Pestivirus NS3 polyprotein peptidase

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Pestivirus NS3 polyprotein peptidase
Identifiers
EC no. 3.4.21.113
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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NCBI proteins

Pestivirus NS3 polyprotein peptidase (EC 3.4.21.113, border disease virus NS3 endopeptidase, BDV NS3 endopeptidase, bovine viral diarrhea virus NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 endopeptidase, p80) is an enzyme. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites

The genomes of Cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80).

References

  1. ↑ Wiskerchen M, Collett MS (September 1991). "Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing". Virology. 184 (1): 341–50. doi:10.1016/0042-6822(91)90850-b. PMID   1651596.
  2. ↑ Tautz N, Elbers K, Stoll D, Meyers G, Thiel HJ (July 1997). "Serine protease of pestiviruses: determination of cleavage sites". Journal of Virology. 71 (7): 5415–22. doi:10.1128/JVI.71.7.5415-5422.1997. PMC   191781 . PMID   9188613.
  3. ↑ Xu J, Mendez E, Caron PR, Lin C, Murcko MA, Collett MS, Rice CM (July 1997). "Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication". Journal of Virology. 71 (7): 5312–22. doi:10.1128/JVI.71.7.5312-5322.1997. PMC   191768 . PMID   9188600.
  4. ↑ Tautz N, Kaiser A, Thiel HJ (August 2000). "NS3 serine protease of bovine viral diarrhea virus: characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions". Virology. 273 (2): 351–63. doi: 10.1006/viro.2000.0425 . PMID   10915606.
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