Name North or east end South or west end U.S. Highways (approximate, based on 1926 plan and later additions) Notes Albert Pike Highway Hot Springs, Arkansas Colorado Springs, Colorado US 270 , US 64 , US 183 , US 154 , US 50 , US 85 Aroostook Trail Old Town, Maine Fairfield, Maine Maine Route 100 , US 2 Arrowhead Trail Salt Lake City, Utah Los Angeles, California US 91 Atlantic Highway Calais, Maine Miami, Florida US 1 , US 25 , US 17 , US 1 Atlantic-Pacific Highway New York, New York Los Angeles, California US 1 , US 211 , US 15 , US 33 , US 60 , US 52 , US 460 , US 50 , US 54 , US 70 , US 60 Atlantic Yellowstone Pacific Highway Chicago, Illinois Sioux Falls, South Dakota US 20 , US 218 , US 18 Baltimore Pike Philadelphia, Pennsylvania Baltimore, Maryland Bankhead Highway Washington, D.C. San Diego, California US 1 , US 15 , US 70 , US 170 , US 29 , US 78 , US 70, US 67 , US 80 Bee Line Highway Chicago, Illinois New Orleans, Louisiana US 51 Ben Hur Highway St. Louis, Missouri Fort Dodge, Iowa Black and Yellow Trail Chicago, Illinois Yellowstone National Park US 41 , US 16 , US 14 , US 16, US 20 Blackhawk Highway Dixon, Illinois Beloit, Wisconsin IL 2 , IL 251 , US 51 Broadway Of America New York City, New York San Diego, California US 80 , Arizona 87 , Arizona 84 , US 80, US 67 , US 70 , US 41 , US 70S , US 70, US 11W , US 11 , US 211 , US 1 , US 40 , US 13 , US 1 Later addition auto trail, established in 1930. One alignment used Arizona 87 and Arizona 84 between Gila Bend and Tucson, another followed US 80 between both cities. [ 1] [ 2] California-Banff Bee Line Cannon Ball Route Chicago, Illinois Hannibal, Missouri Capital Route Omaha, Nebraska Austin, Texas Chicago, Kansas City and Gulf Highway Chicago, Illinois Galveston, Texas Colorado to Gulf Highway Denver, Colorado Galveston, Texas , and Brownsville, Texas US 85 , US 385 , US 370 , US 81 , US 181 Columbia River Highway Pendleton, Oregon Portland, Oregon US 30 Cooley Highway Grand Rapids, Minnesota Sisseton, South Dakota Cornhusker Highway Sioux City, Iowa Oklahoma City, Oklahoma Custer Battlefield Highway Omaha, Nebraska Glacier National Park US 75 , US 16 , US 116 , US 87E , US 87 Dallas-Canadian-Denver Highway Boulder, Colorado Galveston, Texas US 85 , US 50 , US 83 , US 70 , US 77 Daniel Webster Highway Chartierville, Quebec Franconia, New Hampshire Detroit-Lincoln-Denver Highway Detroit , Michigan Denver, Colorado US 12 , US 32 , US 38 Dixie Highway Chicago, Illinois and Sault Ste. Marie, Michigan Miami, Florida Illinois 1 , US 136 , US 31 , Indiana 37 , US 150 , US 31W Dixie Bee Line Chicago, Illinois Nashville, Tennessee US 41 , US 241 Dixie Overland Highway Savannah, Georgia San Diego, California US 80 , US 84 , US 380 , US 366 , US 80 Egyptian Trail Chicago, Illinois Cairo, Illinois Electric Highway (Auto trail) Forsyth, Montana Helena, Montana US 12 , US 89 Evergreen National Highway Victoria, British Columbia El Paso, Texas US 99 , US 10 , US 97 , US 410 , US 95 , US 30 , US 30N , US 91 , US 95, US 66 Florida Short Route French Lick Route Cincinnati, Ohio Evansville, Indiana US 50 , State Road 37 , US 150 , State Road 56 , US 231 , and State Road 62 George Washington Memorial Highway Cambridge, Massachusetts Agawam, Massachusetts George Washington National Highway Savannah, Georgia Seattle, Washington Geysers-to-Glaciers Highway Glacier National Park Yellowstone National Park US 89 W from West Yellowstone to Shelby, Montana ; US 2 from Shelby to Cut Bank, Montana ; and MT 213 from Cut Bank to the Canada–US border [ 3] [ 4] Glacier to Gulf Motorway Calgary , Alberta Tampico, Mexico Glacier Trail Seattle, Washington Jacksonville, Florida Grant Highway Chicago, Illinois Portland, Oregon US 20 Great Plains Road Portal, North Dakota Brownsville, Texas Great White Way Davenport, Iowa Council Bluffs, Iowa US 6 Also known as the White Pole Road International Peace Highway Quebec, Quebec , and Rouses Point, New York Laredo, Texas , and Mexico City , Mexico Jackson Highway Chicago, Illinois New Orleans, Louisiana US 152 , US 52 , US 31 , US 168 , US 68 , US 31, US 43 , US 45 , US 11 Jefferson Highway Winnipeg , Manitoba New Orleans, Louisiana US 59 , US 2 , US 71 , US 10N , US 10 , US 65 , US 69 , US 71 /US 73E , US 73 , US 75 , US 69 , US 67 , US 271 , US 80 , US 171 , US 71, US 61 Jefferson Davis National Highway Washington, D.C. San Diego, California US 1 , US 278 , US 29 , US 80 , US 43 , US 90 , US 96 , US 277 , US 90 King of Trails Winnipeg , Manitoba Galveston, Texas , and Brownsville, Texas US 75 /US 81 , US 75/US 77 , US 75, US 73 , US 73E , US 