Synergistota

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Synergistota
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Jumas-Bilak et al. 2021 [1]
Phylum: Synergistota
Jumas-Bilak et al. 2009
Class: Synergistia
Jumas-Bilak et al. 2009
Order: Synergistales
Jumas-Bilak et al. 2009
Families
  • Acetomicrobiaceae
  • Aminiphilaceae
  • Aminithiophilaceae
  • Aminobacteriaceae
  • Dethiosulfovibrionaceae
  • Synergistaceae
  • Thermosynergistaceae
  • Thermovirgaceae
Synonyms
  • "Synergistaeota" Oren et al. 2015
  • "Synergistetes" Jumas-Bilak et al. 2009
  • "Synergistota" Whitman et al. 2018

The Synergistota is a phylum of anaerobic bacteria that show Gram-negative staining and have rod/vibrioid cell shape. [2] [3] Although Synergistota have a diderm cell envelope, [4] [5] the genes for various proteins involved in lipopolysaccharides biosynthesis have not yet been detected in Synergistota, indicating that they may have an atypical outer cell envelope. [4] [5] The Synergistota inhabit a majority of anaerobic environments including animal gastrointestinal tracts, soil, oil wells, and wastewater treatment plants and they are also present in sites of human diseases such as cysts, abscesses, and areas of periodontal disease. [6] [7] Due to their presence at illness related sites, the Synergistota are suggested to be opportunistic pathogens but they can also be found in healthy individuals in the microbiome of the umbilicus and in normal vaginal flora. [7] [8] Species within this phylum have also been implicated in periodontal disease, [9] gastrointestinal infections and soft tissue infections. [7] Other species from this phylum have been identified as significant contributors in the degradation of sludge for production of biogas in anaerobic digesters and are potential candidates for use in renewable energy production through their production of hydrogen gas. [10] All of the known Synergistota species and genera are presently part of a single class (Synergistia), order (Synergistiales), and family (Synergistaceae). [3]

Contents

Comparative genomics and molecular signatures

Recent comparative analyses of sequenced Synergistota genomes have led to identification of large numbers of conserved signature indels (CSIs) in protein sequences that are specific for either all sequenced Synergistota species or some of their sub-clades that are observed in phylogenetic trees. [11] Of the CSIs that were identified, 32 in widely distributed proteins such as RpoB, RpoC, UvrD, GyrA, PolA, PolC, MraW, NadD, PyrE, RpsA, RpsH, FtsA, RadA, etc., including a large >300 aa insert in the RpoC protein, are present in various Synergistota species, but except for isolated bacteria, these CSIs are not found in the protein homologues from all other organisms. These CSIs provide novel molecular markers for distinguishing Synergistota species from all other bacteria. [11] Seven other CSIs in important proteins including a 13 aa in RpoB were found to be uniquely present in Jonquetella, Pyramidobacter and Dethiosulfovibrio species indicating a close and specific relationship among these bacteria, which is also strongly supported by phylogenetic trees. Fifteen addition CSIs that were only present in Jonquetella and Pyramidobacter indicate a close association between these two species. [11] Lastly, a close relationship between the Aminomonas and Thermanaerovibrio species is also supported by 9 identified CSIs. The identified molecular markers provide reliable means for the division of species from the phylum Synergistota into intermediate taxonomic ranks such as families and orders. [11]

Phylogeny

16S rRNA based LTP_12_2021 [12] [13] [14] 120 single copy marker proteins based GTDB 08-RS214 [15] [16] [17]
Synergistota

Thermosynergistes pyruvativorans

Acetomicrobium

A. flavidum

A. mobile

A. hydrogeniformans

A. thermoterrenum

Thermovirga lienii

Aminiphilus circumscriptus

Aminomonas paucivorans

Thermanaerovibrio

T. acidaminovorans

T. velox

Synergistes jonesii

Cloacibacillus

C. evryensis

C. porcorum

Lactivibrio alcoholicus

Aminivibrio pyruvatiphilus

Fretibacterium fastidiosum

Aminobacterium

A. thunnarium

A. colombiense

A. mobile

Jonquetella anthropi

Rarimicrobium hominis

Pyramidobacter

P. piscolens

P. porci

Dethiosulfovibrio

D. salsuginis

D. peptidovorans

D. marinus

D. acidaminovorans

D. russensis

Synergistota
Thermosynergistaceae

Thermosynergistes pyruvativorans

Acetomicrobiaceae
Acetomicrobium

A. flavidum

A. hydrogeniformans

A. thermoterrenum

Thermovirgaceae

Thermovirga lienii

Aminiphilaceae

Aminiphilus circumscriptus

Synergistaceae

Aminomonas paucivorans

Thermanaerovibrio

T. acidaminovorans

T. velox

"Ca.  Caccocola"

