Atopobium

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Atopobium
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Bacillati
Phylum: Actinomycetota
Class: Coriobacteriia
Order: Coriobacteriales
Family: Atopobiaceae
Genus: Atopobium
Collins and Wallbanks 1993 [1]
Type species
Atopobium minutum
(Hauduroy et al. 1937) Collins & Wallbanks 1993
Species [2]
  • A. deltae
  • "A. detroiti"
  • A. fossor
  • "A. massiliense"
  • A. minutum

Atopobium is a genus of Actinomycetota, in the family Coriobacteriaceae. Atopobium species are anaerobic, Gram-positive rod-shaped or elliptical bacteria found as single elements or in pairs or short chains.

Contents

Atopobium vaginae was discovered in 1999. [3] This is a facultative anaerobic bacteria, which form small colonies on blood agar at 37 °C is also positive for acid phosphatase. This species has now been reclassified into the genus Fannyhessea following phylogenetic studies.

Clinical significance

The genus Atopobium may be associated with bacterial vaginosis. [4] [5] [6]

The genus may play a role in the development of Colorectal cancer. While the genus has been reported as overrepresented in feces of patients, [7] A. minutum has conversely shown a mild apoptotic effect on cancer cells in vitro and has been suggested to be comparable to probiotic bacteria in regards to colorectal cancer. [8]


Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) [1] and National Center for Biotechnology Information (NCBI). [2]

16S rRNA based LTP_10_2024 [9] [10] [11] 120 marker proteins based GTDB 09-RS220 [12] [13] [14]
Atopobium

A. deltaeCools et al. 2014

A. fossor(Bailey and Love 1986) Kageyama et al. 1999

A. minutum(Hauduroy et al. 1937) Collins and Wallbanks 1993

Atopobium

A. deltae

A. fossor

A. minutum

See also

References

  1. 1 2 A.C. Parte; et al. "Atopobium". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2025-02-28.
  2. 1 2 C.L. Schoch; et al. "Atopobium". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2025-02-28.
  3. ↑ Rodriguez Jovita M, Collins MD, Sjödén B, Falsen E (1999). "Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae sp. nov". Int J Syst Bacteriol. 49 (4): 1573–6. doi: 10.1099/00207713-49-4-1573 . PMID   10555338.
  4. ↑ Verhelst R, Verstraelen H, Claeys G, Verschraegen G, Delanghe J, Van Simaey L, De Ganck C, Temmerman M, Vaneechoutte M (Apr 21, 2004). "Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis". BMC Microbiol. 4 (16): 1573–6. doi: 10.1186/1471-2180-4-16 . PMC   419343 . PMID   15102329.
  5. ↑ Burton JP, Devillard E, Cadieux PA, Hammond JA, Reid G (Apr 21, 2004). "Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation". J Clin Microbiol. 42 (16): 1829–1831. doi:10.1128/jcm.42.4.1829-1831.2004. PMC   387601 . PMID   15071062.
  6. ↑ Burton JP, Chilcott CN, Al-Qumber M, Brooks HJ, Wilson D, Tagg JR, Devenish C (October 2005). "A preliminary survey of Atopobium vaginae in women attending the Dunedin gynaecology out-patients clinic: is the contribution of the hard-to-culturemicrobiota overlooked in gynaecological disorders?". The Australian and New Zealand Journal of Obstetrics and Gynaecology. 45 (5): 450–2. doi:10.1111/j.1479-828X.2005.00456.x. PMID   16171487. S2CID   44888920.
  7. ↑ Ahn, J.; Sinha, R.; Pei, Z.; Dominianni, C.; Wu, J.; Shi, J.; Goedert, J. J.; Hayes, R. B.; Yang, L. (18 December 2013). "Human Gut Microbiome and Risk for Colorectal Cancer". J Natl Cancer Inst. 105 (24): 1907–1911. doi:10.1093/jnci/djt300. PMC   3866154 . PMID   24316595.
  8. ↑ Altonsy, M.O.; Andrews, S.C.; Tuohy, K.M. (28 February 2010). "Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enterophathogenic bacteria: mediation by the mitochondrial pathway". International Journal of Food Microbiology. 137 (2–3): 190–203. doi:10.1016/j.ijfoodmicro.2009.11.015. PMID   20036023.
  9. ↑ "The LTP" . Retrieved 10 December 2024.
  10. ↑ "LTP_all tree in newick format" . Retrieved 10 December 2024.
  11. ↑ "LTP_10_2024 Release Notes" (PDF). Retrieved 10 December 2024.
  12. ↑ "GTDB release 09-RS220". Genome Taxonomy Database . Retrieved 10 May 2024.
  13. ↑ "bac120_r220.sp_labels". Genome Taxonomy Database . Retrieved 10 May 2024.
  14. ↑ "Taxon History". Genome Taxonomy Database . Retrieved 10 May 2024.
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