Synergistota

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Synergistota
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Jumas-Bilak et al. 2021 [1]
Phylum: Synergistota
Jumas-Bilak et al. 2009
Class: Synergistia
Jumas-Bilak et al. 2009
Order: Synergistales
Jumas-Bilak et al. 2009
Families
  • Acetomicrobiaceae
  • Aminiphilaceae
  • Aminithiophilaceae
  • Aminobacteriaceae
  • Dethiosulfovibrionaceae
  • Synergistaceae
  • Thermosynergistaceae
  • Thermovirgaceae
Synonyms
  • "Synergistaeota" Oren et al. 2015
  • "Synergistetes" Jumas-Bilak et al. 2009
  • "Synergistota" Whitman et al. 2018

The Synergistota is a phylum of anaerobic bacteria that show Gram-negative staining and have rod/vibrioid cell shape. [2] [3] Although Synergistota have a diderm cell envelope, [4] [5] the genes for various proteins involved in lipopolysaccharides biosynthesis have not yet been detected in Synergistota, indicating that they may have an atypical outer cell envelope. [4] [5] The Synergistota inhabit a majority of anaerobic environments including animal gastrointestinal tracts, soil, oil wells, and wastewater treatment plants and they are also present in sites of human diseases such as cysts, abscesses, and areas of periodontal disease. [6] [7] Due to their presence at illness related sites, the Synergistota are suggested to be opportunistic pathogens but they can also be found in healthy individuals in the microbiome of the umbilicus and in normal vaginal flora. [7] [8] Species within this phylum have also been implicated in periodontal disease, [9] gastrointestinal infections and soft tissue infections. [7] Other species from this phylum have been identified as significant contributors in the degradation of sludge for production of biogas in anaerobic digesters and are potential candidates for use in renewable energy production through their production of hydrogen gas. [10] All of the known Synergistota species and genera are presently part of a single class (Synergistia), order (Synergistiales), and family (Synergistaceae). [3]

Contents

Comparative genomics and molecular signatures

Recent comparative analyses of sequenced Synergistota genomes have led to identification of large numbers of conserved signature indels (CSIs) in protein sequences that are specific for either all sequenced Synergistota species or some of their sub-clades that are observed in phylogenetic trees. [11] Of the CSIs that were identified, 32 in widely distributed proteins such as RpoB, RpoC, UvrD, GyrA, PolA, PolC, MraW, NadD, PyrE, RpsA, RpsH, FtsA, RadA, etc., including a large >300 aa insert in the RpoC protein, are present in various Synergistota species, but except for isolated bacteria, these CSIs are not found in the protein homologues from all other organisms. These CSIs provide novel molecular markers for distinguishing Synergistota species from all other bacteria. [11] Seven other CSIs in important proteins including a 13 aa in RpoB were found to be uniquely present in Jonquetella, Pyramidobacter and Dethiosulfovibrio species indicating a close and specific relationship among these bacteria, which is also strongly supported by phylogenetic trees. Fifteen addition CSIs that were only present in Jonquetella and Pyramidobacter indicate a close association between these two species. [11] Lastly, a close relationship between the Aminomonas and Thermanaerovibrio species is also supported by 9 identified CSIs. The identified molecular markers provide reliable means for the division of species from the phylum Synergistota into intermediate taxonomic ranks such as families and orders. [11]

Phylogeny

16S rRNA based LTP_08_2023 [12] [13] [14] 120 single copy marker proteins based GTDB 08-RS214 [15] [16] [17]
Synergistota

