S-methyl-5'-thioinosine phosphorylase

Last updated
S-methyl-5'-thioinosine phosphorylase
Identifiers
EC no. 2.4.2.44
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

S-methyl-5'-thioinosine phosphorylase (EC 2.4.2.44, MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. [1] This enzyme catalyses the following chemical reaction

S-methyl-5'-thioinosine + phosphate hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

The catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine.

Related Research Articles

A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. The term often refers to nucleotide salvage in particular, in which nucleotides are synthesized from intermediates in their degradative pathway.

<span class="mw-page-title-main">Purine nucleoside phosphorylase</span> Enzyme

Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase is an enzyme that in humans is encoded by the NP gene. It catalyzes the chemical reaction

In enzymology, a S-methyl-5-thioribose-1-phosphate isomerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Methylthioribulose 1-phosphate dehydratase</span>

The enzyme methylthioribulose 1-phosphate dehydratase (EC .2.1.109) catalyzes the chemical reaction

The enzyme methylphosphothioglycerate phosphatase (EC 3.1.3.14) catalyzes the reaction

In enzymology, a 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, an alpha,alpha-trehalose phosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Cellobiose phosphorylase</span> Class of enzymes

In enzymology, a cellobiose phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a deoxyuridine phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a kojibiose phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a pyrimidine-nucleoside phosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">S-methyl-5'-thioadenosine phosphorylase</span> Class of enzymes

In enzymology, a S-methyl-5'-thioadenosine phosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Thymidine phosphorylase</span> Enzyme

Thymidine phosphorylase is an enzyme that is encoded by the TYMP gene and catalyzes the reaction:

In enzymology, an urate-ribonucleotide phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, an uridine phosphorylase is an enzyme that catalyzes the chemical reaction

In enzymology, a S-methyl-5-thioribose kinase is an enzyme that catalyzes the chemical reaction

Xanthosine phosphorylase, also known as inosine-guanosine phosphorylase, is a catalytic enzyme encoded by the XapA gene in E. coli. The presence of xanthosine is known to induce the synthesis of xanthosine phosphorylase by the XapA gene. The enzyme's main functions are nucleoside phosphorolysis and the synthesis of nucleotides, making it a member of the purine nucleoside phosphorylase group. This protein can degrade all purine nucleosides except adenosine, deoxyadenosine, hypoxanthine arabinoside. These degradation reactions are reversible in vitro, however, phosphorolysis dominates in vivo. Xanthosine phosphorylase is localized in the cytoplasm because these degradation functions take place there. Xanthosine phosphorylase preferentially uses the neutral form of xanthosine over its monoanionic form because it prefers to be in a neutral environment.

Beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase is an enzyme with systematic name beta-D-galactosyl-(1->4)-L-rhamnose:phosphate 1-alpha-D-galactosyltransferase. This enzyme catalyses the following chemical reaction

4-O-beta-D-mannosyl-D-glucose phosphorylase is an enzyme with systematic name 4-O-beta-D-mannopyranosyl-D-glucopyranose:phosphate alpha-D-mannosyltransferase. This enzyme catalyses the following chemical reaction

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase is an enzyme with systematic name UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Guan R, Ho MC, Almo SC, Schramm VL (February 2011). "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing". Biochemistry. 50 (7): 1247–54. doi:10.1021/bi101642d. PMC   3040260 . PMID   21197954.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.