PI4KA

PI4KA
Identifiers
Aliases	PI4KA , PI4K-ALPHA, PIK4CA, pi4K230, PMGYCHA, phosphatidylinositol 4-kinase alpha, SPG84, GIDID2
External IDs	OMIM: 600286; MGI: 2448506; HomoloGene: 11171; GeneCards: PI4KA; OMA:PI4KA - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21 Start 20,707,691 bp [1] End 20,859,417 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 17,098,215 bp [2] End 17,224,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus right frontal lobe Brodmann area 9 right hemisphere of cerebellum primary visual cortex prefrontal cortex anterior cingulate cortex nucleus accumbens pituitary gland putamen Top expressed in substantia nigra superior frontal gyrus primary motor cortex prefrontal cortex subiculum medial dorsal nucleus medial geniculate nucleus medial vestibular nucleus dorsal striatum neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding 1-phosphatidylinositol 4-kinase activity kinase activity cadherin binding Cellular component cytoplasm Golgi-associated vesicle membrane cytosol extracellular exosome membrane focal adhesion plasma membrane Biological process phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process signal transduction viral RNA genome replication phosphorylation actin cytoskeleton organization phosphatidylinositol-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5297 224020 Ensembl ENSG00000241973 ENSMUSG00000041720 UniProt P42356 E9Q3L2 RefSeq (mRNA) NM_002650 NM_058004 NM_001362862 NM_001362863 NM_001001983 NM_001373955 RefSeq (protein) NP_477352 NP_001349791 NP_001349792 NP_001001983 Location (UCSC) Chr 22: 20.71 – 20.86 Mb Chr 16: 17.1 – 17.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene. ^{[5] [6] [7]}

Function

This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene. ^[7]

Clinical significance

The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV). ^[8] Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000241973 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041720 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wong K, Cantley LC (Dec 1994). "Cloning and characterization of a human phosphatidylinositol 4-kinase". J Biol Chem. 269 (46): 28878–84. doi: 10.1016/S0021-9258(19)61989-7 . PMID   7961848.
6. Nakagawa T, Goto K, Kondo H (Aug 1996). "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase". J Biol Chem. 271 (20): 12088–94. doi: 10.1074/jbc.271.20.12088 . PMID   8662589.
7. "Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide".
8. Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R (January 2011). "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe. 9 (1): 32–45. doi:10.1016/j.chom.2010.12.002. PMC   3433060 . PMID   21238945.
9. Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V (May 2013). "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLOS Pathog. 9 (5) e1003359. doi: 10.1371/journal.ppat.1003359 . PMC   3649985 . PMID   23675303.

Further reading

• Gehrmann T, Heilmeyer LM (1998). "Phosphatidylinositol 4-kinases". Eur. J. Biochem. 253 (2): 357–70. doi:10.1046/j.1432-1327.1998.2530357.x. PMID   9654085.
• Graziani A, Ling LE, Endemann G, et al. (1992). "Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes". Biochem. J. 284 (Pt 1): 39–45. doi:10.1042/bj2840039. PMC   1132694 . PMID   1318025.
• Kauffmann-Zeh A, Thomas GM, Ball A, et al. (1995). "Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling". Science. 268 (5214): 1188–90. Bibcode:1995Sci...268.1188K. doi:10.1126/science.7761838. PMID   7761838.
• Prasad KV, Kapeller R, Janssen O, et al. (1994). "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". Mol. Cell. Biol. 13 (12): 7708–17. doi:10.1128/mcb.13.12.7708. PMC   364842 . PMID   8246987.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". J. Biol. Chem. 272 (46): 29174–80. doi: 10.1074/jbc.272.46.29174 . PMID   9360995.
• Gehrmann T, Gülkan H, Suer S, et al. (1999). "Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230". Biochim. Biophys. Acta. 1437 (3): 341–56. doi:10.1016/s1388-1981(99)00029-3. PMID   10101268.
• Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. doi: 10.1074/jbc.M200831200 . PMID   11907035.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. 33 (1): 46–52. doi: 10.1002/immu.200390006 . PMID   12594831. S2CID   26388891.
• Carloni V, Mazzocca A, Ravichandran KS (2004). "Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells". Oncogene. 23 (8): 1566–74. doi:10.1038/sj.onc.1207287. PMID   14676841. S2CID   10393697.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. doi: 10.5483/bmbrep.2004.37.6.741 . PMID   15607035.
• Weixel KM, Blumental-Perry A, Watkins SC, et al. (2005). "Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases". J. Biol. Chem. 280 (11): 10501–8. doi: 10.1074/jbc.M414304200 . PMID   15634669.
• Israels SJ, McMillan-Ward EM (2005). "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen". Thromb. Haemost. 93 (2): 311–8. doi:10.1160/TH04-08-0503. PMID   15711748. S2CID   36437042.
• Waugh MG, Minogue S, Chotai D, et al. (2006). "Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts". J. Biol. Chem. 281 (7): 3757–63. doi: 10.1074/jbc.M506527200 . PMID   16249177.
• Israels SJ, McMillan-Ward EM (2005). "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen". Thromb. Haemost. 93 (2): 311–8. doi:10.1160/TH04-08-0503. PMID   15711748. S2CID   36437042.
• Reiss S, et al. (2011). "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe. 9 (1): 32–45. doi:10.1016/j.chom.2010.12.002. PMC   3433060 . PMID   21238945.
• Reiss S, et al. (2013). "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLOS Pathog. 9 (5) e1003359. doi: 10.1371/journal.ppat.1003359 . PMC   3649985 . PMID   23675303.