"Ca. C. faecigallinarum"

"Ca. C. faecipullorum"

Synergistes jonesii

Cloacibacillus

C. evryensis

C. porcorum

Aminobacteriaceae

Aminivibrio pyruvatiphilus

Fretibacterium fastidiosum

Aminobacterium

A. colombiense

A. mobile

Dethiosulfovibrionaceae

Jonquetella anthropi

Pyramidobacter

P. piscolens

P. porci

Dethiosulfovibrio

D. salsuginis

D. faecalis

D. peptidovorans

D. russensis

Taxonomy

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LSPN) [18] and the National Center for Biotechnology Information (NCBI). [19]

Related Research Articles

<span class="mw-page-title-main">Spirochaete</span> Phylum of bacteria

A spirochaete or spirochete is a member of the phylum Spirochaetota, which contains distinctive diderm (double-membrane) gram-negative bacteria, most of which have long, helically coiled cells. Spirochaetes are chemoheterotrophic in nature, with lengths between 3 and 500 μm and diameters around 0.09 to at least 3 μm.

<span class="mw-page-title-main">Nanoarchaeota</span> Phylum of archaea

Nanoarchaeota is a proposed phylum in the domain Archaea that currently has only one representative, Nanoarchaeum equitans, which was discovered in a submarine hydrothermal vent and first described in 2002.

<span class="mw-page-title-main">Deinococcota</span> Phylum of Gram-negative bacteria

Deinococcota is a phylum of bacteria with a single class, Deinococci, that are highly resistant to environmental hazards, also known as extremophiles. These bacteria have thick cell walls that give them gram-positive stains, but they include a second membrane and so are closer in structure to those of gram-negative bacteria.

<span class="mw-page-title-main">Verrucomicrobiota</span> Phylum of bacteria

Verrucomicrobiota is a phylum of Gram-negative bacteria that contains only a few described species. The species identified have been isolated from fresh water, marine and soil environments and human faeces. A number of as-yet uncultivated species have been identified in association with eukaryotic hosts including extrusive explosive ectosymbionts of protists and endosymbionts of nematodes residing in their gametes.

<span class="mw-page-title-main">Chlamydiota</span> Phylum of bacteria

The Chlamydiota are a bacterial phylum and class whose members are remarkably diverse, including pathogens of humans and animals, symbionts of ubiquitous protozoa, and marine sediment forms not yet well understood. All of the Chlamydiota that humans have known about for many decades are obligate intracellular bacteria; in 2020 many additional Chlamydiota were discovered in ocean-floor environments, and it is not yet known whether they all have hosts. Historically it was believed that all Chlamydiota had a peptidoglycan-free cell wall, but studies in the 2010s demonstrated a detectable presence of peptidoglycan, as well as other important proteins.

<span class="mw-page-title-main">Acholeplasmataceae</span> Family of bacteria

Acholeplasmataceae is a family of bacteria. It is the only family in the order Acholeplasmatales, placed in the class Mollicutes. The family comprises the genera Acholeplasma and Phytoplasma. Phytoplasma has the candidatus status, because members still could not be cultured.

The Thermotogota are a phylum of the domain Bacteria. The phylum Thermotogota is composed of Gram-negative staining, anaerobic, and mostly thermophilic and hyperthermophilic bacteria.

<span class="mw-page-title-main">Bifidobacteriaceae</span> Family of bacteria

The Bifidobacteriaceae are the only family of bacteria in the order Bifidobacteriales. According to the 16S rRNA-based LTP release 106 published by 'The All-Species Living Tree' Project, the order Bifidobacteriales is a clade nested within the suborder Micrococcineae, also the genus Bifidobacterium is paraphyletic to the other genera within the family, i.e. the other genera are nested within Bifidobacterium.

Fibrobacterota is a small bacterial phylum which includes many of the major rumen bacteria, allowing for the degradation of plant-based cellulose in ruminant animals. Members of this phylum were categorized in other phyla. The genus Fibrobacter was removed from the genus Bacteroides in 1988.

