B-1,3-galactosyl-O-glycosyl-glycoprotein b-1,6-N-acetylglucosaminyltransferase

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Identifiers
EC no.	2.4.1.102
CAS no.	95978-15-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, beta6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase, core 2 acetylglucosaminyltransferase, core 6-beta-GlcNAc-transferase A, UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R ${\displaystyle \rightleftharpoons }$ UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R

References

1. Brockhausen I, Rachaman ES, Matta KL, Schachter H (August 1983). "The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis". Carbohydrate Research. 120: 3–16. doi:10.1016/0008-6215(83)88002-1. PMID   6226356.
2. Williams D, Longmore G, Matta KL, Schachter H (December 1980). "Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 255 (23): 11253–61. PMID   6449508.
3. Williams D, Schachter H (December 1980). "Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates". The Journal of Biological Chemistry. 255 (23): 11247–52. PMID   6449507.

External links

• Beta-1,3-galactosyl-O-glycosyl-glycoprotein+beta-1,6-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)