Thermosynergistes pyruvativorans Yang et al. 2021

Acetomicrobium

A. flavidum Soutschek et al. 1985

A. mobile(Menes & Muxi 2002) Ben Hania et al. 2016

A. hydrogeniformans (Maune & Tanner 2012) Ben Hania et al. 2016

A. thermoterrenum(Rees et al. 1997) Ben Hania et al. 2016

Thermovirga lienii Dahle and Birkeland 2006

Aminithiophilus ramosus Pradel et al. 2023

Aminiphilus circumscriptus Díaz et al. 2007

Aminomonas paucivorans Baena et al. 1999

Thermanaerovibrio

T. acidaminovorans (Guangsheng et al. 1997) Baena et al. 1999

T. velox Zavarzina et al. 2000

Synergistes jonesii Allison et al. 1993

Cloacibacillus

C. evryensis Ganesan et al. 2008

C. porcorum Looft et al. 2013

Lactivibrio alcoholicus Qiu et al. 2014

Aminivibrio pyruvatiphilus Honda et al. 2013

Fretibacterium fastidiosum Vartoukian et al. 2013

Aminobacterium

A. thunnarium Hamdi et al. 2015

A. colombiense Baena et al. 1999 (type sp.)

A. mobile Baena et al. 2000

Jonquetella anthropi Jumas-Bilak et al. 2007

Rarimicrobium hominis Jumas-Bilak et al. 2015

Pyramidobacter

P. piscolensDownes et al. 2009

P. porciWylensek et al. 2021

Dethiosulfovibrio

D. salsuginisDíaz-Cárdenas et al. 2010

D. faecalisGrabowski et al. 2022

D. peptidovorans Magot et al. 1997 (type sp.)

D. marinusSurkov et al. 2001

D. acidaminovoransSurkov et al. 2001

D. russensisSurkov et al. 2001

Synergistota
Thermosynergistaceae

Thermosynergistes pyruvativorans

Acetomicrobiaceae
Thermovirgaceae

Thermovirga lienii

Aminiphilaceae

Aminiphilus circumscriptus

Synergistaceae
"Ca.  Caccocola"

"Ca. C. faecigallinarum" Gilroy et al. 2021

"Ca. C. faecipullorum" Gilroy et al. 2021

Aminobacteriaceae
Dethiosulfovibrionaceae

Jonquetella anthropi

Pyramidobacter

P. piscolens

P. porci

Dethiosulfovibrio

D. salsuginis

D. faecalis

D. peptidovorans

D. russensis

Taxonomy

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LSPN) [18] and the National Center for Biotechnology Information (NCBI). [19]

See also

Related Research Articles

<span class="mw-page-title-main">Spirochaete</span> Phylum of bacteria

A spirochaete or spirochete is a member of the phylum Spirochaetota, which contains distinctive diderm (double-membrane) Gram-negative bacteria, most of which have long, helically coiled cells. Spirochaetes are chemoheterotrophic in nature, with lengths between 3 and 500 μm and diameters around 0.09 to at least 3 μm.

The Aquificota phylum is a diverse collection of bacteria that live in harsh environmental settings. The name Aquificota was given to this phylum based on an early genus identified within this group, Aquifex, which is able to produce water by oxidizing hydrogen. They have been found in springs, pools, and oceans. They are autotrophs, and are the primary carbon fixers in their environments. These bacteria are Gram-negative, non-spore-forming rods. They are true bacteria as opposed to the other inhabitants of extreme environments, the Archaea.

The Chloroflexia are a class of bacteria in the phylum Chloroflexota. Chloroflexia are typically filamentous, and can move about through bacterial gliding. It is named after the order Chloroflexales.

<span class="mw-page-title-main">Deinococcota</span> Phylum of Gram-negative bacteria

Deinococcota is a phylum of bacteria with a single class, Deinococci, that are highly resistant to environmental hazards, also known as extremophiles. These bacteria have thick cell walls that give them gram-positive stains, but they include a second membrane and so are closer in structure to those of gram-negative bacteria.

<span class="mw-page-title-main">Verrucomicrobiota</span> Phylum of bacteria

Verrucomicrobiota is a phylum of Gram-negative bacteria that contains only a few described species. The species identified have been isolated from fresh water, marine and soil environments and human faeces. A number of as-yet uncultivated species have been identified in association with eukaryotic hosts including extrusive explosive ectosymbionts of protists and endosymbionts of nematodes from genus Xiphinema, residing in their gametes. The verrucomicrobial bacterium Akkermansia muciniphila is a human intestinal symbiotic bacterium that is considered as a promising probiotic.

<span class="mw-page-title-main">Chlamydiota</span> Phylum of bacteria

The Chlamydiota are a bacterial phylum and class whose members are remarkably diverse, including pathogens of humans and animals, symbionts of ubiquitous protozoa, and marine sediment forms not yet well understood. All of the Chlamydiota that humans have known about for many decades are obligate intracellular bacteria; in 2020 many additional Chlamydiota were discovered in ocean-floor environments, and it is not yet known whether they all have hosts. Historically it was believed that all Chlamydiota had a peptidoglycan-free cell wall, but studies in the 2010s demonstrated a detectable presence of peptidoglycan, as well as other important proteins.

The Thermotogota are a phylum of the domain Bacteria. The phylum contains a single class, Thermotogae. The phylum Thermotogota is composed of Gram-negative staining, anaerobic, and mostly thermophilic and hyperthermophilic bacteria.

Fibrobacterota is a small bacterial phylum which includes many of the major rumen bacteria, allowing for the degradation of plant-based cellulose in ruminant animals. Members of this phylum were categorized in other phyla. The genus Fibrobacter was removed from the genus Bacteroides in 1988.

