Aminomuconate-semialdehyde dehydrogenase

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aminomuconate-semialdehyde dehydrogenase
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aminomuconate-semialdehyde dehydrogenase tetramer, Pseudomonas
Identifiers
EC no. 1.2.1.32
CAS no. 37250-95-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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In enzymology, aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
H2O
H+
Aminomuconate-semialdehyde dehydrogenase
H2O
H+
 
+ NADH
 

The three substrates of this enzyme are 2-aminomuconic semialdehyde, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are 2-aminomuconic acid, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in 3 metabolic pathways: benzoic acid degradation via hydroxylation, tryptophan metabolism, and the degradation pathway for toluene and xylene.

Nomenclature

The systematic name of this enzyme class is 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase. Other names in common use include 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, and 2-hydroxymuconic semialdehyde dehydrogenase.

References

  1. Enzyme 1.2.1.32 at KEGG Pathway Database.
  2. Ichiyama A, Nakamura S, Kawai H, Honjo T, Nishizuka Y, Hayaishi O, Senoh S (February 1965). "Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid". The Journal of Biological Chemistry. 240 (2): 740–9. doi: 10.1016/S0021-9258(17)45238-0 . PMID   14275130.