50 , US 73W , US 75, US 77, US 81 , US 181 , US 96 Lackawanna Trail Binghamton, New York Delaware, New Jersey US 11 , [ 5] [ unreliable source? ] US 611 [ 6] [ unreliable source? ] Lakes to Gulf Highway Duluth, Minnesota Galveston, Texas Lakes-to-Sea Highway Atlantic City, New Jersey Erie, Pennsylvania US 30 , US 120 , US 22 , US 322 , US 19 Lee Highway Washington DC San Diego, California US 1 , US 211 , US 11 , US 72 , US 70 , US 366 , US 80 , US 180 , US 80, US 101 Lewis and Clark Highway Missoula, Montana Lewiston, Idaho Liberty Highway New York, New York Cleveland, Ohio New Jersey 4 , New Jersey 17 , New York 17 , New York 430 , New York 394 , US 20 [ 7] Lincoln Highway New York, New York San Francisco, California US 1 , US 30 , US 40 , US 93 , US 50 , US 99 , US 48 Logan-Lee Highway Rock Island, Illinois Paducah, Kentucky US 67 , Illinois 3 Lone Star Route Chicago, Illinois Lake Charles, Louisiana (earlier Brownsville, Texas ) US 66 , US 67 , US 63 , US 165 Lone Star Trail St. Augustine, Florida Los Angeles, California US 1 , US 90 , US 84 , US 67 , US 290 , US 80 , Arizona 86 , US 80, Arizona 84 , Maricopa–Casa Grande Highway (Arizona), Gila Bend–Maricopa Highway (Arizona) , US 80 Magnolia Route Meridian Highway Winnipeg , Manitoba Mexico City , Mexico US 81 Mississippi River Scenic Highway Winnipeg , Manitoba , and Port Arthur, Ontario Fort Myers, Florida and Port Arthur, Texas US 75 , US 2 , US 71 , US 10N , US 10 , US 61 , US 55 , US 61, US 90 ; US 49E , US 49 , US 98 , US 90 , US 19 , US 41 Mississippi Valley Highway Ely, Minnesota Gulfport, Mississippi (earlier New Orleans, Louisiana ) US 53 , US 61 , US 55 , US 161 , US 67 , US 51 , US 45 , US 11 , US 49 Earlier known as the Burlington Way National Old Trails Road Washington, D.C. , and Baltimore, Maryland Los Angeles, California US 240 /US 40 , US 40, US 50N , US 50 , US 350 , US 85 , US 70 , US 66 National Park-to-Park Highway Loop connecting National Parks US 99 , US 48 , US 40 , US 99E , US 99, US 10 , US 195 , US 95 , US 2 , US 87 , US 87W , US 20 , US 185 , US 85 , US 50 , US 285 , US 450 , US 550 , US 64 , US 666 , US 66 National Parks Highway Boston, Massachusetts , and New York, New York Seattle, Washington Also known as the Northwest Trail National Roosevelt Midland Trail Washington, D.C. and Newport News, Virginia (earlier Oyster Bay, New York ) Los Angeles, California US 60 , US 150 , US 50 , US 40 , US 40N , US 40, US 40S , US 50, US 6 New Santa Fe Trail Kansas City, Mo. Los Angeles US 50 , US 350 , US 85 , US 66 Old Oregon Trail Independence, Missouri Seaside, Oregon , and Olympia, Washington US 40 , US 30 , US 26 , US 20 , US 87E , US 30N , US 30 Old Spanish Trail St. Augustine, Florida San Diego, California US 1 , US 90 , US 80 Ozark Trails Kansas City, Missouri , Hannibal, Missouri , St. Louis, Missouri , and Memphis, Tennessee Denver, Colorado , Las Vegas, New Mexico , and El Paso, Texas Pacific Highway Vancouver , British Columbia San Diego, California US 99 , US 40 , US 101 Pershing Way Winnipeg , Manitoba New Orleans, Louisiana Pikes Peak Ocean to Ocean Highway New York, New York Los Angeles, California (earlier San Francisco, California ) US 22 , US 250 , US 36 , US 136 , US 36, US 40N , US 40S , US 50 , US 91 Also known as the Pershing Transport Route Puget Sound-to-Gulf Highway Red Ball Route River-to-River Road Davenport, Iowa Council Bluffs, Iowa Southern National Highway Southwest Trail Chicago, Illinois El Paso, Texas US 32 , US 65 , US 50S , US 81 , US 160 , US 281 , US 60 , US 366 Susquehanna Trail Buffalo, New York Washington, D.C. US 20 , US 15 , US 111 /US 240 Theodore Roosevelt International Highway Portland, Maine Portland, Oregon US 302 , US 2 , US 11 , US 104 , US 23 , US 2, US 95 , US 195 , US 295 , US 410 , US 30 Three C Highway Cleveland, Ohio Cincinnati, Ohio Ohio SR 3 Transprovincial Highway Ottawa Toronto Later Ontario Highway 2 and Ontario Highway 15 Victory Highway New York, New York San Francisco, California US 1 , US 40 , US 40S , US 83 , US 40N , US 40 White River Trail Springfield, Missouri Ponca City, Oklahoma White-way 7 Highway Chicago, Illinois Omaha, Nebraska US 32 In Iowa, created from segments of the River to River Road from Davenport to Redfield, and the Great White Way from Dexter to Council Bluffs. William Penn Highway New York, New York Pittsburgh, Pennsylvania US 22 Yellowstone Highway Denver, Colorado Yellowstone National Park Yellowstone Trail Plymouth, Massachusetts Seattle, Washington US 20 , US 30 , US 41 , US 110 , US 10 , US 212 , US 12 , US 10, US 195 , US 295 , US 410 , US 97 , US 10