The Gemmatimonadota are a phylum of bacteria established in 2003. The phylum contains two classes Gemmatimonadetes and Longimicrobia.

The Chloroflexota are a phylum of bacteria containing isolates with a diversity of phenotypes, including members that are aerobic thermophiles, which use oxygen and grow well in high temperatures; anoxygenic phototrophs, which use light for photosynthesis ; and anaerobic halorespirers, which uses halogenated organics as electron acceptors.

The Veillonellaceae are a family of the Clostridia, formerly known as Acidaminococcaceae. Bacteria in this family are grouped together mainly based on genetic studies, which place them among the Bacillota. Supporting this placement, several species are capable of forming endospores. However, they differ from most other Bacillota in having Gram-negative stains. The cell wall composition is peculiar.

The phylum Elusimicrobiota, previously known as "Termite Group 1", has been shown to be widespread in different ecosystems like marine environment, sewage sludge, contaminated sites and soils, and toxic wastes. The high abundance of Elusimicrobiota representatives is only seen for the lineage of symbionts found in termites and ants.

The Negativicutes are a class of bacteria in the phylum Bacillota, whose members have a peculiar cell wall with a lipopolysaccharide outer membrane which stains gram-negative, unlike most other members of the Bacillota. Although several neighbouring Clostridia species also stain gram-negative, the proteins responsible for the unusual diderm structure of the Negativicutes may have actually been laterally acquired from Pseudomonadota. Additional research is required to confirm the origin of the diderm cell envelope in the Negativicutes.

Acidaminococcus is a genus in the phylum Bacillota (Bacteria), whose members are anaerobic diplococci that can use amino acids as the sole energy source for growth. Like other members of the class Negativicutes, they are gram-negative, despite being Bacillota, which are normally gram-positive.

The Selenomonadales are an order of bacteria within the class Negativicutes; unlike most other members of Bacillota, they are Gram-negative. The phylogeny of this order was initially determined by 16S rRNA comparisons. More recently, molecular markers in the form of conserved signature indels (CSIs) have been found specific for all Selenomonadales species. On the basis of these markers, the Selenomonadales are inclusive of two distinct families, and are no longer the sole order within the Negativicutes. Several CSIs have also been found specific for both families, Sporomusaceae and Selenomonadceae. Samples of bacterial strains within this order have been isolated from the root canals of healthy human teeth.

The Coriobacteriia are a class of Gram-positive bacteria within the Actinomycetota phylum. Species within this group are nonsporulating, strict or facultative anaerobes that are capable of thriving in a diverse set of ecological niches. Gordonibacter species are the only members capable of motility by means of flagella within the class. Several species within the Coriobacteriia class have been implicated with human diseases that range in severity. Atopobium, Olsenella, and Cryptobacterium species have responsible for human oral infections including periodontitis, halitosis, and other endodontic infections. Eggerthella species have been associated with severe blood bacteraemia and ulcerative colitis.

Negativicoccus succinicivorans is a Gram-negative and anaerobic bacterium from the genus of Negativicoccus which has been isolated from a human toe wound in France.

<span class="mw-page-title-main">Atribacterota</span> Phylum of bacteria

Atribacterota is a phylum of bacteria, which are common in anoxic sediments rich in methane. They are distributed worldwide and in some cases abundant in anaerobic marine sediments, geothermal springs, and oil deposits. Genetic analyzes suggest a heterotrophic metabolism that gives rise to fermentation products such as acetate, ethanol, and CO2. These products in turn can support methanogens within the sediment microbial community and explain the frequent occurrence of Atribacterota in methane-rich anoxic sediments. According to phylogenetic analysis, Atribacterota appears to be related to several thermophilic phyla within Terrabacteria or may be in the base of Gracilicutes. According to research, Atribacterota shows patterns of gene expressions which consists of fermentative, acetogenic metabolism. These expressions let Atribacterota to be able to create catabolic and anabolic functions which are necessary to generate cellular reproduction, even when the energy levels are limited due to the depletion of dissolved oxygen in the areas of sea waters, fresh waters, or ground waters.

Jonquetella is a Gram-negative and strictly aerobic genus of bacteria from the family of Synergistaceae with one known species. Jonquetella anthropi has been isolated from a human cyst from Montpellier in France.

References

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