARS</i> (gene) Protein-coding gene in the species Homo sapiens

SARS and cytoplasmic seryl-tRNA synthetase are a human gene and its encoded enzyme product, respectively. SARS belongs to the class II amino-acyl tRNA family and is found in all humans; its encoded enzyme, seryl-tRNA synthetase, is involved in protein translation and is related to several bacterial and yeast counterparts.

<span class="mw-page-title-main">SEPX1</span> Protein-coding gene in the species Homo sapiens

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

<span class="mw-page-title-main">SEPSECS</span> Protein-coding gene in the species Homo sapiens

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.

<span class="mw-page-title-main">SARS2</span> Protein-coding gene in the species Homo sapiens

Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene.

Formate dehydrogenase (acceptor) (EC 1.1.99.33, FDHH, FDH-H, FDH-O, formate dehydrogenase H, formate dehydrogenase O) is an enzyme with systematic name formate:acceptor oxidoreductase. This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNA:Cys-tRNA synthase is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase. This enzyme catalyses the following chemical reaction

Propionate kinase is an enzyme with systematic name ATP:propanoate phosphotransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase</span>

O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase is an enzyme with systematic name selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase. This enzyme catalyses the following chemical reaction

O-phospho-L-serine—tRNA ligase is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming). This enzyme catalyses the following chemical reaction:

References

  1. Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL (August 2004). "Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase". Proceedings of the National Academy of Sciences of the United States of America. 101 (35): 12848–53. doi: 10.1073/pnas.0402636101 . PMC   516484 . PMID   15317934.
  2. Sherrer RL, O'Donoghue P, Söll D (March 2008). "Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation". Nucleic Acids Research. 36 (4): 1247–59. doi:10.1093/nar/gkm1134. PMC   2275090 . PMID   18174226.
  3. Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC (March 1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37 (10): 3518–28. doi:10.1021/bi972177k. PMID   9521673.