The Gemmatimonadota are a phylum of bacteria established in 2003. The phylum contains two classes Gemmatimonadetes and Longimicrobia.

Chloracidobacterium is a genus of the Acidobacteriota. It is currently assigned to the family Acidobacteriaceae, but phylogenetic evidence suggests that it belongs in Blastocatellia.

The Chloroflexota are a phylum of bacteria containing isolates with a diversity of phenotypes, including members that are aerobic thermophiles, which use oxygen and grow well in high temperatures; anoxygenic phototrophs, which use light for photosynthesis ; and anaerobic halorespirers, which uses halogenated organics as electron acceptors.

The Veillonellaceae are a family of the Clostridia, formerly known as Acidaminococcaceae. Bacteria in this family are grouped together mainly based on genetic studies, which place them among the Bacillota. Supporting this placement, several species are capable of forming endospores. However, they differ from most other Bacillota in having Gram-negative stains. The cell wall composition is peculiar.

<i>Deinococcus</i> Genus of bacteria

Deinococcus is in the monotypic family Deinococcaceae, and one genus of three in the order Deinococcales of the bacterial phylum Deinococcota highly resistant to environmental hazards. These bacteria have thick cell walls that give them Gram-positive stains, but they also include a second membrane and are therefore closer in structure to Gram-negative bacteria. Deinococcus survive when their DNA is exposed to high doses of gamma and UV radiation. Whereas other bacteria change their structure in the presence of radiation, such as by forming endospores, Deinococcus tolerate it without changing their cellular form and do not retreat into a hardened structure. They are also characterized by the presence of the carotenoid pigment deinoxanthin that give them their pink color. They are usually isolated according to these two criteria. In August 2020, scientists reported that bacteria from Earth, particularly Deinococcus bacteria, were found to survive for three years in outer space, based on studies conducted on the International Space Station. These findings support the notion of panspermia, the hypothesis that life exists throughout the Universe, distributed in various ways, including space dust, meteoroids, asteroids, comets, planetoids or contaminated spacecraft.

Nitrospirota is a phylum of bacteria. It includes multiple genera, such as Nitrospira, the largest. The first member of this phylum, Nitrospira marina, was discovered in 1985. The second member, Nitrospira moscoviensis, was discovered in 1995.

The phylum Elusimicrobiota, previously known as "Termite Group 1", has been shown to be widespread in different ecosystems like marine environment, sewage sludge, contaminated sites and soils, and toxic wastes. The high abundance of Elusimicrobiota representatives is only seen for the lineage of symbionts found in termites and ants.

The Negativicutes are a class of bacteria in the phylum Bacillota, whose members have a peculiar cell wall with a lipopolysaccharide outer membrane which stains gram-negative, unlike most other members of the Bacillota. Although several neighbouring Clostridia species also stain gram-negative, the proteins responsible for the unusual diderm structure of the Negativicutes may have actually been laterally acquired from Pseudomonadota. Additional research is required to confirm the origin of the diderm cell envelope in the Negativicutes.

Acidaminococcus is a genus in the phylum Bacillota (Bacteria), whose members are anaerobic diplococci that can use amino acids as the sole energy source for growth. Like other members of the class Negativicutes, they are gram-negative, despite being Bacillota, which are normally gram-positive.

The Selenomonadales are an order of bacteria within the class Negativicutes; unlike most other members of Bacillota, they are Gram-negative. The phylogeny of this order was initially determined by 16S rRNA comparisons. More recently, molecular markers in the form of conserved signature indels (CSIs) have been found specific for all Selenomonadales species. On the basis of these markers, the Selenomonadales are inclusive of two distinct families, and are no longer the sole order within the Negativicutes. Several CSIs have also been found specific for both families, Sporomusaceae and Selenomonadceae. Samples of bacterial strains within this order have been isolated from the root canals of healthy human teeth.

The Coriobacteriia are a class of Gram-positive bacteria within the Actinomycetota phylum. Species within this group are nonsporulating, strict or facultative anaerobes that are capable of thriving in a diverse set of ecological niches. Gordonibacter species are the only members capable of motility by means of flagella within the class. Several species within the Coriobacteriia class have been implicated with human diseases that range in severity. Atopobium, Olsenella, and Cryptobacterium species have responsible for human oral infections including periodontitis, halitosis, and other endodontic infections. Eggerthella species have been associated with severe blood bacteraemia and ulcerative colitis.

The Eggerthellaceae are a family of Gram-positive, rod- or coccus-shaped Actinomycetota. It is the sole family within the order Eggerthellales.

References

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