Cloperidone

Last updated

Cloperidone
Cloperidone.svg
Identifiers
  • 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C21H23ClN4O2
Molar mass 398.89 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CCCN2C(=O)C3=CC=CC=C3NC2=O)C4=CC(=CC=C4)Cl
  • InChI=1S/C21H23ClN4O2/c22-16-5-3-6-17(15-16)25-13-11-24(12-14-25)9-4-10-26-20(27)18-7-1-2-8-19(18)23-21(26)28/h1-3,5-8,15H,4,9-14H2,(H,23,28)
  • Key:FXZJKVODWNYPKK-UHFFFAOYSA-N

Cloperidone is a quinazolinedione derivative first reported in 1965 by Miles Laboratories, notable for its sedative and antihypertensive properties. [1] [2] Its pharmacological activity has been demonstrated in various animal models, including behavioral studies in dogs and cats, as well as motor coordination and locomotor activity assays in mice. [2] Cloperidone is not an approved drug and appears to remain an experimental compound with no current clinical use. [2]

References

  1. ↑ Hayao S, Havera HJ, Strycker WG, Leipzig TJ, Kulp RA, Hartzler HE (November 1965). "New sedative and hypotensive 3-substituted 2,4(1H,3H)-quinazolinediones". Journal of Medicinal Chemistry. 8 (6): 807–815. doi:10.1021/jm00330a017. PMID   5885076.
  2. 1 2 3 "Cloperidone hydrochloride". Inxight Drugs. NCATS. Retrieved 8 June 2025.
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