Glucosyl-3-phosphoglycerate synthase

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Glucosyl-3-phosphoglycerate synthase
Identifiers
EC no. 2.4.1.266
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Glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266, GpgS protein, GPG synthase, glucosylphosphoglycerate synthase) is an enzyme with systematic name NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase. [1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

NDP-glucose + 3-phospho-D-glycerate NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate.

References

  1. ↑ Costa J, Empadinhas N, da Costa MS (March 2007). "Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina". Journal of Bacteriology. 189 (5): 1648–54. doi:10.1128/JB.00841-06. PMC   1855766 . PMID   17189358.
  2. ↑ Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS (February 2006). "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology. 188 (3): 1022–30. doi:10.1128/JB.188.3.1022-1030.2006. PMC   1347341 . PMID   16428406.
  3. ↑ Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS (March 2008). "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". FEMS Microbiology Letters. 280 (2): 195–202. doi: 10.1111/j.1574-6968.2007.01064.x . PMID   18221489.
  4. ↑ Pereira PJ, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S (2008). Song H (ed.). "Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis". PLOS ONE. 3 (11) e3748. Bibcode:2008PLoSO...3.3748P. doi: 10.1371/journal.pone.0003748 . PMC   2581804 . PMID   19015727.
  5. ↑ Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME (December 2008). "Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis". Acta Crystallographica Section F. 64 (Pt 12): 1121–4. doi:10.1107/S1744309108032892. PMC   2593697 . PMID   19052364.
  6. ↑ Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M (2009). Herman C (ed.). "Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria". PLOS ONE. 4 (5) e5447. Bibcode:2009PLoSO...4.5447K. doi: 10.1371/journal.pone.0005447 . PMC   2674218 . PMID   19421329.
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